Puerto Santa Ana Vacations from $277
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Photo by Paula Vernimmen
Your Puerto Santa Ana Vacation
With plenty of highlights as well as some hidden gems, this city is best experienced with a Puerto Santa Ana vacation package. Find somewhere to stay in Downtown Guayaquil, which is good for views, culture and history. Malecon 2000, Banco Pichincha Monumental Stadium and Mall del Sol Commercial Center are just a few of the many attractions you'll want to see during your trip to Puerto Santa Ana. Whoever you're taking time off with and whatever you plan to spend, your ultimate Puerto Santa Ana vacation is just a few clicks away with Expedia.
The Latest Puerto Santa Ana Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Mantahost Hotel
Barbasquillo
Price was $371, price is now $277 per person
$277
per person
Nov 30 - Dec 3
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
8.6/10 Excellent! (290 reviews)
Reception in the check in they charge xtra for the IVA taxes that Expedia didn’t include in the price receive. The security box has broken , and every day I have to call the maintenance to open. Extend one day in the reservation makes doble of the initial price very sad.
Reviewed on Oct 18, 2025
Hotel Río Guayas by Art Hotels Ecuador
Las Peñas
Price was $1,788, price is now $1,222 per person
$1,222
per person
Dec 19 - Dec 22
found 18 hours ago
Roundtrip non-stop flight included
New York (NYC) to Guayaquil (GYE)
10/10 Exceptional! (1 review)
The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work.
Reviewed on Oct 25, 2025
Hacienda La Danesa
Save 100% on your flight
Price was $2,324, price is now $1,627 per person
$1,627
per person
Jan 2 - Jan 7
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.6/10 Exceptional! (9 reviews)
The rooms and the views were outstanding. The service and the food were excellent
Reviewed on May 2, 2022
Where to stay in Puerto Santa Ana
Find the best Puerto Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Puerto Santa Ana
Downtown Guayaquil
Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Central Market and Sports Federation of Guayas while you're in town.
Puerto Santa Ana Hotel Deals
Wyndham Guayaquil Puerto Santa Ana
Calle Numa Pompilio Llona S N, Ciudad del Rio - Puerto Santa Ana, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$110 nightly
The price is $123 total per night from Nov 9 to Nov 10
$123 total
Nov 9 - Nov 10
9.2/10 Wonderful! (1,014 reviews)
All good
Reviewed on Oct 20, 2025
River View suites Puerto Santa Ana gye
Puerto Santa Ana, Edificios Riverfront, Bellini, junto al hotel Wyndham., Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$80 nightly
The price is $81 total per night from Oct 30 to Oct 31
$81 total
Oct 30 - Oct 31
8.4/10 Very Good! (39 reviews)
Owners condition that you turn the AC off when you leave and only have the auto fan on left the apartment hot all the time. The location has plenty of restaurant options and the view is nice, especially at night but it does get a little noisy on the riverfront.
Reviewed on Oct 19, 2025
Luxury Suites Riverfront GYE
Puerto Santa Ana, Guayaquil, Guayas
$87 nightly
The price is $88 total per night from Oct 30 to Oct 31
$88 total
Oct 30 - Oct 31
9.4/10 Exceptional! (98 reviews)
Everything, it was incredible. I went with my family and they had a great time.
Reviewed on Oct 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Puerto Santa Ana
Malecon 2000
Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.
Santa Ana Hill
Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.
U.S. Consulate General
U.S. Consulate General is just one of the places to see in San Eduardo, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.
Things to do
Wine Tasting Experience with Tasting Menu
$65
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Hotels near Santa Ana Hill
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- Hotels near Roberto Gilbert Hospital
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- Hotels near Downtown Guayaquil
- Hotels near Malecon 2000
- Hotels near La Rotonda
- Hotels near Centennial Park
- Hotels near Seminario Park
- Hotels near Guayaquil Metropolitan Cathedral
- Hotels near Municipal Museum of Guayaquil
- Hotels near Sports Federation of Guayas
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- Hotels with Restaurants in Kennedy
- Hotels with Room Service in Kennedy
- 5 Star Hotels in Kennedy
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- Hotels near Guayaquil Convention Center
- Hotels near Malecon del Salado
- Hotels near Hospital Clinic Kennedy
- Hotels near Policentro
- Hotels near San Marino Mall
- Hotels near Enrique Sotomayor Maternity Hospital
- Hotels near La Puntilla
- Hotels near Simón Bolívar
- Hotels near World Trade Center
- Hotels near Plaza del Sol
- Hotels near Malecon Mall
- Hotels near Santiago de Guayaquil Catholic University
- Hotels near Jose Joaquin de Olmedo Intl.
- Flights from New York (JFK) to Guayaquil (GYE)
- Flights from Jose Joaquin de Olmedo Intl.
- Flights from Miami (MIA) to Guayaquil (GYE)
- Flights from Los Angeles (LAX) to Guayaquil (GYE)
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- Las Peñas Vacations
- Visit Las Peñas
- El Carmen Hill
- Artisan Market
- La Perla
- Museum of Anthropology and Contemporary Art
- Downtown Guayaquil Vacations
- La Rotonda
- Church of San Francisco
- Visit Downtown Guayaquil
- Centennial Park
- Clock Tower
- Municipal Palace
- Seminario Park
- Simon Bolivar Statue
- Guayaquil Metropolitan Cathedral
- Moorish Clock Tower
- Municipal Museum of Guayaquil
- Sports Federation of Guayas
- Central Market
- Guayaquil Convention Center
- Malecon del Salado
- Visit Kennedy
- Hospital Clinic Kennedy
- Policentro
- San Marino Mall
- Simón Bolívar Vacations
- World Trade Center
- Antonio Neumane Park
- Plaza del Sol
- Mercado Sur
- Santiago de Guayaquil Catholic University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.