Medical Center Vacations from $249

Book a Hotel + Flight or Car together to unlock savings

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

The Latest Medical Center Vacation Packages

Price found within the past 48 hours. Click for updated prices.

American Inn and Suites Dundee

Save 100% on your flight

$249

per person

Sep 17 - Sep 21

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Detroit (DTW)

6.8/10 (1,005 reviews)

$10 fee for pet, rug in hallway was dirty breakfast was very minimal

Reviewed on Aug 16, 2026

Saint John's Resort

Save 100% on your flight

$472

per person

Sep 16 - Sep 19

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Detroit (DTW)

9.6/10 Exceptional! (1,005 reviews)

Beautiful property. The artwork,the chapel, the wine grotto, the waterfall all elevate the property to another level. We stayed for a week and most restaurants were closed except the steakhouse.

Reviewed on Aug 17, 2026

Weber's Hotel & Restaurant

Lakewood

Save 100% on your flight

$611

per person

Oct 14 - Oct 17

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Detroit (DTW)

9.4/10 Exceptional! (1,563 reviews)

The Townsend Hotel

Save 100% on your flight

$586

per person

Sep 16 - Sep 19

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Detroit (DTW)

9.2/10 Wonderful! (780 reviews)

They moved me to another room due to street noise.

Reviewed on Aug 16, 2026

Graduate by Hilton Ann Arbor

Kerrytown

Save 100% on your flight

$744

per person

Oct 8 - Oct 12

found 7 hours ago

Roundtrip flight included

Dallas (DFW) to Detroit (DTW)

9/10 Wonderful! (1,006 reviews)

Where to stay in Medical Center

Find the best Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center

A city skyline at dusk with reflections on the water.

Downtown Detroit

6 out of top 10 points of interest in this area

Central business district meets residential area, Downtown Detroit boasts historic architecture, skyscrapers, and parks. Explore attractions like Campus Martius Park, Fox Theatre, and Detroit Riverwalk, with convenient transport options nearby.

A directional sign with arrows pointing to Paint Creek Trail and Clinton River Trail.

Rochester Hills

Live music, restaurants, and shopping are just a few things travelers enjoy about Rochester Hills. Check out The Village Of Rochester Hills or Meadow Brook Amphitheatre while you're exploring the area.

A cityscape with tall buildings, a statue, and autumn trees.

Midtown

1 out of top 10 points of interest in this area

Historic districts and cultural attractions abound in this area, with highlights like the Detroit Institute of Arts and the Charles H. Wright Museum of African American History. Independent retail outlets are on the rise, especially along the Cass Corridor.

A tall, historic building with many windows and a classical architectural style.

Corktown

Discover Detroit's oldest neighborhood, featuring historic Federal-style homes and charming Irish businesses. Enjoy a stay at the Trumbull & Porter boutique hotel or explore the walkable Mobility Innovation District around Michigan Central Station.

A church with a tall spire and arched windows.

Brush Park

Brush Park might not have many top sights, but Comerica Park and Little Caesars Arena are two attractions nearby that you can check out.

Medical Center Hotel Deals

Hollywood Casino at Greektown

1200 Saint Antoine St Detroit MI

Fully refundableReserve now, pay when you stay

$185 nightly

$215 total

Aug 23 - Aug 24

Total with taxes and fees

8.6/10 Excellent! (5,559 reviews)

"I paid for the luxury suite in full two weeks prior to my stay. When I arrive and attempted to check in, I was informed that the room was unavailable. My information was recorded to receive a refund that I am still awaiting."

Reviewed on Aug 17, 2026

Trumbull and Porter Hotel

1331 Trumbull St Detroit MI

Fully refundableReserve now, pay when you stay

$117 nightly

$132 total

Aug 31 - Sep 1

Total with taxes and fees

MotorCity Casino Hotel

2901 Grand River Ave Detroit MI

Fully refundableReserve now, pay when you stay

$209 nightly

$242 total

Aug 18 - Aug 19

Total with taxes and fees

8.8/10 Excellent! (4,752 reviews)

"I stayed there for my bridal suite for the weekend. The staff was amazing! Everything was great!"

Reviewed on Aug 16, 2026

See all 1,816 properties in Medical Center

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.