Find hotels in Myrtle, MS from $75

The best time to visit Myrtle, Mississippi, is during the spring (April to May) and fall (September to October) when the weather is most pleasant.During these months, you'll find comfortable temperatures, typically ranging from the 60s to high 70s Fahrenheit, making it ideal for exploring the natural beauty of the area. Spring brings blooming wildflowers and lush greenery, while fall offers colorful foliage, particularly around the Holly Springs National Forest, which is just a short drive away. These seasons avoid the high humidity and heat of summer and the cooler, sometimes wet, days of winter.For those interested in outdoor activities like hiking or birdwatching, spring and fall provide the most agreeable conditions. The milder weather makes a stroll through the downtown area, with its historic buildings and local shops, quite enjoyable.

With Expedia, you earn OneKeyCash™* on eligible Myrtle hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.