Top 10 Hotels in Old Appleton, MO (from $67) 2026 - Competitive Prices

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Our top choices for Old Appleton hotels

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A hotel room with two beds, a brick wall, and a wooden headboard.

1. Drury Inn & Suites Jackson MO

Jackson

Thomas

$81 nightly

$86 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

2. Super 8 by Wyndham Perryville

Perryville

paulette

$70 nightly

$80 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A hotel lobby with a seating area, a reception desk, and a bar.

A swimming pool with a diving board, pool rules signs, and lounge chairs.

A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

3. Holiday Inn Express & Suites Perryville by IHG

Perryville

David

$95 nightly

$109 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A hotel room with two beds, a nightstand, a lamp, and a chair.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

4. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

Elaine

$81 nightly

$87 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A reception area with a blue couch, a wooden table with a vase of flowers, and a reception desk with a digital screen.

5. Days Inn by Wyndham Perryville

Perryville

"When renting a motel room under 100 bucks you have to remember, you’re not at the Hilton. This is an aging building although it has been kept up, the bed was comfortable. I slept well. The shower was fantastic and plenty of hot water super easy access and parking . The continental breakfast was better than expected. Air conditioning. Heat worked fine and the place was really quiet. They probably could do a little better job with the coffee, just my opinion."

Jeffrey

$68 nightly

$77 total

Oct 4 - Oct 5

Total with taxes and fees

A modern retail area with a display of local items and snacks.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

6. Tru By Hilton Cape Girardeau

Cape Girardeau

Shannon

$89 nightly

$102 total

Oct 8 - Oct 9

Total with taxes and fees

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

A hotel room with a desk, a television, a coffee maker, a chair, and a window with curtains.

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

7. Quality Inn Perryville I-55

Perryville

Evelynmaryeka

$64 nightly

$73 total

Oct 22 - Oct 23

Total with taxes and fees

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

8. Comfort Suites Jackson-Cape Girardeau

Jackson

VICTORIA

$76 nightly

$82 total

Oct 25 - Oct 26

Total with taxes and fees

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

9. Quality Inn Cape Girardeau North

Cape Girardeau

Danny

$59 nightly

$67 total

Nov 1 - Nov 2

Total with taxes and fees

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A building with a sign that reads "The Atrium Boutique Hotel".

10. The Atrium - A Boutique Hotel

Perryville

Brian

$158 nightly

$181 total

Oct 2 - Oct 3

Total with taxes and fees

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

11. Perryville RV Resort

Perryville

Kevin

$74 nightly

$84 total

Oct 6 - Oct 7

Total with taxes and fees

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.

A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

12. Town House Inn

Jackson

Taylor

$66 nightly

$71 total

Oct 5 - Oct 6

Total with taxes and fees

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

13. Urban Lofts

Perryville

Grace

$295 nightly

$338 total

Oct 3 - Oct 4

Total with taxes and fees

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A room with a white door, a radiator, a blue carpet, and a mural on the wall.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

A kitchen with a large black sink, a window with a view of trees, and a microwave on the counter.

14. The Mediterranean House 1858

Perryville

$713 nightly

$817 total

Oct 6 - Oct 7

Total with taxes and fees

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Top Old Appleton Hotel Reviews

Drury Inn & Suites Jackson MO

10/10 Excellent

"One of the best hotels I have stayed in."

Quality Inn Cape Girardeau North

10/10 Excellent

"Great place great breakfast great room staff was great"

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Clean rooms. Nice breakfast. Very nice staff."

Super 8 by Wyndham Perryville

10/10 Excellent

"The staff is accommodating and room clean… perfect for my stay rolling through the area."

Days Inn by Wyndham Perryville

8/10 Good

Holiday Inn Express & Suites Perryville by IHG

10/10 Excellent

"Check in and check out for 25 rooms was a breeze. Hotel room cards were ready as soon as we approached the hotel counter."

Hot Tub & Creek Views: Secluded Perryville Cabin

10/10 Excellent

"Wonderful location with the necessities to enjoy your time without taking away from the beauty of where you are"

The Twisted Sassafras Treehouse

10/10 Excellent

"One of the best getaways anyone could possibly find.Quiet, beautiful, clean, everything you need while not being far away from a small town. Can't recommend this place enough. After just one hour, my wife and I said we need to come back here at least once a year if not more.Even though the weather was against us being in the upper 90's in September, sitting out on the porch you could barely tell.....such a great place and can't wait to see this in the winter time!!!!"

Big Sky Cabin! Hot Tub! Fire Pit! Pool Table! Private! Can hold Large Groups

10/10 Excellent

"Beautiful home with a great game room. Close to wineries with a private setting. Perfect getaway."