Perryville Vacation Rentals

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Check prices for these dates

In two weeks
Dec 19 - Dec 21
In two months
Jan 30 - Feb 1
In three months
Feb 27 - Mar 1
In four months
Mar 27 - Mar 29

Vacation Rentals in Perryville

55-inch Smart TV with digital channels, TV, streaming services
Urban Lofts

Aparthotel in Perryville

3.0 star property
9.2 out of 10, Wonderful, (17)
"Great place to stay! "
United States
Eric
$208 nightly
The price is $238
Dec 31 - Jan 1, 2026
Total with taxes and fees
Urban Lofts
Property grounds
TreeLoft at BaseCamp

Cabin in Perryville

2.0 star property
10.0 out of 10, Exceptional, (5)
"This place is perfect if you want a private upscale experience that is immersed in natural beauty. The treehouse is luxurious and so comfortable. We loved every minute of our stay. "
United States
joel r.
$417 nightly
The price is $439
Dec 9 - Dec 10
Total with taxes and fees
TreeLoft at BaseCamp
Interior
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Apartment in Perryville

10.0 out of 10, Exceptional, (1)
"Everything was perfect!"
United States
Thor L.
$277 nightly
The price is $317
Dec 8 - Dec 9
Total with taxes and fees
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
Interior
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques

Apartment in Perryville

2.0 star property
$185 nightly
The price is $213
Dec 8 - Dec 9
Total with taxes and fees
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques
Interior
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques

Apartment in Perryville

$230 nightly
The price is $264
Dec 31 - Jan 1, 2026
Total with taxes and fees
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques
Interior
Downtown Urban Loft above Restaurants

Apartment in Perryville

2.0 star property
$240 nightly
The price is $274
Dec 19 - Dec 20
Total with taxes and fees
Downtown Urban Loft above Restaurants
Interior
Gorgeous, downtown house!

Apartment in Perryville

10.0 out of 10, Exceptional, (1)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
$771 nightly
The price is $875
Dec 8 - Dec 9
Total with taxes and fees
Gorgeous, downtown house!
Fridge, microwave, oven, stovetop
Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress

Mobile Home in Oraville

9.0 out of 10, Wonderful, (2)
"If used for hunting, maybe have a set up for cleaning of game ."
United States
john l.
$189 nightly
The price is $200
Dec 31 - Jan 1, 2026
Total with taxes and fees
Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress
TV, fireplace
The Cottage, Rusted Route Farms

Mobile Home in Jackson

10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
$195 nightly
The price is $195
Dec 9 - Dec 10
Total with taxes and fees
The Cottage, Rusted Route Farms
Outdoor pool
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Mobile Home in Fredericktown

2.0 star property
$267 nightly
The price is $267
Dec 31 - Jan 1, 2026
Total with taxes and fees
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
Fridge, microwave, oven, stovetop
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

Cottage in Ste. Genevieve

2.0 star property
10.0 out of 10, Exceptional, (17)
"Great historic property!"
United States
Rhonda R.
$182 nightly
The price is $182
Dec 9 - Dec 10
Total with taxes and fees
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
Outdoor dining
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington

Vacation Home in Farmington

2.0 star property
10.0 out of 10, Exceptional, (11)
"Great place and very comfortable! Hosts were super attentive when our door code didn’t work and got us sorted out right away. "
United States
Kyser B.
$219 nightly
The price is $230
Dec 9 - Dec 10
Total with taxes and fees
"The Hideaway 1" Charming 2-bedroom house with WiFi, AC in fabulous Farmington
Fridge, microwave, oven, stovetop
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Vacation Home in Farmington

8.6 out of 10, Excellent, (4)
"Great place. "
United States
Diana
$138 nightly
The price is $138
Dec 8 - Dec 9
Total with taxes and fees
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Private kitchen
Cozy 1-bedroom house with AC and WiFi in charming Farmington

Vacation Home in Farmington

10.0 out of 10, Exceptional, (6)
"Absolutely LOVED it here! Hope to return in 2026. Karli made my first Vrbo experience just plain splendid!"
United States
Tru L.
$179 nightly
The price is $185
Dec 8 - Dec 9
Total with taxes and fees
Cozy 1-bedroom house with AC and WiFi in charming Farmington
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Apartment in Ste. Genevieve

10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
$168 nightly
The price is $179
Dec 10 - Dec 11
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
Outdoor dining
Beautiful location in the secluded woods

Vacation Home in Pomona

10.0 out of 10, Exceptional, (60)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
$141 nightly
The price is $150
Dec 8 - Dec 9
Total with taxes and fees
Beautiful location in the secluded woods
2 bedrooms
The Lab! Come stay in our brand new space.

Apartment in Murphysboro

9.4 out of 10, Exceptional, (19)
"We were in town for a wedding, and this was the perfect place to stay. The Vrbo was well-stocked with everything you may need and very clean."
United States
Sean G.
$192 nightly
The price is $203
Dec 8 - Dec 9
Total with taxes and fees
The Lab! Come stay in our brand new space.
Exterior detail
Gorgeous 1856 Log Cabin, Completely Renovated

Cabin in Jackson

10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
$310 nightly
The price is $310
Dec 8 - Dec 9
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
Outdoor dining
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

Vacation Home in Farmington

2.0 star property
10.0 out of 10, Exceptional, (8)
"It is a very nice place and very comfortable has everything you could possibly need for homeaway from home."
United States
Scott
$216 nightly
The price is $227
Jan 4 - Jan 5, 2026
Total with taxes and fees
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Fridge, microwave, oven, stovetop
Relax in the country at Countryside Villas! - Villa A

Apartment in Jackson

10.0 out of 10, Exceptional, (33)
"Great place to stay, felt like home away from home. "
United States
Brittany
$170 nightly
The price is $183
Dec 8 - Dec 9
Total with taxes and fees
Relax in the country at Countryside Villas! - Villa A
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perryville Hotel Reviews

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

10/10 Excellent
"The staff were wonderful and helpful."
Spenser 1-night trip
Posted 1 day ago
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Find out more about Perryville

Everything you need to know about Perryville vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Perryville vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Perryville vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Perryville vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Perryville. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Perryville in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $150 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Perryville rentals

At Expedia, we put the best Perryville vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Perryville rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Perryville vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Perryville. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Perryville?

Yes, you can find vacation rentals near top local attractions in Perryville, or you can choose a more secluded option if you'd like a relaxing place to stay. Perryville is known for its wineries and golf courses. Make sure you have time to check out the coffeehouses and festivals during your trip.

What are some of the best vacation rentals that Perryville has to offer?

Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.: This vacation home rental outside of Perryville is located in a rural location and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals will I find in Perryville?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Perryville stay.

What’s there to see and do in Perryville?

Mark Twain National Forest and Mississippi River are a couple of lovely local spots to get outside and enjoy nature. While here, National Shrine of Our Lady of the Miraculous Medal and Perryville Country Club are other places worth a visit.

What’s a vacation rental in Perryville like?

Vacation rentals are privately owned properties you can book for short or long periods in Perryville. Vacation rentals offer amenities such as laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about a clean environment, vacation rentals can provide a sense of security away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for family gatherings.