San Luis Vacations from $358

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

The Latest San Luis vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Provenza Garden

Hotel Provenza Garden

3 out of 5
El Poblado
Save 100% on your flight
per person
Sep 20 - Sep 26
found 1 day ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
8.2/10 Very Good! (145 reviews)
The hotel is right at the middle of all the actions e.g. bars, restaurants, nightclubs etc. It’s in a very safe area in Barrio Provenza in El Poblado. The room is so spacious. All the staff are so friendly and willing to help. The hotel is so clean. I recommend Hotel Provenza Garden and I would definitely come back to stay here if I come to Medellin.

Reviewed on Jul 1, 2025

Cannúa Lodge

Cannúa Lodge

4 out of 5
Save 100% on your flight
per person
Aug 31 - Sep 7
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Medellín (MDE)
9/10 Wonderful! (28 reviews)
Great way to get away fom the hustle of daily life. Enjoyed time with my family (including 2 kids). the staff is excellent. food is great!

Reviewed on Mar 24, 2025

EP Casa Uribe Architecture Art & Nature

EP Casa Uribe Architecture Art & Nature

4 out of 5
El Poblado
Save 100% on your flight
per person
Sep 17 - Sep 21
found 14 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
10/10 Exceptional! (1 review)
The house is extremely comfortable and spacious. Luxury amenities that made us feel at home. The pool, jacuzzi and sauna. Graciela the house keeper and Charles our private chef made our stay amazing. It was nice that they had a lunch and dinner menu available for those days we wanted to stay in. Probably one of the best stays in Medellin. The location is just minutes away from Provenza and surroundings. Manuela the host was super attentive, helping us with reservations at restaurants.

Reviewed on Mar 24, 2025

EL NIDO HOTEL GUATAPE

EL NIDO HOTEL GUATAPE

3 out of 5
Save 100% on your flight
per person
Aug 17 - Aug 23
found 1 day ago
Roundtrip flight included
San Juan (SJU) to Medellín (MDE)
10/10 Exceptional! (3 reviews)
Great location. 10 minutes from town.Right on the lake view of the "rock". Super attentive staff. Extremely friendly & accomodating too. Kevin in particular is excellent. Very beautiful and tranquil grounds .

Reviewed on May 23, 2025

Sotavento Cabañas

Sotavento Cabañas

3 out of 5
Save 100% on your flight
per person
Sep 20 - Sep 26
found 23 hours ago
Roundtrip flight included
Fort Lauderdale (FLL) to Medellín (MDE)
9.8/10 Exceptional! (48 reviews)
The view from the room was terrific, and there was easy access to the water. Floaties and kayaks were available to use. The food was okay. (I’m vegetarian, so all I had was fresh juice and grilled cheese, and the bread was decent.)

Reviewed on Jun 23, 2025

Don't see what you're looking for?
See all available trips from Columbus to San Luis
View all trips

Discover the most popular places to visit in San Luis

El Balseadero Nature Park

You can take time to visit El Balseadero Nature Park during your travels to San Luis.

El Balseadero Nature Park

La Planta Waterfall

Commune with nature and explore the great outdoors at La Planta Waterfall during your travels in San Luis.

La Planta Waterfall

What to do in San Luis

La Cuba WATERFALL RAPPELLING and La Planta GIANT NATURAL POOL from MEDELLIN

La Cuba WATERFALL RAPPELLING and La Planta GIANT NATURAL POOL from MEDELLIN

$380
per adult
La Cuba WATERFALL RAPPELLING and La Planta GIANT NATURAL POOL from MEDELLIN
Hacienda Napoles - Theme park

Hacienda Napoles - Theme park

$100
per adult
Hacienda Napoles - Theme park
Admission to the Hacienda Naples Theme Park

Visit Hacienda Naples Park by Pablo Escobar

$93
per adult
Visit Hacienda Naples Park by Pablo Escobar
See all activities in San Luis

San Luis Hotel Deals

The Brown, Guatape, Autograph Collection

The Brown, Guatape, Autograph Collection

4 out of 5
El Peñol, Guatapé, Antioquia
Fully refundableReserve now, pay when you stay
$164 nightly
The price is $164 total per night from Jul 22 to Jul 23
$164 total
Jul 22 - Jul 23
9/10 Wonderful! (306 reviews)
Incredible oasis of a hotel at Guatape
"The hotel was incredible, really beautiful, the pool and hot tubs were fantastic. Loved the views. The restaurant was good as well. We did the water sports and enjoyed the jet skis at the hotel as well. It felt like an oasis Highly recommend!"

Reviewed on Jul 13, 2025

The Brown, Guatape, Autograph Collection
BubbleSky Glamping Guatapé

BubbleSky Glamping Guatapé

3 out of 5
Guatape - El Anillo 3 kms, Ingresando por la piedra, Guatapé, Colombian Peso
Fully refundable
$97 nightly
The price is $97 total per night from Jul 21 to Jul 22
$97 total
Jul 21 - Jul 22
8.8/10 Excellent! (65 reviews)
"Espectacular el lugar y el persoal"

Reviewed on Jun 16, 2025

BubbleSky Glamping Guatapé
Hotel Los Recuerdos

Hotel Los Recuerdos

3.5 out of 5
Via Peñol Gatapé Km 19, Guatapé, Antioquia
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $78 total per night from Jul 20 to Jul 21
$78 total
Jul 20 - Jul 21
8/10 Very Good! (528 reviews)
"Very friendly and very beatiful view"

Reviewed on Jun 20, 2025

Hotel Los Recuerdos
See all 563 properties in San Luis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best San Luis Vacation Packages

San Luis Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Jose Maria Cordova Intl. Airport (MDE)

More vacations you might like

Frequently asked questions

How much does a San Luis vacation package cost?
You can pick up a vacation package to this top destination from $358 on Expedia. But how much your vacation to San Luis costs will depend on factors like the length of stay, hotel choice and season.
What are the cheapest months to go to San Luis?
You're likely to find lower rates and greater availability in November, December and January. Explore our cheap San Luis vacation packages and you could get some great off-season deals.
How many days is enough for San Luis?
Typically, a handful of days is enough to go to the major attractions during your San Luis vacation. But if you want to have some time to rest or take day tours, think about extending your itinerary.
How to find the best San Luis package deals?
Finding a cheap San Luis package deal is a cinch with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your maximum budget, apply some filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most affordable San Luis package deals. Want a simple trick to score the biggest savings? Be flexible with your departure dates and consider going away on a weekday, when prices are typically lower.
Is it cheaper to book a San Luis vacation as a package?
An Expedia vacation package could land you great savings when compared to booking flights and stays individually. Better still, you can personalize your San Luis trip to match your exact needs. Choose your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to San Luis?
If you're planning an impromptu San Luis vacation, browse our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score terrific deals on your flights and hotels by booking ahead.
How to plan a trip to San Luis?

  1. Choose the perfect time to travel: Your schedule, favorite season and the type of weather you like can all influence your decision on when to visit San Luis.
  2. Budget wisely: As well as the price of your accommodations, you'll need to consider other expenses too. These include transportation, food and flights. Also, set aside some extra funds for unexpected expenses that may come up during your trip to San Luis.
  3. Organize your San Luis getaway with Expedia's trip planning tool: Search for and book hotels and activities all in one place. You can also collaborate with friends and family to plan an unforgettable trip to San Luis together.
  4. Decide how long to go for: Now that you're more familiar with San Luis, you can figure out the perfect length of your break. Create a draft plan and allocate enough time to get through everything on your must-do list.
  5. Combine your accommodations and airfare: Once you've settled on your trip dates and duration, book the perfect San Luis vacation package for you.
  6. Book activities and experiences ahead of time: Whether it's entrance to a big attraction or a day trip, you won't have to worry about missing out on the highlights of San Luis. Find all the fun things to do in San Luis with our dedicated travel guide.

Does Expedia offer Book Now, Pay Later San Luis vacation packages?
Your San Luis getaway should be an escape from your busy life, not a source of money worries. So to give you more flexibility, we've teamed up with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there are no hidden or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.