Sant'Eustachio Vacations from $655

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Your SantEustachio Vacation

A well-liked picturesque neighborhood, SantEustachio is all about cafes, history and bars and pubs. Lock in a vacation package to SantEustachio and get set to discover all of that and more. Start your trip to SantEustachio by checking out nearby attractions such as St. Peters Basilica, Roman Forum and Pantheon. Stop daydreaming and start doing. When you're ready to book your dream vacation to SantEustachio, Expedia is here to help.

The Latest Sant'Eustachio Vacation Packages

Price found within the past 48 hours. Click for updated prices.
LH Hotel Lloyd Rome

LH Hotel Lloyd Rome

3 out of 5
Salario
Price was $976, price is now $655 per person
$655
per person
Nov 19 - Nov 25
found 10 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (658 reviews)
Staff were friendly but hotel need a up date put power plugs in one area socket came out it was clean but some need to be repaired

Reviewed on Jul 7, 2025

CC Palace Hotel Roma

CC Palace Hotel Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,290, price is now $790 per person
$790
per person
Dec 7 - Dec 12
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.8/10 Exceptional! (351 reviews)
I loved the service from the minute we arrived to the minute we checked out. The staff are friendly and jovial. The facility was topnotch.

Reviewed on Sep 22, 2025

Vibe Nazionale

Vibe Nazionale

3 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,514, price is now $977 per person
$977
per person
Nov 15 - Nov 22
found 5 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
8/10 Very Good! (63 reviews)
Very small room no toiletries,poor breakfast

Reviewed on Sep 21, 2025

TB Place Roma

TB Place Roma

4 out of 5
Rome City Centre
Save 100% on your flight
Price was $1,833, price is now $1,221 per person
$1,221
per person
Dec 7 - Dec 12
found 12 hours ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.2/10 Wonderful! (43 reviews)
We pretty much likes everything about the property. My wife and I travel a lot and normally go to very good hotels which are bigger, but we wanted to try a boutique hotel this time and it did not disappoint. We stayed for 6 nights. For starters, their people are wonderful, with a special shout out to Martina at the front desk and the young lady that runs the breakfast (we should know her name). The location is great, the hotel is in great condition. We stayed in a junior suite and it was a really good size. We tend to be on the picky side, and honestly we can’t find anything bad to say. Keep it up!

Reviewed on Jun 1, 2025

Tree Charme Augusto Boutique Hotel

Tree Charme Augusto Boutique Hotel

3 out of 5
Rome City Centre
Price was $963, price is now $683 per person
$683
per person
Dec 7 - Dec 12
found 1 day ago
Roundtrip flight included
New York (JFK) to Rome (FCO)
9.4/10 Exceptional! (19 reviews)
I stayed from September 17 - 19th, 2025. I absolutely loved the hotel, its in an excellent lo

Reviewed on Sep 20, 2025

Where to stay in Sant'Eustachio

Find the best Sant'Eustachio areas and neighborhoods for the activities you enjoy most. Learn more about Sant'Eustachio
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

8 out of top 10 points of interest in this area
4.5/5(3,994 area reviews)

Follow in the footsteps of ancient Romans when you tour the Eternal City's most well-known historical sites and see where it started almost 3,000 years ago.

Find hotels in Rome City Centre

Sant'Eustachio Hotel Deals

Argentina Residenza Style Hotel

Argentina Residenza Style Hotel

4 out of 5
Via di Torre Argentina 47, Rome, RM
Fully refundableReserve now, pay when you stay
$290 nightly
The price is $337 total per night from Nov 2 to Nov 3
$337 total
Nov 2 - Nov 3
Total with taxes and fees
9.2/10 Wonderful! (1,027 reviews)
"Clean room and friendly staff"

Reviewed on Sep 29, 2025

Argentina Residenza Style Hotel
Hotel Navona

Hotel Navona

3 out of 5
Via dei Sediari 8, Rome, RM
$149 nightly
The price is $178 total per night from Nov 2 to Nov 3
$178 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (996 reviews)
"Great location for walking to all of the major sites (Vatican City, Colosseum, Trevi Fountain, Spanish Steps, just minutes from Pantheon). It was terribly warm weather the week we visited and the air conditioning was wonderful! One morning we had the breakfast at the hotel - similar to continental ..."

Reviewed on Oct 1, 2025

Hotel Navona
Hotel L'Orologio Roma

Hotel L'Orologio Roma

4 out of 5
Corso Vittorio Emanuele II n. 110, Rome, RM
Fully refundableReserve now, pay when you stay
$326 nightly
The price is $376 total per night from Nov 3 to Nov 4
$376 total
Nov 3 - Nov 4
Total with taxes and fees
9.4/10 Exceptional! (395 reviews)
"Great staff"

Reviewed on Sep 22, 2025

Hotel L'Orologio Roma
See all 15,748 properties in Sant'Eustachio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Sant'Eustachio

Palazzo Madama

Palazzo Madama

After visiting Palazzo Madama, make a plan to see the other sights and activities in Rome. Stroll along the riverfront or visit the notable monuments in this vibrant area.

Palazzo Madama
Sant'Ivo alla Sapienza

Sant'Ivo alla Sapienza

You can learn about the history of Rome with a stop at Sant'Ivo alla Sapienza. Discover the acclaimed art scene and stunning cathedral in this vibrant area.

Sant'Ivo alla Sapienza

Sant'Eustachio

You can learn about the history of Rome when you stop by Sant'Eustachio. Stroll along the riverfront or experience the fascinating museums in this vibrant area.

Sant'Eustachio

Things to do

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica

$40
per adult
88% of travellers recommend
Skip-the-Line Group Tour of the Vatican, Sistine Chapel & St. Peter's Basilica
Rome Hop-On Hop-Off Big Bus Tour

Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus

$34
per adult
82% of travellers recommend
Rome Big Bus Hop-on, Hop-off Tour by Open-top Bus
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour

$35
per adult
84% of travellers recommend
Rome: Colosseum with Arena, Roman Forum and Palatine Guided Tour
See all activities in Rome
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.