Santa Cruz Vacations from $1,375
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Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Eurostars Al-Ándalus Palace
Bellavista-La Palmera
Price was $1,784, price is now $1,375 per person
$1,375
per person
May 18 - May 24
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
8.6/10 Excellent! (1,183 reviews)
Everything i needed was easily reachable.
Public transport is timely, inexpensive and safe.
The staff are friendly and helpful.
My only regret was that the pool was closed.
It looked so good. Doesn't open till June.
So i took a day trip to the beach (Rota) and had my swim there.
So everything worked out good.
Reviewed on Apr 5, 2026
Eurostars Sevilla Boutique
Historical Center
Price was $2,649, price is now $1,805 per person
$1,805
per person
May 18 - May 24
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
9/10 Wonderful! (507 reviews)
Perfect location. Beautiful hotel. Very Clean and the best staff.
Reviewed on Mar 24, 2026
Exe Sevilla Macarena
Macarena
Price was $1,909, price is now $1,437 per person
$1,437
per person
May 18 - May 24
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
8/10 Very Good! (1,000 reviews)
Room didnt smell good, would be nice if they have coffee in the room or vendo machine for hot bevereges in the lobby. Happy that they have vendo machine for cold drinks. Asked for a wakeup call but never got it. You can hear the voices and snoring of the people next door.
Reviewed on Feb 13, 2026
Becquer Hotel, Historic City Center
Historical Center
Price was $2,410, price is now $1,840 per person
$1,840
per person
May 18 - May 24
found 5 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Seville (SVQ)
9.6/10 Exceptional! (1,003 reviews)
Great hotel. walking distance to most of the city's points of interest. The parking was available at the property for an extra charge but there is also public parking near by.
Reviewed on Apr 7, 2026
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
7 out of top 10 points of interest in this area
4.5/5(606 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $237 total per night from Apr 12 to Apr 13
$237 total
Apr 12 - Apr 13
Total with taxes and fees
9.2/10 Wonderful! (1,005 reviews)
Staying at this hotel is an adventure in history. To think that we walked the same paths as Christoper Columbus and crew was humbling and gave us a sense of Sevilla’s role in bridging the new world with the old. The hotel is centrally located in the Santa Cruz neighborhood close to all of the must ...
Reviewed on Apr 2, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$715 nightly
The price is $786 total per night from Apr 27 to Apr 28
$786 total
Apr 27 - Apr 28
Total with taxes and fees
Hotel Fernando III
San Jose 21 Seville Seville
$252 nightly
The price is $277 total per night from Apr 16 to Apr 17
$277 total
Apr 16 - Apr 17
Total with taxes and fees
9.6/10 Exceptional! (1,490 reviews)
The breakfast was fine
Reviewed on Apr 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$45
per adult
92% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
$29
per adult
86% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
$79
per adult
100% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.