Santa Cruz Vacations
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Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
7 out of top 10 points of interest in this area
4.5/5(600 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Hotel Fernando III
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$210 nightly
The price is $231 total per night from Mar 23 to Mar 24
$231 total
Mar 23 - Mar 24
Total with taxes and fees
9.6/10 Exceptional! (1,491 reviews)
Fantastic location. Very clean and modern rooms. Breakfast buffet is very complete with excellent choices.
Reviewed on Mar 11, 2026
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$191 nightly
The price is $210 total per night from Mar 22 to Mar 23
$210 total
Mar 22 - Mar 23
Total with taxes and fees
9.2/10 Wonderful! (1,002 reviews)
Didn't usr pool or spa
Reviewed on Mar 14, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
$667 nightly
The price is $734 total per night from Apr 6 to Apr 7
$734 total
Apr 6 - Apr 7
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
Staff
Reviewed on Feb 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$39
per adult
92% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
$81
per adult
100% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
$58
per adult
96% of travellers recommend
Explore a world of travel with Expedia
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.