Santa Cruz Vacations from $2,021

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Las Casas de El Arenal by Casas y Palacios

Hotel Las Casas de El Arenal by Casas y Palacios

4 out of 5
Historical Center
Price was $2,605, price is now $2,021 per person
$2,021
per person
May 3 - May 9
found 22 hours ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9.4/10 Exceptional! (980 reviews)
An excellent hotel. Staff professional and welcoming, went above and beyond in their service. Good breakfast. Lots of charm in the architecture, unlike many of the souless Stalinist places we've been to in the past.

Reviewed on Jan 31, 2026

Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Historical Center
Price was $3,968, price is now $3,097 per person
$3,097
per person
May 3 - May 9
found 22 hours ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9.8/10 Exceptional! (896 reviews)
Charming place deep in Old Seville, with super-helpful staff, fluent in English. Great rooftop view of Cathedral at sunset. Room was elegant yet comfortable. It opens onto the internal courtyard, which limits privacy a bit, but no biggie for us. Location is hard to find deep in the car-free section of old town, but worth it!

Reviewed on Mar 31, 2026

Eurostars Sevilla Boutique

Eurostars Sevilla Boutique

4 out of 5
Historical Center
Price was $3,654, price is now $2,932 per person
$2,932
per person
May 27 - Jun 2
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9/10 Wonderful! (506 reviews)
Perfect location. Beautiful hotel. Very Clean and the best staff.

Reviewed on Mar 24, 2026

Hotel Kivir Adults Recommended, Historic City Center

Hotel Kivir Adults Recommended, Historic City Center

4 out of 5
Historical Center
Price was $2,604, price is now $2,095 per person
$2,095
per person
May 3 - May 9
found 22 hours ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9.8/10 Exceptional! (565 reviews)
This hotel was very, very nice! It is adults only which we appreciated. The staff was very attentive and accommodating. The only thing I have to say is that there are fragrance reeds in all the rooms and also pumped into the hallways. So if you have a fragrance issue, I would ask them to remove any reeds before you get there. Other than that you are in the middle of everything! You’re steps away from the Isabel Bridge to take you to Triana. Everything else was walking distance as you are centrally located. They have a great rooftop bar that we used and enjoyed the views of the guadalkivir river! we came at the end of March and the weather was perfect for sightseeing and walking all over this very walkable city

Reviewed on Mar 24, 2026

Eurostars Guadalquivir

Eurostars Guadalquivir

4 out of 5
Los Remedios
Price was $3,162, price is now $2,687 per person
$2,687
per person
May 27 - Jun 2
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9.4/10 Exceptional! (562 reviews)
Very well located hotel

Reviewed on Mar 30, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$216 nightly
The price is $238 total per night from Apr 6 to Apr 7
$238 total
Apr 6 - Apr 7
Total with taxes and fees
9.2/10 Wonderful! (1,005 reviews)
Staying at this hotel is an adventure in history. To think that we walked the same paths as Christoper Columbus and crew was humbling and gave us a sense of Sevilla’s role in bridging the new world with the old. The hotel is centrally located in the Santa Cruz neighborhood close to all of the must ...

Reviewed on Apr 2, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$232 nightly
The price is $255 total per night from Apr 6 to Apr 7
$255 total
Apr 6 - Apr 7
Total with taxes and fees
9.6/10 Exceptional! (1,494 reviews)
The staff were amazing, clean room everytime I returned and best part is the champagne they sent to my room for my birthday even though I didn’t mention it to them. It’s the details they pay attention to. I felt safe as well for a lady traveling solo.

Reviewed on Mar 31, 2026

Hotel Fernando III
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$667 nightly
The price is $733 total per night from Apr 6 to Apr 7
$733 total
Apr 6 - Apr 7
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Staff

Reviewed on Feb 27, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
See all 436 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Alone in the Alcazar: Exclusive Early Access Tour

Alone in the Alcazar: Exclusive Early Access Guided Tour

$119
per adult
100% of travellers recommend
Alone in the Alcazar: Exclusive Early Access Guided Tour
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

$29
per adult
86% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$79
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
See all activities in Seville

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