Santa Cruz Vacations

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

Price found within the past 48 hours. Click for updated prices.
  • Exterior
    Aug 17 - Aug 28

    Eurostars Conquistador Hotel + Flight

    Córdoba Old City
    10 nights
    4.0 star property
    8.8/10 - Excellent (1,001 reviews)
    "Really nice hotel with a nice size room, great breakfast, very accommodating staff, and most importantly, right in the middle of everything. All attractions and historical sites are walking distance and easily reachable. I definitely stay here again!"
    Reviewed May 22, 2026
    Roundtrip • New York (EWR) - Seville (SVQ)
    EWR - SVQ • 1 stop SVQ - EWR • 1 stop
    $1,548
    $1,262
    per traveler
    found 11 hours ago
    Eurostars Conquistador Hotel
  • Lobby
    Aug 17 - Aug 28

    Eurostars Palace Hotel + Flight

    Distrito Centro
    10 nights
    5.0 star property
    9.0/10 - Wonderful (1,011 reviews)
    "Wonderful employees working there from receptions,restaurant to house keeping,we were felt like home,all questions were patiently answered and helped,breakfast was offered us when checked in, it was super good,variety of fresh made foods,location was great,close to the historic Centre,we can highly recomend."
    Reviewed May 31, 2026
    Roundtrip • New York (EWR) - Seville (SVQ)
    EWR - SVQ • 1 stop SVQ - EWR • 1 stop
    $1,806
    $1,399
    per traveler
    found 11 hours ago
    Eurostars Palace Hotel
  • Sundeck
    Aug 3 - Aug 7

    Aguilas5 SevillaSuites + Flight

    Historical Center
    3 nights
    4.0 star property
    10/10 - Exceptional (528 reviews)
    "Service was great. They were very response and addressed our concerns. But the property is more 3 stars than 4. We had two small beds together in one room. My wife’s bed was slipping from the end so 20-30 pct was unusable and mattress should be replaced. Bathroom also had duct tape on the ceiling and the shower is barely 2 feet wide. I couldn’t shower without hitting my hand somewhere. Location is great but I wouldn’t stay here again. Would look for an actual 4 star hotel."
    Reviewed April 5, 2026
    Roundtrip • Miami (MIA) - Seville (SVQ)
    MIA - SVQ • 1 stop SVQ - MIA • 1 stop
    $1,689
    $1,333
    per traveler
    found 1 day ago
    Aguilas5 SevillaSuites
  • Terrace/patio
    Aug 17 - Aug 28

    Tandem Mezquita + Flight

    La Catedral
    10 nights
    2.0 star property
    9.6/10 - Exceptional (4 reviews)
    "The place was clean, and spacious... I will add it was immaculate. People all around where great. I would stay there again, no problem."
    Reviewed May 26, 2026
    Roundtrip • New York (EWR) - Seville (SVQ)
    EWR - SVQ • 1 stop SVQ - EWR • 1 stop
    $1,583
    $1,280
    per traveler
    found 11 hours ago
    Tandem Mezquita
  • Interior entrance
    Jul 12 - Jul 26

    Hotel ILUNION Alcora Sevilla + Flight

    San Juan de Aznalfarache
    13 nights
    4.0 star property
    8.6/10 - Excellent (1,005 reviews)
    "Amazing very clean and amazing views"
    Reviewed May 29, 2026
    Roundtrip • Miami (MIA) - Seville (SVQ)
    MIA - SVQ • 1 stop SVQ - MIA • 1 stop
    $2,212
    $1,852
    per traveler
    found 1 day ago
    Hotel ILUNION Alcora Sevilla

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$709 nightly
The price is $780 total per night from Jun 24 to Jun 25
$780 total
Jun 24 - Jun 25
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
"The breakfast bar offered a nice selection of foods. For dinner, I had the best Flan I’ve ever eaten"

Reviewed on May 17, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $74 total per night from Jun 28 to Jun 29
$74 total
Jun 28 - Jun 29
Total with taxes and fees
8.8/10 Excellent! (1,010 reviews)
"La terrasse sur le toit était très charmante. Le petit déjeuner offert est excellent et très varié."

Reviewed on May 27, 2026

Hotel Murillo
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $140 total per night from Jul 2 to Jul 3
$140 total
Jul 2 - Jul 3
Total with taxes and fees
9.2/10 Wonderful! (1,005 reviews)
"Hotel was ideally located in the historic part of the city . It was unique with its tunnel access to rooms and internal courtyards added to its charm. It had a calm peaceful air that didn’t reflect its central location. Staff very helpful and charming. The roof top pool was a delightful place to ..."

Reviewed on Jun 1, 2026

Las Casas de la Judería, Sevilla Historic City Center
See all 431 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$39
per adult
90% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

$29
per adult
88% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$81
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
See all activities in Seville

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