Santa Cruz Vacations from $458

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Apartamentos Metrópolis Sevilla

Apartamentos Metrópolis Sevilla

3 out of 5
Historical Center
Save 100% on your flight
Price was $683, price is now $458 per person
$458
per person
Apr 22 - Apr 24
found 1 day ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
8.8/10 Excellent! (179 reviews)
The location of this apartment is perfect - close to all touristic locations and pretty decent dining options etc.

Reviewed on Dec 23, 2025

Eurostars Guadalquivir

Eurostars Guadalquivir

4 out of 5
Los Remedios
Save 100% on your flight
Price was $1,100, price is now $655 per person
$655
per person
May 9 - May 15
found 20 hours ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
9.4/10 Exceptional! (562 reviews)
Super close restaurants, check in was nice and easy and staff was super nice and helpful

Reviewed on Mar 8, 2026

Eurostars Sevilla Boutique

Eurostars Sevilla Boutique

4 out of 5
Historical Center
Save 100% on your flight
Price was $1,180, price is now $794 per person
$794
per person
May 11 - May 15
found 4 hours ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
9/10 Wonderful! (506 reviews)
We very much enjoyed our stay here. Excellent location. I would recommend.

Reviewed on Jan 17, 2026

Exe Sevilla Macarena

Exe Sevilla Macarena

4 out of 5
Macarena
Save 100% on your flight
Price was $740, price is now $519 per person
$519
per person
May 11 - May 15
found 4 hours ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
8/10 Very Good! (1,006 reviews)
Room didnt smell good, would be nice if they have coffee in the room or vendo machine for hot bevereges in the lobby. Happy that they have vendo machine for cold drinks. Asked for a wakeup call but never got it. You can hear the voices and snoring of the people next door.

Reviewed on Feb 13, 2026

Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Historical Center
Save 100% on your flight
Price was $1,614, price is now $1,158 per person
$1,158
per person
May 9 - May 15
found 20 hours ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
9.6/10 Exceptional! (1,161 reviews)
This is an excellent hotel with beautiful common areas Excellent breakfast Great laundry service Great location but be prepared to walk

Reviewed on Mar 18, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

8 out of top 10 points of interest in this area
4.5/5(600 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$193 nightly
The price is $212 total per night from Mar 22 to Mar 23
$212 total
Mar 22 - Mar 23
Total with taxes and fees
9.2/10 Wonderful! (1,007 reviews)
We enjoyed our stay at Las Casas de la Juderia. The staff were very kind and helpful. Our only critique is that the room was a bit noisy and did not block outside sound very well.

Reviewed on Mar 17, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
$221 nightly
The price is $244 total per night from Mar 26 to Mar 27
$244 total
Mar 26 - Mar 27
Total with taxes and fees
9.6/10 Exceptional! (1,493 reviews)
Staff were very friendly and it was really lovely that they sorted some fizz for my friend's birthday. Roof top terrace was really nice and breakfast had lots of choice. Only downsides were the room only had a very small internal window which made it feel a bit claustrophobic. Also a shame for the ...

Reviewed on Mar 17, 2026

Hotel Fernando III
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$581 nightly
The price is $639 total per night from Apr 14 to Apr 15
$639 total
Apr 14 - Apr 15
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Staff

Reviewed on Feb 27, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
See all 432 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in Santa Cruz

Royal Alcázar showing a church or cathedral and religious elements

Royal Alcázar of Seville

5/5(735 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
La Giralda which includes a castle and heritage architecture

Giralda Tower

4.5/5(496 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace which includes heritage architecture

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$39
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$81
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

$58
per adult
96% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.