Santa Cruz Vacations from $169
Book a Hotel + Flight or Car together to unlock savings
Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Exe Gran Hotel Solúcar
Save 100% on your flight
Price was $265, price is now $169 per person
$169
per person
Jul 8 - Jul 11
found 20 hours ago
Roundtrip flight included
Madrid (MAD) to Seville (SVQ)
7.8/10 Good! (447 reviews)
breakfast was good. Only one language cart for entire hotel. Lot of public area but not open for customer to sit, eat and relax.
Reviewed on Apr 10, 2026
Cavalta Boutique Hotel – Small Luxury Hotel
Triana
Save 100% on your flight
Price was $682, price is now $374 per person
$374
per person
Jul 8 - Jul 11
found 21 hours ago
Roundtrip flight included
Madrid (MAD) to Seville (SVQ)
9.8/10 Exceptional! (101 reviews)
Absolutely loved everything about this hotel. Staff are very welcoming and friendly, the food is great - breakfast is exceptional. Would definitely return if we come back to Seville
Reviewed on Apr 11, 2026
Exe Sevilla Macarena
Macarena
Save 100% on your flight
Price was $392, price is now $232 per person
$232
per person
Jul 8 - Jul 11
found 20 hours ago
Roundtrip flight included
Madrid (MAD) to Seville (SVQ)
8/10 Very Good! (1,000 reviews)
Parking needs to be prebooked but the hotel listing on Expedia doesn't tell you. So you have to find public parking which is difficult in Seville
Reviewed on Apr 10, 2026
Hotel Boutique Corral del Rey by ALUZ Collection
Historical Center
Save 100% on your flight
Price was $878, price is now $524 per person
$524
per person
Jul 8 - Jul 11
found 21 hours ago
Roundtrip flight included
Madrid (MAD) to Seville (SVQ)
9.8/10 Exceptional! (125 reviews)
Clean room, nice location, and superb service
Reviewed on Apr 10, 2026
Joya del Casco Boutique Hotel
Historical Center
Save 100% on your flight
Price was $479, price is now $305 per person
$305
per person
Jul 8 - Jul 11
found 20 hours ago
Roundtrip flight included
Madrid (MAD) to Seville (SVQ)
9.6/10 Exceptional! (211 reviews)
Breakfast was fine good selection.
Reviewed on Mar 27, 2026
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
7 out of top 10 points of interest in this area
4.5/5(606 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
$230 nightly
The price is $253 total per night from Apr 19 to Apr 20
$253 total
Apr 19 - Apr 20
Total with taxes and fees
9.2/10 Wonderful! (1,016 reviews)
The hotel was very unique and fun. Has underground tunnels that connect the rooms with numerous plazas with plants and interesting artifacts to relax. Great location!
Reviewed on Apr 14, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
$717 nightly
The price is $789 total per night from Apr 27 to Apr 28
$789 total
Apr 27 - Apr 28
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Simply amazing property. Amazing service
Reviewed on Apr 8, 2026
Hotel Fernando III
San Jose 21 Seville Seville
$262 nightly
The price is $289 total per night from May 3 to May 4
$289 total
May 3 - May 4
Total with taxes and fees
9.6/10 Exceptional! (1,500 reviews)
Excellent hotel, would highly recommend
Reviewed on Apr 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
5/5(747 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
4.5/5(500 reviews)
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$45
per adult
92% of travellers recommend
White Villages & Ronda Day Trip from Seville
$90
per adult
94% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
$29
per adult
86% of travellers recommend
Explore a world of travel with Expedia
- Seville Hotels
- Hotels with Free Parking in Seville
- Apartments in Seville
- All-Inclusive Resorts in Seville
- Hostels in Seville
- B&B in Seville
- 5 Star Hotels in Seville
- Adults Only Resorts & in Seville
- Beach Hotels in Seville
- Boutique Hotels in Seville
- Hotels with Laundry Facilities in Seville
- 4 Star Hotels in Seville
- Gay friendly Hotels in Seville
- Melia Hotels in Seville
- Winery Hotels in Seville
- Luxury Hotels in Seville
- Hotel Wedding Venues Hotels in Seville
- Cheap Hotels in Seville
- Four Seasons Hotels in Seville
- Villas in Seville
- Hotels with Free Airport Shuttle in Seville
- Extended Stay Hotels in Seville
- Iberostar Hotels in Seville
- Family Hotels in Seville
- Romantic Hotels in Seville
- Paradores Hotels in Seville
- Condo Rentals in Seville
- Relais & Chateaux Hotels in Seville
- Historic Hotels in Seville
- Hotels with Tennis Courts in Seville
- Waterpark Hotels in Seville
- Hotels with Free Breakfast in Seville
- Resorts & Hotels with Spas in Seville
- 3 Star Hotels in Seville
- Aparthotels in Seville
- Hotels with Connecting Rooms in Seville
- Hotels with Kitchenettes in Seville
- Hotels with Early Check-in in Seville
- Hotels with Childcare in Seville
- Quiet Resorts & in Seville
- Hotels on the River in Seville
- Hotels with Air Conditioning in Seville
- Honeymoon Resorts & in Seville
- Pet-Friendly Hotels in Seville
- Guest Houses in Seville
- Golf Hotels in Seville
- Hotels with a Gym in Seville
- Wyndham Hotels in Seville
- Hotels with Balconies in Seville
- Capsule Hotels in Seville
- Casino Hotels in Seville
- Best Western Hotels in Seville
- Hotels with Restaurants in Seville
- Pensions in Seville
- Houseboats in Seville
- Hotels with a View in Seville
- Pousadas in Seville
- Vacation Homes in Seville
- Hotels with an Indoor Pool in Seville
- Car rentals near Seville
- Van Car Rentals in Seville
- Hertz Rental Cars in Seville
- Enterprise Rental Cars in Seville
- Pickup Car Rentals in Seville
- Luxury Car Rentals in Seville
- Alamo Rent A Car Rental Cars in Seville
- Thrifty Car Rental Rental Cars in Seville
- Centauro Rental Cars in Seville
- Offer Car Hire Rental Cars in Seville
- Avis Rental Cars in Seville
- Dollar Rent A Car Rental Cars in Seville
- Budget Rental Cars in Seville
- National Car Rental Rental Cars in Seville
- Minivan Car Rentals in Seville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.