Santa Cruz Vacations from $1,324

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Eurostars Regina

Hotel Eurostars Regina

3 out of 5
Historical Center
Save 100% on your flight
Price was $1,962, price is now $1,324 per person
$1,324
per person
Apr 15 - Apr 21
found 24 hours ago
Roundtrip flight included
Moline (MLI) to Seville (SVQ)
8/10 Very Good! (795 reviews)
Room and property were very clean. Bed was very comfortable. Would definitely stay again.

Reviewed on Jan 19, 2026

Hotel Exe Sevilla Palmera

Hotel Exe Sevilla Palmera

4 out of 5
Distrito Sur
Save 100% on your flight
Price was $2,436, price is now $1,578 per person
$1,578
per person
Apr 15 - Apr 21
found 24 hours ago
Roundtrip flight included
Moline (MLI) to Seville (SVQ)
8/10 Very Good! (561 reviews)
Clean room, helpful staff and great location. Value for money

Reviewed on Jan 10, 2026

Hotel Vincci Selección Unuk 5* GL

Hotel Vincci Selección Unuk 5* GL

5 out of 5
Historical Center
Save 100% on your flight
Price was $3,401, price is now $2,271 per person
$2,271
per person
Apr 22 - Apr 28
found 1 day ago
Roundtrip flight included
Moline (MLI) to Seville (SVQ)
9.6/10 Exceptional! (190 reviews)
This hotel just doesn’t feel like 5 star to me. It’s nice, but it’s not 5 star experience I am use to.

Reviewed on Jan 23, 2026

Hotel Boutique Corral del Rey by ALUZ Collection

Hotel Boutique Corral del Rey by ALUZ Collection

3 out of 5
Historical Center
Save 100% on your flight
Price was $4,110, price is now $2,784 per person
$2,784
per person
Apr 15 - Apr 21
found 16 hours ago
Roundtrip flight included
Moline (MLI) to Seville (SVQ)
9.6/10 Exceptional! (89 reviews)
Property is very quaint and walking distance to most of the sites and many restaurants. Room was very authentic. Staff was great. Breakfast is continental with yogurt, fruit, granola, coffee but you can pay for eggs and bacon. Lovely stay!

Reviewed on Jan 22, 2026

Hotel Vincci Molviedro

Hotel Vincci Molviedro

4 out of 5
Historical Center
Save 100% on your flight
Price was $2,993, price is now $2,057 per person
$2,057
per person
Apr 22 - Apr 28
found 1 day ago
Roundtrip flight included
Moline (MLI) to Seville (SVQ)
9.4/10 Exceptional! (224 reviews)
Strategic position in a quiet square. Surprising and appreciated upgrade of the room

Reviewed on Nov 28, 2025

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

8 out of top 10 points of interest in this area
4.5/5(600 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $127 total per night from Feb 1 to Feb 2
$127 total
Feb 1 - Feb 2
Total with taxes and fees
9.2/10 Wonderful! (1,004 reviews)
Really unique hotel with many courtyards. Nice spacious room with moderate size bathroom . Nice breakfast area and piano bar. Fantastic location . David from the Rock.🇨🇦🇨🇦🇨🇦 (Platinum Expedia )

Reviewed on Jan 18, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$125 nightly
The price is $138 total per night from Feb 1 to Feb 2
$138 total
Feb 1 - Feb 2
Total with taxes and fees
9.6/10 Exceptional! (1,527 reviews)
What a great 4-day stay. From check in to check out , the service, condition of the room, and spaciousness has been great. Very central location to attractions. Will not hesitate to stay again!

Reviewed on Jan 22, 2026

Hotel Fernando III
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $144 total per night from Feb 4 to Feb 5
$144 total
Feb 4 - Feb 5
Total with taxes and fees
9.4/10 Exceptional! (1,133 reviews)
The staff and the hotel were great! The staff were very friendly and helpful. Room was very clean and spacious. Definitely will be staying there again during my next visit to Sevilla. Thank you for everything!!!

Reviewed on Jan 25, 2026

Hotel Rey Alfonso X
See all 434 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Cruz

Royal Alcázar showing a church or cathedral and religious elements

Royal Alcázar of Seville

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
La Giralda which includes a castle and heritage architecture

Giralda Tower

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace which includes heritage architecture

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$38
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Ticket for Casa de la Guitarra Flamenco Show

Ticket for Casa de la Guitarra Flamenco Show

$23
per adult
88% of travellers recommend
Ticket for Casa de la Guitarra Flamenco Show
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

$55
per adult
96% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.