Santa Cruz Vacations from $1,511

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Guadalquivir

Eurostars Guadalquivir

4 out of 5
Los Remedios
Price was $2,041, price is now $1,511 per person
$1,511
per person
May 14 - May 20
found 5 hours ago
Roundtrip flight included
New York (NYC) to Seville (SVQ)
9.4/10 Exceptional! (562 reviews)
Very well located hotel

Reviewed on Mar 30, 2026

Eurostars Sevilla Boutique

Eurostars Sevilla Boutique

4 out of 5
Historical Center
Price was $2,719, price is now $1,848 per person
$1,848
per person
May 14 - May 20
found 5 hours ago
Roundtrip flight included
New York (NYC) to Seville (SVQ)
9/10 Wonderful! (506 reviews)
Perfect location. Beautiful hotel. Very Clean and the best staff.

Reviewed on Mar 24, 2026

Hotel Boutique Triana House

Hotel Boutique Triana House

3 out of 5
Triana
Price was $2,599, price is now $1,831 per person
$1,831
per person
May 14 - May 20
found 5 hours ago
Roundtrip flight included
New York (NYC) to Seville (SVQ)
9.4/10 Exceptional! (27 reviews)
I absolutely LOVED Triana House, I almost want to gate keep it! It's one of the best hotels I've ever stayed in. The interior design was STUNNING! I will definitely stay here next time I'm in Seville.

Reviewed on May 27, 2025

Becquer Hotel, Historic City Center

Becquer Hotel, Historic City Center

4 out of 5
Historical Center
Price was $2,439, price is now $1,856 per person
$1,856
per person
May 14 - May 20
found 5 hours ago
Roundtrip flight included
New York (NYC) to Seville (SVQ)
9.6/10 Exceptional! (1,006 reviews)
Very well located lovely hotel. The staff will go the extra mile for you and there are some very thoughtful touches like the welcome drink which you can choose in the bar, small complimentary gifts.

Reviewed on Mar 25, 2026

Genteel Home San Fernando

Genteel Home San Fernando

4 out of 5
Historical Center
Save 100% on your flight
Price was $4,199, price is now $3,200 per person
$3,200
per person
May 14 - May 20
found 5 hours ago
Roundtrip flight included
New York (NYC) to Seville (SVQ)
No reviews

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$215 nightly
The price is $237 total per night from Apr 6 to Apr 7
$237 total
Apr 6 - Apr 7
Total with taxes and fees
9.2/10 Wonderful! (1,005 reviews)
Staying at this hotel is an adventure in history. To think that we walked the same paths as Christoper Columbus and crew was humbling and gave us a sense of Sevilla’s role in bridging the new world with the old. The hotel is centrally located in the Santa Cruz neighborhood close to all of the must ...

Reviewed on Apr 2, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$231 nightly
The price is $254 total per night from Apr 6 to Apr 7
$254 total
Apr 6 - Apr 7
Total with taxes and fees
9.6/10 Exceptional! (1,484 reviews)
We had a wonderful four-night stay at Hotel Fernando III during our recent trip that happened to coincide with Semana Santa 2026. It was our first trip to Serville. The location of this hotel could not have been better for our planned itinerary. The staff were warm, helpful and informative. The breakfast ...

Reviewed on Apr 2, 2026

Hotel Fernando III
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$664 nightly
The price is $730 total per night from Apr 6 to Apr 7
$730 total
Apr 6 - Apr 7
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Staff

Reviewed on Feb 27, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
See all 436 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Alone in the Alcazar: Exclusive Early Access Tour

Alone in the Alcazar: Exclusive Early Access Guided Tour

$119
per adult
100% of travellers recommend
Alone in the Alcazar: Exclusive Early Access Guided Tour
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

$29
per adult
86% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$79
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.