Santa Cruz Vacations from $1,057

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Guadalquivir

Eurostars Guadalquivir

4 out of 5
Los Remedios
Price was $1,427, price is now $1,057 per person
$1,057
per person
Apr 26 - May 2
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Seville (SVQ)
9.4/10 Exceptional! (562 reviews)
Desayuno variado. Me quedan a deber en la calidad del café

Reviewed on Mar 19, 2026

Eurostars Sevilla Boutique

Eurostars Sevilla Boutique

4 out of 5
Historical Center
Save 100% on your flight
Price was $2,005, price is now $1,412 per person
$1,412
per person
Apr 26 - May 2
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Seville (SVQ)
9/10 Wonderful! (506 reviews)
We very much enjoyed our stay here. Excellent location. I would recommend.

Reviewed on Jan 17, 2026

Hotel Exe Isla Cartuja

Hotel Exe Isla Cartuja

4 out of 5
Triana
Price was $1,682, price is now $1,290 per person
$1,290
per person
Apr 26 - May 2
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Seville (SVQ)
7.6/10 Good! (629 reviews)
Hotel is quite nice. Would have liked a kettle/coffee machine in our room given the 4 star rating. I also needed an iron but none was available in the room. It is outside the city but we knew that and we had a car for travelling. Free parking is a bonus!

Reviewed on Aug 14, 2025

Hotel Exe Sevilla Palmera

Hotel Exe Sevilla Palmera

4 out of 5
Distrito Sur
Price was $1,579, price is now $1,227 per person
$1,227
per person
Apr 26 - May 2
found 1 day ago
Roundtrip non-stop flight included
Chicago (CHI) to Seville (SVQ)
8/10 Very Good! (576 reviews)
The room was in good condition. The staff was very nice and kind and helped us out a lot and gave us slippers are an iron when we needed. They even called a taxi for us to the airport. The only thing I would take away points for is the fact that there was no ventilation for a four star hotel and also the shower door does not close. I personally don’t prefer that. Other than that, it was a good stay.

Reviewed on Feb 21, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

8 out of top 10 points of interest in this area
4.5/5(604 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $234 total per night from Mar 22 to Mar 23
$234 total
Mar 22 - Mar 23
Total with taxes and fees
9.2/10 Wonderful! (1,009 reviews)
Great area, the hotel seems to be made out of the old casas with tunnel connecting them all and a few patio and small quaint gardens in between them. The staff was very eager to help and nice. Breakfast has a lot of options and very good.

Reviewed on Mar 18, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
$222 nightly
The price is $245 total per night from Mar 27 to Mar 28
$245 total
Mar 27 - Mar 28
Total with taxes and fees
9.6/10 Exceptional! (1,486 reviews)
Staff were very friendly and it was really lovely that they sorted some fizz for my friend's birthday. Roof top terrace was really nice and breakfast had lots of choice. Only downsides were the room only had a very small internal window which made it feel a bit claustrophobic. Also a shame for the ...

Reviewed on Mar 17, 2026

Hotel Fernando III
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$539 nightly
The price is $593 total per night from Apr 6 to Apr 7
$593 total
Apr 6 - Apr 7
Total with taxes and fees
9.4/10 Exceptional! (1,000 reviews)
Staff

Reviewed on Feb 27, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
See all 432 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
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Kid Friendly Vacations

Discover the most popular places to visit in Santa Cruz

Royal Alcázar showing a church or cathedral and religious elements

Royal Alcázar of Seville

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
La Giralda which includes a castle and heritage architecture

Giralda Tower

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace which includes heritage architecture

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$39
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$81
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

$58
per adult
96% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.