Santa Cruz Vacations from $1,417

Book a Hotel + Flight or Car together to unlock savings

Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Madrid Sevilla

Hotel Madrid Sevilla

1 out of 5
Historical Center
Price was $2,095, price is now $1,417 per person
$1,417
per person
Jul 9 - Jul 11
found 13 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Seville (SVQ)
8.6/10 Excellent! (1,000 reviews)
Really nice staff, the room itself was really good - perfect for a few nights. Clean and in a good area - great for exploring the city.

Reviewed on Feb 21, 2026

Welldone Quality - Crystal Pool

Welldone Quality - Crystal Pool

1 out of 5
Historical Center
Price was $2,140, price is now $1,434 per person
$1,434
per person
Jul 9 - Jul 11
found 13 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Seville (SVQ)
9.2/10 Wonderful! (394 reviews)
Excelente ubicación y recepción del personal, el proceso de check-in muy fluido.

Reviewed on Jan 26, 2026

Welldone Sierpes Boutique

Welldone Sierpes Boutique

2 out of 5
Historical Center
Price was $2,123, price is now $1,424 per person
$1,424
per person
Jul 9 - Jul 11
found 13 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Seville (SVQ)
9.4/10 Exceptional! (595 reviews)
Great location, property was pretty hard to find and not always staffed. Everything was nice but felt more like an Airbnb.

Reviewed on Apr 2, 2026

Hotel Colón Gran Meliá

Hotel Colón Gran Meliá

5 out of 5
Historical Center
Price was $2,407, price is now $1,615 per person
$1,615
per person
Jul 9 - Jul 11
found 13 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Seville (SVQ)
9.6/10 Exceptional! (1,000 reviews)
beautiful views from the rooftop pool

Reviewed on Mar 25, 2026

Hotel Ribera de Triana - REOPENING!

Hotel Ribera de Triana - REOPENING!

4 out of 5
Triana
Price was $2,124, price is now $1,431 per person
$1,431
per person
Jul 9 - Jul 11
found 13 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Seville (SVQ)
8.8/10 Excellent! (936 reviews)
Good Location, nice room with river view. Good breakfast.

Reviewed on Apr 9, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
$216 nightly
The price is $238 total per night from Apr 13 to Apr 14
$238 total
Apr 13 - Apr 14
Total with taxes and fees
9.2/10 Wonderful! (1,014 reviews)
Really unique and beautiful hotel in a great location for exploring the city.

Reviewed on Apr 12, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
$757 nightly
The price is $833 total per night from May 5 to May 6
$833 total
May 5 - May 6
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Simply amazing property. Amazing service

Reviewed on Apr 8, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
$264 nightly
The price is $290 total per night from Apr 13 to Apr 14
$290 total
Apr 13 - Apr 14
Total with taxes and fees
9.6/10 Exceptional! (1,492 reviews)
The breakfast was fine

Reviewed on Apr 5, 2026

Hotel Fernando III
See all 436 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$45
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

$29
per adult
86% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$79
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
See all activities in Seville

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.