Santa Cruz Vacations from $1,397
Book a Hotel + Flight or Car together to unlock savings
Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Eurostars Al-Ándalus Palace
Bellavista-La Palmera
Price was $1,752, price is now $1,397 per person
$1,397
per person
Jun 9 - Jun 15
found 24 hours ago
Roundtrip flight included
Boston (BOS) to Seville (SVQ)
8.6/10 Excellent! (1,183 reviews)
Agree with other reviews that hotel should not be rated four stars. Overall, it was 15 minutes cab ride to center. Staff was mostly supportive. It is outdated and needs renovation especially bathrooms.
Reviewed on Apr 11, 2026
Eurostars Sevilla Boutique
Historical Center
Price was $2,420, price is now $1,739 per person
$1,739
per person
Jun 9 - Jun 15
found 24 hours ago
Roundtrip flight included
Boston (BOS) to Seville (SVQ)
9/10 Wonderful! (507 reviews)
Perfect location. Beautiful hotel. Very Clean and the best staff.
Reviewed on Mar 24, 2026
Hotel Lobby
Historical Center
Price was $2,027, price is now $1,789 per person
$1,789
per person
Jun 19 - Jun 22
found 1 day ago
Roundtrip flight included
Boston (BOS) to Seville (SVQ)
9.6/10 Exceptional! (503 reviews)
Excellent hotel which is situated in a great location for walking around the city. From start to finish, all the staff were excellent and efficient. The room was a good size, clean, and had everything we needed. The breakfast was brilliant, with some tasty options and again the staff were fantastic. I highly recommend this hotel for anyone considering to visit Sevilla. We will definitely stay at this hotel again if we visit Sevilla again!
Reviewed on Apr 10, 2026
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
7 out of top 10 points of interest in this area
4.5/5(606 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$201 nightly
The price is $221 total per night from May 17 to May 18
$221 total
May 17 - May 18
Total with taxes and fees
9.2/10 Wonderful! (1,018 reviews)
This place is an absolute gem. Friendly staff, delicious breakfast, walkable to all sites in the city. Highly recommend
Reviewed on Apr 15, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
$718 nightly
The price is $789 total per night from Apr 27 to Apr 28
$789 total
Apr 27 - Apr 28
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Simply amazing property. Amazing service
Reviewed on Apr 8, 2026
Hotel Fernando III
San Jose 21 Seville Seville
$255 nightly
The price is $280 total per night from May 4 to May 5
$280 total
May 4 - May 5
Total with taxes and fees
9.6/10 Exceptional! (1,503 reviews)
Once you arrive they make it easy!! They were very accommodating with checking in and out and taking care of the car. Location is perfect!
Reviewed on Apr 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
5/5(747 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
4.5/5(500 reviews)
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$45
per adult
92% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
$29
per adult
86% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
$79
per adult
100% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.