Santa Cruz Vacations from $540
Book a Hotel + Flight or Car together to unlock savings
Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Only YOU Hotel Sevilla
San Pablo-Santa Justa
Price was $1,411, price is now $1,077 per person
$1,077
per person
Feb 15 - Feb 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Seville (SVQ)
9.8/10 Exceptional! (555 reviews)
What a good hotel, wish we had been staying for longer than the one night.
Reviewed on Dec 3, 2025
Petit Palace Marqués Santa Ana
Historical Center
Price was $1,185, price is now $997 per person
$997
per person
Feb 15 - Feb 20
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Seville (SVQ)
9/10 Wonderful! (1,001 reviews)
Really helpful and friendly reception staff. Room was spotless. Perfect location.
Reviewed on Nov 8, 2025
Eurostars Sevilla Boutique
Historical Center
Price was $793, price is now $597 per person
$597
per person
Jan 31 - Feb 3
found 19 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Seville (SVQ)
9/10 Wonderful! (481 reviews)
Room was spotless, staff was courteous and location was perfect!
Reviewed on Nov 17, 2025
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
8 out of top 10 points of interest in this area
4.5/5(600 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$114 nightly
The price is $125 total per night from Dec 9 to Dec 10
$125 total
Dec 9 - Dec 10
Total with taxes and fees
9.2/10 Wonderful! (1,014 reviews)
The property had real historic character - in a great location with helpful and friendly staff
Reviewed on Dec 2, 2025
Hotel Rey Alfonso X
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $134 total per night from Dec 9 to Dec 10
$134 total
Dec 9 - Dec 10
Total with taxes and fees
9.4/10 Exceptional! (1,109 reviews)
Very clean room and crib provided
Reviewed on Dec 4, 2025
Hotel Fernando III
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $123 total per night from Dec 9 to Dec 10
$123 total
Dec 9 - Dec 10
Total with taxes and fees
9.6/10 Exceptional! (1,529 reviews)
Hotel in a great location. Pool terrace a huge bonus. Staff very efficient.
Reviewed on Nov 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
5/5(735 reviews)
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
4.5/5(496 reviews)
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$38
per adult
92% of travellers recommend
Seville Guided Tour with Fast-Track Entry to Alcázar, Cathedral & Giralda
$88
per adult
84% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.