Santa Cruz Vacations from $953

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Exe Sevilla Palmera

Hotel Exe Sevilla Palmera

4 out of 5
Distrito Sur
Save 100% on your flight
Price was $1,454, price is now $953 per person
$953
per person
Apr 22 - Apr 29
found 1 day ago
Roundtrip flight included
Casablanca (CMN) to Seville (SVQ)
8/10 Very Good! (573 reviews)
The room was in good condition. The staff was very nice and kind and helped us out a lot and gave us slippers are an iron when we needed. They even called a taxi for us to the airport. The only thing I would take away points for is the fact that there was no ventilation for a four star hotel and also the shower door does not close. I personally don’t prefer that. Other than that, it was a good stay.

Reviewed on Feb 21, 2026

Genteel Home Cabildo V

Genteel Home Cabildo V

3.5 out of 5
Historical Center
Save 100% on your flight
Price was $3,597, price is now $2,749 per person
$2,749
per person
Apr 22 - Apr 29
found 1 day ago
Roundtrip flight included
Casablanca (CMN) to Seville (SVQ)
No reviews
Eurostars Sevilla Boutique

Eurostars Sevilla Boutique

4 out of 5
Historical Center
Save 100% on your flight
Price was $2,409, price is now $1,549 per person
$1,549
per person
May 14 - May 20
found 1 day ago
Roundtrip flight included
New York (JFK) to Seville (SVQ)
9/10 Wonderful! (504 reviews)
We very much enjoyed our stay here. Excellent location. I would recommend.

Reviewed on Jan 17, 2026

Exe Sevilla Macarena

Exe Sevilla Macarena

4 out of 5
Macarena
Save 100% on your flight
Price was $1,964, price is now $1,318 per person
$1,318
per person
Apr 21 - Apr 27
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
8/10 Very Good! (998 reviews)
Room didnt smell good, would be nice if they have coffee in the room or vendo machine for hot bevereges in the lobby. Happy that they have vendo machine for cold drinks. Asked for a wakeup call but never got it. You can hear the voices and snoring of the people next door.

Reviewed on Feb 13, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(600 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
$213 nightly
The price is $235 total per night from Mar 15 to Mar 16
$235 total
Mar 15 - Mar 16
Total with taxes and fees
9.6/10 Exceptional! (1,512 reviews)
Fantastic location. Very clean and modern rooms. Breakfast buffet is very complete with excellent choices.

Reviewed on Mar 11, 2026

Hotel Fernando III
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$167 nightly
The price is $184 total per night from Mar 15 to Mar 16
$184 total
Mar 15 - Mar 16
Total with taxes and fees
9.2/10 Wonderful! (1,022 reviews)
We stayed here for two whole weeks. The property is unique and beautiful.

Reviewed on Mar 11, 2026

Las Casas de la Judería, Sevilla Historic City Center
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Fully refundableReserve now, pay when you stay
$224 nightly
The price is $247 total per night from Mar 22 to Mar 23
$247 total
Mar 22 - Mar 23
Total with taxes and fees
9.6/10 Exceptional! (1,147 reviews)
Hotel is comfortable, clean and central. Staff are very accommodating and extremely helpful.

Reviewed on Mar 9, 2026

Hotel Rey Alfonso X
See all 436 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Cruz

Royal Alcázar showing a church or cathedral and religious elements

Royal Alcázar of Seville

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
La Giralda which includes a castle and heritage architecture

Giralda Tower

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace which includes heritage architecture

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$39
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
Sevilla Food Tour: Tapas, Wine, History & Traditions

Sevilla Food Tour: Tapas, Wine, History & Traditions

$81
per adult
100% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas

$58
per adult
96% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.