Santa Cruz Vacations from $405
Book a Hotel + Flight or Car together to unlock savings
Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
The Latest Santa Cruz Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hotel Exe Isla Cartuja
Triana
Price was $551, price is now $405 per person
$405
per person
Apr 22 - Apr 24
found 1 day ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
7.6/10 Good! (629 reviews)
Hotel is quite nice. Would have liked a kettle/coffee machine in our room given the 4 star rating. I also needed an iron but none was available in the room. It is outside the city but we knew that and we had a car for travelling. Free parking is a bonus!
Reviewed on Aug 14, 2025
Apartamentos Metrópolis Sevilla
Historical Center
Save 100% on your flight
Price was $683, price is now $458 per person
$458
per person
Apr 22 - Apr 24
found 4 hours ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
8.8/10 Excellent! (179 reviews)
The location of this apartment is perfect - close to all touristic locations and pretty decent dining options etc.
Reviewed on Dec 23, 2025
Eurostars Sevilla Boutique
Historical Center
Save 100% on your flight
Price was $977, price is now $660 per person
$660
per person
Apr 22 - Apr 24
found 1 day ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
9/10 Wonderful! (506 reviews)
We very much enjoyed our stay here. Excellent location. I would recommend.
Reviewed on Jan 17, 2026
Eurostars Al-Ándalus Palace
Bellavista-La Palmera
Price was $698, price is now $501 per person
$501
per person
Apr 22 - Apr 24
found 1 day ago
Roundtrip flight included
Barcelona (BCN) to Seville (SVQ)
8.6/10 Excellent! (1,170 reviews)
Clean rooms, amenities, nice property. Not very helpful staff at reception though.
Reviewed on Feb 24, 2026
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
8 out of top 10 points of interest in this area
4.5/5(600 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Judería, Sevilla Historic City Center
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
$192 nightly
The price is $211 total per night from Mar 22 to Mar 23
$211 total
Mar 22 - Mar 23
Total with taxes and fees
9.2/10 Wonderful! (1,006 reviews)
This hotel is a gem. It's like they took old town and stuffed it into hotel. Just take a look at the pictures and you can see it's pretty magical. My room originally was too small for my liking (it literally was only as big as a foot and a half around the bed) but they happily switched me to a more ...
Reviewed on Mar 16, 2026
Hotel Fernando III
San Jose 21 Seville Seville
$218 nightly
The price is $240 total per night from Mar 27 to Mar 28
$240 total
Mar 27 - Mar 28
Total with taxes and fees
9.6/10 Exceptional! (1,492 reviews)
Lovely hotel in a perfect location. Professional, courteous, friendly staff throughout. We had selected the cheapest room available which turned out to be spacious, clean, very well maintained/decorated. Included safe, hairdryer, mini fridge, daily bottles of water and toiletries. Complimentary bottle ...
Reviewed on Mar 16, 2026
Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
$628 nightly
The price is $691 total per night from Apr 14 to Apr 15
$691 total
Apr 14 - Apr 15
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
Staff
Reviewed on Feb 27, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$39
per adult
92% of travellers recommend
Sevilla Food Tour: Tapas, Wine, History & Traditions
$81
per adult
100% of travellers recommend
Flamenco Show at Tablao El Arenal with Drink and Optional Dinner or Tapas
$58
per adult
96% of travellers recommend
Explore a world of travel with Expedia
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.