Santa Cruz Vacations
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Your Santa Cruz Vacation
Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.
Where to stay in Santa Cruz
Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center
7 out of top 10 points of interest in this area
4.5/5(600 area reviews)
Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.
Santa Cruz Hotel Deals
Las Casas de la Juderia
Calle Santa Maria La Blanca 5, Seville, Seville
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $187 total per night from Nov 2 to Nov 3
$187 total
Nov 2 - Nov 3
Total with taxes and fees
9.2/10 Wonderful! (1,024 reviews)
"Amazing hotel complex. Beautiful rooms. In the centre of old Sevilla."
Reviewed on Sep 25, 2025
Hotel Rey Alfonso X
Calle Ximenez De Enciso, 35, Seville, Seville
$179 nightly
The price is $197 total per night from Nov 5 to Nov 6
$197 total
Nov 5 - Nov 6
Total with taxes and fees
9.4/10 Exceptional! (1,057 reviews)
"I love the facilities at Alfonso X. I wish the terrace had dinning options too. The staff as always 10/10."
Reviewed on Oct 5, 2025
Hotel Murillo
Calle Lope de Rueda, 7-9, Seville, Seville
Fully refundable
$103 nightly
The price is $113 total per night from Oct 30 to Oct 31
$113 total
Oct 30 - Oct 31
Total with taxes and fees
8.6/10 Excellent! (1,000 reviews)
Excellent location, great staff, basic bedroom
"The lobby/reception area is beautiful, and I was checked in by a wonderfully friendly member of staff. My room is what can best be described as dated. It was clean but things like the bed not having a headboard or the curtains not being made from blackout material brings down the overall feel of ..."
Reviewed on Sep 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Royal Alcázar of Seville
Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.
Giralda Tower
Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.
San Telmo Palace
Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.
Things to do
Cathedral & Alcázar of Seville Guided Tour Combo
$39
per adult
92% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
$30
per adult
82% of travellers recommend
Ticket for Casa de la Guitarra Flamenco Show
$24
per adult
88% of travellers recommend
Explore a world of travel with Expedia
Explore a world of travel with Expedia
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.