Title: Visit Santa Cruz: 2026 Travel Guide for Santa Cruz, Trujillo | Expedia.com

[Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels.d836916946927771648.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz](https://expedia.com/Santa-Cruz-Vacation-Rentals.d836916946927771648.Travel-Guide-VacationRentals)[Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d836916946927771648.Travel-Guide-Flights)[Car Rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d836916946927771648.Car-Rental-Guide)[Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d836916946927771648.Destination-Travel-Guides)

# Santa Cruz

## Travel Guide

## Visit Santa Cruz

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## 

The Annual Vacation Sale

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- Santa Cruz Hotel Deals

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Guadalupe Resort

Avenida Principal La Puerta, La Puerta URD

Stay at this hotel in La Puerta. Enjoy tennis courts.

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677566&PinnedHotelID=14677566&HadPinnedHotel=true&regionId=836916946927771648)

[](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677566&PinnedHotelID=14677566&HadPinnedHotel=true&regionId=836916946927771648)

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Conjunto Turistico Vacacional Cordillera

Final Calle 4 Municipio Valera, La Puerta URD

Stay at this hotel in La Puerta. Enjoy a bar/lounge.

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677431&PinnedHotelID=14677431&HadPinnedHotel=true&regionId=836916946927771648)

[](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677431&PinnedHotelID=14677431&HadPinnedHotel=true&regionId=836916946927771648)

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Hotel La Sierra Santo Domingo

Avenida Principal de Santo Domingo DE Santo Domingo RIM

Stay at this hotel in Santa Polonia.

[Get rates](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677459&PinnedHotelID=14677459&HadPinnedHotel=true&regionId=836916946927771648)

[](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=14677459&PinnedHotelID=14677459&HadPinnedHotel=true&regionId=836916946927771648)

[See all 4 properties in Trujillo](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F14%2F2026&endDate=2%2F15%2F2026&regionId=6278545)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Santa Cruz hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2026-02-13&endDate=2026-02-14)[Feb 13 - Feb 14](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2026-02-13&endDate=2026-02-14)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2026-02-14&endDate=2026-02-15)[Feb 14 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2026-02-14&endDate=2026-02-15)

[This weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)[Feb 13 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=836916946927771648&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)

- Cities near Santa Cruz

[Carache](https://expedia.com/Carache.dx836916941108178944)

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