South America Vacations & Trips

Book a Hotel + Flight or Car together to unlock savings

Choose one or more items to build your trip:

Save up to 30% when you add a hotel to your flight as an Expedia member

Enjoy flexibility with our Book now Pay later option & fully refundable rates on most hotels

Customize your vacation with ease all in one place

Top destinations in South America

South America Flight and Hotel Deals

El Polo Apart Hotel & Suites
Hyatt Centric San Isidro Lima
NH Collection Bogotá Teleport Royal
DoubleTree by Hilton Bogota Salitre AR
NH Collection Bogotá Hacienda Royal

South America Hotel Deals

Almacruz Hotel y Centro de Convenciones
Almacruz Hotel y Centro de Convenciones
4 out of 5
San Antonio 65, Santiago, Region Metropolitana, 8320263
Fully refundableReserve now, pay when you stay
The price is $99 per night from Feb 18 to Feb 19
$99
per night
Feb 18 - Feb 19
4/5 Very Good! (330 reviews)
"The property offers a great breakfast that is better than many much more expensive hotels. The rooms are good for a 4 stars hotel. Location is in city center; which is unsafe when it gets dark. That was the only inconvenience, since it is not recommended to walk around after darkness"

Reviewed on Feb 3, 2023

Almacruz Hotel y Centro de Convenciones
Rochester Classic
Rochester Classic
3.5 out of 5
Esmeralda 542, Buenos Aires, Capital Federal, 1007
Fully refundableReserve now, pay when you stay
The price is $102 per night from Feb 27 to Feb 28
$102
per night
Feb 27 - Feb 28
3.7/5 Good! (432 reviews)
"Convenient location to explore downtown on foot or by public transport. I arrived around 1 am and checked in in no time. wifi signal was adequate."

Reviewed on Jan 17, 2022

Rochester Classic
Regal Pacific Buenos Aires
Regal Pacific Buenos Aires
4.5 out of 5
25 De Mayo, 764, Buenos Aires, Capital Federal, BPN1002
Fully refundableReserve now, pay when you stay
The price is $134 per night from Feb 25 to Feb 26
$134
per night
Feb 25 - Feb 26
4.4/5 Excellent! (1,012 reviews)
"Staff were really friendly, the young lady on the desk was extremely helpful. No complaints, decent breakfast options. Wi-Fi was good."

Reviewed on Jan 26, 2023

Regal Pacific Buenos Aires
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a South America vacation package cost?
Browse and book everything in one place with our South America vacation packages, which start from only $583. Choose the flights and hotels that suit your plans. Then, add on a few sightseeing tours for an unforgettable adventure.
If I'm not able to travel, can I cancel my South America vacation package?
It’s good to know that you can cancel your South America booking if your plans have changed. Whether you’ll be charged a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change your booking for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
How do I get a cheap travel package to South America?
Imagine all the amazing things you could do in South America with a spare $583*. If you combine your flights, hotels and other bookings into a package, that’s the amount you could save! You have a wealth of choice when you book with Expedia. In fact, you can take your pick of more than 550 air carriers and 1,000,000 hotel options worldwide. Whether you’re taking time out with the whole family or embarking on a solo adventure, exploring South America is better with a deal.
When is the best time of year to visit South America?
If keeping expenses to a minimum is a priority, is the best time to escape to South America. is usually the priciest month, so you’ll need a bigger travel budget if you visit then. are the peak season months and when this destination is often at its most exciting. Clear space in your calendar for if you’d prefer a quieter escape.
How far in advance should I book my South America vacation?
It’s hard to pick the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available to compare up to a year in advance. If you’re booking at the last minute, don’t despair. Cheap prices appear from time to time just weeks before departure dates.
What does an Expedia South America travel package include?
With Expedia, you can choose any combination of car rentals, flights and hotels to create your perfect South America travel package. Once you’ve made your booking, you can add on the fun stuff like sightseeing tours and activities. Don’t forget, the more you bundle, the greater the savings!
What should I know before booking a South America travel package?
A Expedia travel package can be customized for your budget and is a great way to stretch your dollars further. How little or much you include is your call. Hotels, rental cars and flights — decide on a combination that works with your plans.
Does Expedia offer Book Now, Pay Later South America vacation packages?
If the reason for your travel has arisen unexpectedly, Expedia can help to reduce any financial strain. Working with online lender Affirm, we offer a Book Now, Pay Later solution for all package bookings. It’s easy to set up a payment schedule for your journey that works for you.
Can I choose my airline with a South America Expedia vacation package?
Yes, of course. We have more than 550 partner airlines worldwide, so choose the carrier that suits your budget and travel needs.
Can I travel to South America right now?
For all the information you need about visiting South America, head to our Covid-19 Travel Advisor. Covering travel restrictions, quarantine policies and more, Expedia will help make your trip planning as stress-free as possible.