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Visitors to this part of Costa Caribe share space with approximately 950,000 residents.
The national capital of Bogota is situated 410 miles south of Cartagena, while Santa Catalina lies 25 miles to the northeast.
If you want to get stuck straight into the most famed sights, San Felipe de Barajas Castle and the Puerta del Reloj should be right at the top of your list.
Rosario Islands Oceanarium is an undersea excursion for the entire family.
After some late-night thrills? Try your luck at the Rio Cartagena Casino, a fun-filled venue where the action never stops.
When the weather is fine, pack some lunch and find a shady corner at one of the area's pleasant green spaces, such as Cerro de La Popa or Centenary Park. Parque de La Marina and El Totumo Mud Volcano are two more nice places to while away a lazy day over a good book.
If you have trouble separating the words "vacation" and "beach" then this place is for you. There's plenty of scenic coastline here to satisfy even the most amphibious travelers. Marbella Beach and Bocagrande Beach should be at the top of your list. La Boquilla Beach and Isla Grande Beach are also recommended.
Nature enthusiasts often make their way to Corales del Rosario National Park and Islas del Rosario for a break.
See the world from a new perspective with a trip to one of the area's intriguing cultural institutions. The Naval Museum Cartagena and Simon Bolivar House and Museum offer a range of collections that are sure to capture your attention. Another two to look at are the Cartagena Museum of Modern Art and the Caribbean Naval Museum.
Visitors interested in natural science and history should spend some time exploring the specimens and objects at the Museo del Oro y Arqueología.
Enter a world of art ingenuity at the Cano Gallery.
Travel back to days gone by and uncover the secrets of the past at the Palacio de la Inquisición or the Casa de Rafael Núñez. The Palacio de la Inquisicion and the Colonial Museum are also prominent options.
Wander back through the ages with a visit to the Clock Tower or the Las Bovedas, just two of the historical sites here. When it comes to bygone times, the stories are countless. The University of Cartagena and Jardines de Paz are also great places to check out.
San Fernando Fort and Fuerte Pastelillo are old fortifications which stand as testament to Cartagena's military history. The age-old walls of Fuerte de San Sebastián del Pastelillo also have plenty of stories to tell.
Inquisition Palace is an impressive time capsule, boasting some of the best architecture and design in the region.
The region's spiritual side can be experienced at San Pedro Claver Church and Convent and San Francisco Church. If you'd like to explore some more religious sites, check for tours at Cartagena Cathedral and Santo Domingo Church and Monastery.
Whether you are traveling through Cartagena for work or for pleasure, you're not going to regret stopping by the Ciudad Movil Cultural Center or the Fine Arts.
The Expedia Cartagena hotels page shows no less than 213 luxurious and low-budget accommodation options, so you shouldn't have any problems finding a great place in this popular destination.
Often recommended examples of slightly more upscale short or long stay accommodation options in Cartagena are the Casa Pombo, Calle del Arzobispado 34 -14, and the Tcherassi Hotel & Spa, Calle del Sargento Mayor 6-21. The Hotel Costa del Sol, at Bocagrande Crra 1a No.9 18, Novena esq, and the Casa Mary, at Calle Del Guerrero 29-89 Getsemani are two lower priced offerings that you may find worth investigating if you're traveling on a tight budget.
One of the most popular aspects of any stay in Cartagena is San Felipe de Barajas Castle. If you'd prefer to stay nearby the famed attraction, the Sofitel Legend Santa Clara Cartagena and the Armeria Real Luxury Hotel & Spa by Faranda Boutique are both great options.
The world is packed with adventure, and there are heaps of epic experiences to be had when we grab our bags and go on vacation.
Kick-start your trip to Cartagena by trying one or two of these activities:
Got a little time on your side? Head to our Cartagena things to do page for a full range of options.
*Savings based on all vacation package bookings with Flight + Hotel on Expedia.com from January through December 2017, as compared to price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages. For Free Flight or 100% Off Flight deals, package savings is greater than or equal to the current cost of one component, when both are priced separately.