South America Vacations & Trips from $428

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Top destinations in South America

Bank of Brazil Cultural Center showing heritage architecture and street scenes as well as a large group of people
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Sao Paulo

Sao Paulo

The Latest South America Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Windsor House Inn By GEH Suites

Hotel Windsor House Inn By GEH Suites

4.5 out of 5
Chicó
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip non-stop flight included
San Juan (SJU) to Bogotá (BOG)
8.6/10 Excellent! (153 reviews)
Great stay for my dad!

Reviewed on May 26, 2025

Hotel Plaza Suites

Hotel Plaza Suites

3.5 out of 5
Usaquén
Save 100% on your flight
per person
Aug 22 - Sep 3
found 1 day ago
Roundtrip flight included
Miami (MIA) to Bogotá (BOG)
9.6/10 Exceptional! (117 reviews)
wanted to take a moment to express my appreciation for my recent stay at hotel plaza suits. This being my second visit, I was once again impressed by how well-maintained the rooms are. The staff members are incredibly friendly and accommodating, which adds to the welcoming atmosphere of the hotel. Additionally, the location is perfect—safe and convenient for all my needs while visiting. Thank you for providing such a wonderful experience. I look forward to staying with you again in the future.

Reviewed on May 17, 2025

Ochenta Diez by Wynwood House

Ochenta Diez by Wynwood House

2.5 out of 5
Zona T
Save 100% on your flight
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip non-stop flight included
San Juan (SJU) to Bogotá (BOG)
No reviews
Petit Palace Apart Hotel Suites

Petit Palace Apart Hotel Suites

3.5 out of 5
Miraflores
per person
Sep 10 - Sep 18
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Lima (LIM)
8.6/10 Excellent! (434 reviews)
Property is stratgicallly located around all shops and restsurants

Reviewed on Jun 1, 2025

Swissôtel Lima

Swissôtel Lima

5 out of 5
San Isidro
per person
Sep 10 - Sep 18
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Lima (LIM)
9.4/10 Exceptional! (644 reviews)
Beautiful hotel with a wonderful breakfast buffet. The rooms are very large and it was in a good location walkable to a ruin

Reviewed on Jul 5, 2025

Best Places to Vacation in South America

1. Experience Amazon Jungle with a travel package

The Amazon Jungle is a paradise for nature lovers and adventure seekers. With its vast rainforests, meandering rivers, and diverse wildlife, it offers a unique and immersive experience for families. You can explore the jungle on a thrilling boat ride or canoeing expedition, discovering hidden gems along the way. The secluded sand beaches provide a perfect spot for relaxation and picnics. For the more adventurous, there are opportunities for rock climbing and exploring the dense forests. A popular activity is taking a cruise or an ocean cruise, allowing you to witness the beauty of the Amazon in all its glory.

  • The peak season is from August to October
  • The off-peak season is from December to February

2. Plan your dream getaway to Bolivian Yungas

The Bolivian Yungas region offers a unique and diverse atmosphere for travelers seeking a scenic vacation. With its geographic affinities, visitors can enjoy a range of experiences, from exploring quaint cafes and immersing themselves in the local culture and archaeology, to venturing into the picturesque countryside and lush jungle. For adventure enthusiasts, the hilly terrain and desert landscapes provide opportunities for activities like snowboarding. Additionally, the region is known for its trendy spots, making it a perfect destination for those looking for a mix of relaxation and excitement.

3. Explore Pampas with a vacation package

Pampas offers a diverse and vibrant atmosphere for outdoor vacation experiences. Whether you enjoy cafes, dining, entertainment, dancing, shopping, tours, sightseeing, live music, walking, or museums, Pampas has something for everyone. With its geographical affinities, you can explore the local culture and immerse yourself in the lively atmosphere. From quaint cafes to bustling markets, Pampas seamlessly blends traditional charm with modern amenities. Whether you want to relax and enjoy live music or embark on a sightseeing adventure, Pampas promises an unforgettable outdoor vacation experience.

4. Book your ideal Andes with a vacation package

Andes offers a unique and affordable vacation experience for travelers. The local atmosphere is vibrant and welcoming, with a rich cultural heritage. Visitors can explore the stunning natural landscapes, such as the majestic Andes Mountains and picturesque valleys. The region is known for its adventurous activities like hiking, mountain biking, and horseback riding. Additionally, travelers can immerse themselves in the local culture by visiting traditional markets, sampling delicious local cuisine, and enjoying traditional music and dance performances. With its affordable prices and diverse attractions, a vacation in Andes promises an unforgettable and budget-friendly experience.

Find the Best South America Vacation Packages

Best months to visit South America

Looking for the best time to visit South America? Our table will help you. South America boasts a year-round average temperature of 57.5°F, reaching a peak of 72.0°F in February, its warmest month, and dropping to an average low of 42.1°F in July, the coolest month. The annual rainfall averages 88.1mm, with December experiencing the heaviest showers, while August is the driest month.

Monthcalendar iconTemperature (Fahrenheit)temperature iconRainfallrain iconCloud coveragecloud icon
January70.5Light RainMostly Sunny
February72.0Light RainMostly Sunny
March69.1Light RainMostly Sunny
April49.1Light RainMostly Sunny
May48.9Light RainMostly Sunny
June50.4No Rain (Dry)Mostly Sunny
July42.1No Rain (Dry)Mostly Sunny
August62.1No Rain (Dry)Sunny
September53.8Light RainMostly Sunny
October50.4Light RainMostly Sunny
November51.1Light RainMostly Sunny
December70.2Light RainMostly Sunny

How to save money on a vacation to South America

  • Combine your flights with hotels or car rentals to save money, especially in popular destinations like Rio de Janeiro or Machu Picchu.
  • Take advantage of Expedia's OneKey program to collect points and save money on future trips to South America.
  • Utilize the helpful search filters on Expedia to find the perfect accommodation within your price range, whether it's a luxury hotel or a budget-friendly hostel.
  • Consider traveling during the low season in South America, which varies by destination, for the most budget-friendly options.
  • Use the search filter for price limits on Expedia to find a package deal that suits your budget.
  • Discover the best vacation experience for you by using the travel experience filter on Expedia, whether it's a family-friendly trip to Disneyland Paris or an adventurous hike in the Amazon rainforest.

South America Hotel Deals

Rochester Classic
Rochester Classic
3.5 out of 5
Esmeralda 542, Buenos Aires, Capital Federal
Fully refundableReserve now, pay when you stay
$74 nightly
The price is $77 total per night from Jul 13 to Jul 14
$77 total
Jul 13 - Jul 14
7.8/10 Good! (402 reviews)
"Excellent location in downtown with best value and services. 10 minutes walk to shopping, theaters, restaurants, subway, and 1 block from main retail street (Av. Corrientes = 42nd St in NYC) for taking taxi."

Reviewed on Mar 12, 2023

Rochester Classic
Regal Pacific Buenos Aires
Regal Pacific Buenos Aires
4.5 out of 5
25 De Mayo, 764, Buenos Aires, Capital Federal
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $109 total per night from Jul 28 to Jul 29
$109 total
Jul 28 - Jul 29
8.8/10 Excellent! (999 reviews)
"Very nice hotel and reasonably priced. Staff is quite friendly and responsive. Will stay there again."

Reviewed on May 12, 2025

Regal Pacific Buenos Aires
Concorde Hotel
Concorde Hotel
3 out of 5
25 De Mayo 630, Buenos Aires, Capital Federal
Good located and no expensive hotel in Buenos Aire
"Is an hotel located in micro center of Buenos Aires, near turístic atractives such us Casa Rosada and Puerto Madero, and near a subway station that permits get connected with all the city."

Reviewed on Mar 6, 2018

Get rates
Concorde Hotel
See all 113,440 properties in South America
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

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Kid Friendly Vacations

Kid Friendly Vacations

Frequently asked questions

How much does a South America vacation package cost?
Starting from as little as $428, you can build your own South America package. Simply bundle flights, hotels and car rentals and be rewarded with discounts.
How do I get a cheap travel package to South America?
Our South America vacation packages offer plenty of savings for the savvy explorer. For the best deal, simply combine your hotel, flights and extras (such as activities) into a handy package. But bargain prices are just the beginning of your next unforgettable adventure. When you book with Expedia, and you'll have over 550 air carriers and 1,000,000 properties worldwide to choose from. No matter your style, there's a package here just for you.
How far in advance should I book my South America vacation?
While not all air carriers release tickets early, you can usually look up international flights on Expedia up to 12 months in advance. This is when you can bag some fantastic deals. If you're booking last minute, you could still be in luck. Sometimes the lowest prices emerge just weeks before departure.
What does an Expedia South America travel package include?
Car rentals, hotels and flights --- we bring you the very best deals. All you have to do is decide on your ideal combination. After you've made your booking, you can add on the exciting stuff like experiences and tours. Our travel packages make it easy to craft an unforgettable South America getaway.
What should I know before booking a South America travel package?
So many places to go, so many things to see and do. With a package, you can cross more of them off your list. Combine your flights, rental cars and hotels and see how much you save.
Can I choose my airline with a South America Expedia vacation package?
Expedia offers access to more than 550 airline partners worldwide, so you certainly can. Simply pick your favorite carrier and craft your ideal South America getaway.
Does Expedia offer Book Now, Pay Later South America vacation packages?
Pay the full price for your package booking upfront or split it into multiple installments --- it's your call. Every traveler has their own set of financial circumstances. It's for that reason Expedia has teamed up with online lender Affirm to provide a Book Now, Pay Later option for all vacation packages.
If I'm not able to travel, can I cancel my South America vacation package?
If your vacation plans in South America have changed, it's a relief to know that you can cancel your booking. If you booked less than 24 hours ago, you may be eligible for a refund. If your booking is older than that, your hotel, airline or car rental company may charge a cancellation fee. To find out more, visit our Customer Service Portal.

Discover the most popular places to visit in South America

Historical Museum of Mato Grosso

You can spend an afternoon exploring the galleries in Historical Museum of Mato Grosso during your travels in Cuiabá. Stroll along the riverfront or experience the area's museums.

Historical Museum of Mato Grosso

Republic Square

5/5(1 review)

Learn about the local history of Cuiabá with a stop at Republic Square. Wander the riverfront and parks while you're in the area.

Republic Square

Museu Histórico de Mato Grosso

You can spend time studying the exhibits at Museu Histórico de Mato Grosso during your trip to Cuiabá. Stroll along the riverfront or visit the cathedral while you're in the area.

Museu Histórico de Mato Grosso
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.