Southern Illinois Vacations from $138

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Your Southern Illinois Vacation

Create the ultimate escape with one of our vacation packages to Southern Illinois. Take your time discovering its rich history, spectacular views and loads more things that help make this such an amazing destination. Collinsville, Carbondale and Effingham are just a few of the most well-known cities here. Make sure your trip to Southern Illinois includes a stay in one or all of them! Whether you're planning to travel on a shoestring or in the lap of luxury, Expedia are here to help you organize your next Southern Illinois vacation.

The Latest Southern Illinois Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Alhonna Resort LLC

Alhonna Resort LLC

3 out of 5
per person
Nov 15 - Nov 17
found 2 hours ago
Roundtrip flight included
Phoenix (PHX) to St. Louis (STL)
8.8/10 Excellent! (130 reviews)
Our room was nicer than I expected!

Reviewed on Sep 15, 2024

The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Save 100% on your flight
per person
Dec 4 - Dec 7
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9/10 Wonderful! (1,389 reviews)
One the best stays when on the road

Reviewed on Sep 24, 2024

Holiday Inn Express & Suites St. Louis West - Fenton, an IHG Hotel

Holiday Inn Express & Suites St. Louis West - Fenton, an IHG Hotel

3 out of 5
per person
Nov 25 - Nov 30
found 1 day ago
Roundtrip non-stop flight included
Denver (DEN) to St. Louis (STL)
8.8/10 Excellent! (1,000 reviews)
Average hotel. Clean, but aging and could use some updates. Carpeting was worn and dated.

Reviewed on Sep 22, 2024

The Cheshire

The Cheshire

4 out of 5
Save 100% on your flight
per person
Nov 16 - Nov 19
found 14 hours ago
Roundtrip flight included
Denver (DEN) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
People were very nice, enjoyed the bar and my stay

Reviewed on Sep 22, 2024

The Charles F. Knight Center

The Charles F. Knight Center

2.5 out of 5
per person
Dec 4 - Dec 7
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (192 reviews)
Great short stay.

Reviewed on Sep 7, 2024

Southern Illinois Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)

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Southern Illinois Hotel Deals

Drury Inn & Suites Mt. Vernon
Drury Inn & Suites Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is $132 per night from Sep 30 to Oct 1
$132
includes taxes & fees
$117 per night
Sep 30 - Oct 1
9.6/10 Exceptional! (1,161 reviews)
"Even though construction was going on at the time, it was unnoticeable and still quiet. The food in the morning and the evening was delicious."

Reviewed on Sep 21, 2024

Drury Inn & Suites Mt. Vernon
Walker's Bluff Casino Resort
Walker's Bluff Casino Resort
4.5 out of 5
777 Walkers Bluff Way, Carterville, IL
The price is $134 per night from Sep 29 to Sep 30
$134
includes taxes & fees
$120 per night
Sep 29 - Sep 30
9.2/10 Wonderful! (215 reviews)
"We love staying at Walker Bluff Casino! Great amenities, food, pools & spa. A great place for this area to have."

Reviewed on Sep 5, 2024

Walker's Bluff Casino Resort
Drury Inn & Suites St. Louis O'Fallon, IL
Drury Inn & Suites St. Louis O'Fallon, IL
3 out of 5
1118 Central Park Drive, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is $141 per night from Oct 6 to Oct 7
$141
includes taxes & fees
$121 per night
Oct 6 - Oct 7
9.4/10 Exceptional! (1,005 reviews)
"Did not use any of the amenities but it was a very nice room and bed for an overnight stay."

Reviewed on Sep 23, 2024

Drury Inn & Suites St. Louis O'Fallon, IL
See all 940 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Southern Illinois

Image for Southern Illinois University

Southern Illinois University

4.5/5(173 reviews)

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Southern Illinois University
Image for Garden of the Gods Recreation Area

Garden of the Gods Recreation Area

5/5(6 reviews)

See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.

Garden of the Gods Recreation Area
Image for Giant City State Park

Giant City State Park

4.5/5(78 reviews)

Walk amid mystical woodland, admire geological wonders, go horseback riding and camp in the wilderness in the spectacular countryside of Southwest Illinois.

Giant City State Park

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.