A forested valley with autumn foliage, a rocky cliff, and a sunset.

Southern Illinois Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Jul 31 - Aug 2
In two months
Sep 11 - Sep 13
In three months
Oct 9 - Oct 11
In four months
Nov 6 - Nov 8

Our top choices for Southern Illinois vacation rentals

House (2 Bedrooms) | Front of property

Lakefront Family Home 13 Mi From Gateway Arch!

Lakefront Family Home 13 Mi From Gateway Arch!
3.0 star property
Granite City
2.0 out of 10, (1 review)
$414 nightly
The price is $459
Jul 15 - Jul 16
Total with taxes and fees
Lakefront Family Home 13 Mi From Gateway Arch!
House (2 Bedrooms) | Front of property

Illinois Vacation Rental Home: Pets Welcome

Illinois Vacation Rental Home: Pets Welcome
3.0 star property
Palestine
10.0 out of 10, Exceptional, (1 review)
$327 nightly
The price is $346
Jul 15 - Jul 16
Total with taxes and fees
Illinois Vacation Rental Home: Pets Welcome
House (1 Bedroom) | Front of property

Pet Friendly! Countryside Couples Stay in Illinois

Pet Friendly! Countryside Couples Stay in Illinois
2.5 star property
Murphysboro
$218 nightly
The price is $242
Jul 15 - Jul 16
Total with taxes and fees
Pet Friendly! Countryside Couples Stay in Illinois
Interior

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.6 out of 10, Exceptional, (4 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
$146 nightly
The price is $167
Aug 2 - Aug 3
Total with taxes and fees
The Atrium - A Boutique Hotel
View from property

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (86 reviews)
"I really enjoyed my time at the stay !"
United States
Ronrecus
$133 nightly
The price is $143
Aug 13 - Aug 14
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Full-size fridge, microwave, oven, stovetop

Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.4 out of 10, Exceptional, (22 reviews)
"Family of 4 with young kids. Wonderful host, immaculately kept property and right next door to a great food/drinks joint. We were impressed and would return without hesitation."
United States
Amar
$295 nightly
The price is $338
Jul 15 - Jul 16
Total with taxes and fees
Urban Lofts
Studio Suite, 1 King Bed | Desk, laptop workspace, blackout drapes, WiFi

Value Suites Extended Stay - St Louis

Value Suites Extended Stay - St Louis
3.0 star property
Westport
7.0 out of 10, Good, (1,110 reviews)
"We’ve stayed here twice before and have always been pleased with everything. Very good hotel close to what we need."
United States
Timothy
$441 nightly
The price is $512
Aug 3 - Aug 4
Total with taxes and fees
Value Suites Extended Stay - St Louis
Lobby

White House at Grand Central

White House at Grand Central
3.5 star property
Grand Center
8.4 out of 10, Very Good, (144 reviews)
"The space was very clean, cozy and quiet. There was plenty of room to be comfortable to both rest and have time to get work done or relax in the living room area. The location was very convenient for everything we were visiting St Louis for! (We could walk to both the Fabulous Fox Theatre and Foundry - about 15 min each, and it was a very short trip to the Enterprise Center)"
United States
Jordan
$124 nightly
The price is $139
Aug 11 - Aug 12
Total with taxes and fees
White House at Grand Central
House (2 Bedrooms) | Interior

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
$271 nightly
The price is $290
Aug 2 - Aug 3
Total with taxes and fees
Quiet Country Stay: Modern Home Near Paducah
Interior

3323: Uptown Elegant Escape by JZ Vacation Rentals

3323: Uptown Elegant Escape by JZ Vacation Rentals
2.0 star property
The Gate
$923 nightly
The price is $1,079
Jul 26 - Jul 27
Total with taxes and fees
3323: Uptown Elegant Escape by JZ Vacation Rentals
Terrace/patio

Tiny Houses of French Village

Tiny Houses of French Village
2.5 star property
French Village
10.0 out of 10, Exceptional, (5 reviews)
$347 nightly
The price is $369
Jul 15 - Jul 16
Total with taxes and fees
Tiny Houses of French Village
House, Multiple Beds, Patio, City View ((#19) 3323 Vista Ave) | Private kitchen

Uptown Elegant Escape | JZ Vacation Rentals

Uptown Elegant Escape | JZ Vacation Rentals
2.0 star property
The Gate
$810 nightly
The price is $948
Jul 26 - Jul 27
Total with taxes and fees
Uptown Elegant Escape | JZ Vacation Rentals
Basic Apartment, 2 Bedrooms, Non Smoking | Private kitchen

Spacious 2BR unit near BJ Hospital

Spacious 2BR unit near BJ Hospital
2.0 star property
Central West End
2.0 out of 10, (1 review)
"Do not stay here, the host never responded to any messages and we were unable to checkin. We were left seeking other accommodations after hotels.com took almost full payment for a months stay from us and has yet to return it because “they cannot reach the host” . This is a lot of money to be held from us unavailable to make another booking to replace this one. It has been almost 2 months and hotels.com is not responding to my emails about my refund. "
United States
Eric
$148 nightly
The price is $173
Jul 16 - Jul 17
Total with taxes and fees
Spacious 2BR unit near BJ Hospital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Southern Illinois Hotel Reviews

Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

10/10 Excellent
"Clean, spacious room. Fitness center was good, the machines were in excellent condition, the cable weight machine worked well. Breakfast was good. Plenty of parking. Safe premises, at least it seemed to be the night I stayed. The only negative for me was the pillows were the typical hotel pillows that have no firmness to them, your head just sinks into the pillow, no support at all. Some people like pillows like that but for me they're useless."
Frank 1-night trip
Posted 3 hours ago
Best Western St. Louis Fairview Heights

Find out more about Southern Illinois

Everything you need to know about Southern Illinois vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southern Illinois vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southern Illinois vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southern Illinois vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southern Illinois. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Southern Illinois in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $130 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Southern Illinois rentals

At Expedia, we put the best Southern Illinois vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southern Illinois rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southern Illinois vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southern Illinois. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia