Texas Medical Center Vacations from $260
Book a Hotel + Flight or Car together to unlock savings
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Palace Inn Blue Edgebrook
Southeast Houston
Save 100% on your flight
Price was $471, price is now $260 per person
$260
per person
Mar 7 - Mar 12
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.4/10 Exceptional! (142 reviews)
Such a great place to stay! Absolutely amazing!
Reviewed on Oct 13, 2025
Moody Gardens Hotel, Spa and Convention Center
Near West End
Save 100% on your flight
Price was $545, price is now $294 per person
$294
per person
Feb 13 - Feb 15
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.8/10 Excellent! (1,926 reviews)
Clean and good rooms. Lobby staff attentive
Reviewed on Dec 22, 2025
Reside Houston Dwntwn, Wyndham
Downtown Houston
Save 100% on your flight
Price was $1,045, price is now $599 per person
$599
per person
Mar 9 - Mar 14
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.6/10 Excellent! (832 reviews)
Clean rooms, very nice front desk staff.
Reviewed on Dec 12, 2025
Kompose Residences Houston Cy-Fair
Save 100% on your flight
Price was $508, price is now $297 per person
$297
per person
Mar 7 - Mar 12
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
10/10 Exceptional! (2 reviews)
I haven't ever given a Hotel a 5 star. From check in/guest services to the very adorable lady that keep the breakfast bar well stocked. Our room was wonderful we didn't use the cleaning services but spoke to the lady that was responsible to clean our room she was also great.
Reviewed on Dec 22, 2025
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $993, price is now $611 per person
$611
per person
Jan 28 - Feb 1
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,006 reviews)
No free breakfast, no microwave (rediculous), very hard to find light switches for lamps, no wifii, parking far from entrance altho shuttle was helpful. Beautiful sunrise and sunset…..oh wait…God made those.
Reviewed on Dec 4, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $153 total per night from Jan 18 to Jan 19
$153 total
Jan 18 - Jan 19, 2026
Total with taxes and fees
9/10 Wonderful! (3,601 reviews)
All was good
Reviewed on Dec 17, 2025
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $103 total per night from Jan 3 to Jan 4
$103 total
Jan 3 - Jan 4, 2026
Total with taxes and fees
8.2/10 Very Good! (1,772 reviews)
Room was spotless, everyone was super great. No breakfast or microwave was a setback and the parking fee boosted the rate up. The shuttle was extremely handy. But, the hotel was super nice.
Reviewed on Dec 20, 2025
The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD Houston TX
Fully refundableReserve now, pay when you stay
$163 nightly
The price is $189 total per night from Dec 24 to Dec 25
$189 total
Dec 24 - Dec 25
Total with taxes and fees
9/10 Wonderful! (1,025 reviews)
Service
Reviewed on Dec 20, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Texas Children's Hospital
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Houston Museum of Natural Science General Admission Ticket
$25
per adult
96% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
$15
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
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- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.