Texas Medical Center Vacations from $144
Book a Hotel + Flight or Car together to unlock savings
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Holiday Inn & Suites Houston NW - Willowbrook by IHG
Deco
Save 100% on your flight
Price was $218, price is now $144 per person
$144
per person
Jan 15 - Jan 18
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.8/10 Excellent! (386 reviews)
Clean, updated, ample parking . Breakfast “not” remarkable
Reviewed on Dec 6, 2025
Palace Inn Blue Edgebrook
Southeast Houston
Save 100% on your flight
Price was $618, price is now $328 per person
$328
per person
Feb 27 - Mar 5
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Houston (IAH)
9.4/10 Exceptional! (142 reviews)
Such a great place to stay! Absolutely amazing!
Reviewed on Oct 13, 2025
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $466, price is now $302 per person
$302
per person
Feb 5 - Feb 8
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,006 reviews)
No free breakfast, no microwave (rediculous), very hard to find light switches for lamps, no wifii, parking far from entrance altho shuttle was helpful. Beautiful sunrise and sunset…..oh wait…God made those.
Reviewed on Dec 4, 2025
Staybridge Suites Houston - Medical Center by IHG
Braeswood Place
Save 100% on your flight
Price was $666, price is now $437 per person
$437
per person
Feb 20 - Feb 27
found 17 hours ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9/10 Wonderful! (793 reviews)
The hotel is an excellent place to stay. Love the staff, cleanliness, parking. The social time is unique and breakfast was great.
Reviewed on Dec 5, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $154 total per night from Jan 11 to Jan 12
$154 total
Jan 11 - Jan 12, 2026
Total with taxes and fees
9/10 Wonderful! (3,596 reviews)
The rooms are truly beautiful and the restroom is so spacious.
Reviewed on Dec 12, 2025
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $105 total per night from Dec 22 to Dec 23
$105 total
Dec 22 - Dec 23
Total with taxes and fees
8.2/10 Very Good! (1,730 reviews)
If the room had a microwave our stay would have been perfect.
Reviewed on Dec 9, 2025
InterContinental Houston by IHG
6750 Main St Houston TX
Fully refundable
$164 nightly
The price is $192 total per night from Dec 18 to Dec 19
$192 total
Dec 18 - Dec 19
Total with taxes and fees
9.2/10 Wonderful! (1,003 reviews)
I have not stayed in an Intercontinental hotel in a while and this hotel makes me want to search for Intercontinental first before I look at other hotels. Really wonderful at every turn.
Reviewed on Dec 8, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
MD Anderson Cancer Center
4.5/5(788 reviews)
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Texas Children's Hospital
4.5/5(26 reviews)
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
$15
per adult
100% of travellers recommend
Houston Museum of Natural Science General Admission Ticket
$25
per adult
96% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
- Hotels near MD Anderson Cancer Center
- Hotels near Downtown Houston
- Hotels near NRG Stadium
- Cheap Hotels in Houston
- Hotels near TMC Transit Center
- Condo Rentals in TMC Transit Center
- Apartments in Dryden/TMC Station
- Hotels near Dryden/TMC Station
- Aparthotels in Dryden/TMC Station
- Hotels near Smith Lands Station
- Hotels near Houston Zoo
- Hotels near Astrodome
- Apartments in Memorial Hermann Hospital/Houston Zoo Station
- Vacation Homes in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Memorial Hermann Hospital/Houston Zoo Station
- Resorts in Memorial Hermann Hospital/Houston Zoo Station
- Condo Rentals in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Reckling Park
- Hotels near Rice University
- Hotels near Hermann Park
- Hotels near Rice Stadium
- Hotels near Miller Outdoor Theater
- Hotels near NRG Center
- Apartments in Stadium Park/Astrodome Station
- Hotels near Stadium Park/Astrodome Station
- Hotels near Houston Museum District
- Hotels near James Turrell's Twilight Epiphany Skyscape
- Hotels near Riverside Terrace
- Hotels near Houston Natural Science Museum
- Hotels near NRG Park
- Pet-friendly Hotels in Houston Museum District
- Historic Hotels in Houston Museum District
- Hotels with Free Breakfast in Houston Museum District
- Family Hotels in Houston Museum District
- Boutique Hotels in Houston Museum District
- Hotels with Free Parking in Houston Museum District
- Cheap Hotels in Houston Museum District
- Hotels with a Gym in Houston Museum District
- Luxury Hotels in Houston Museum District
- Resorts & Hotels with Spas in Houston Museum District
- Hotels with an Indoor Pool in Houston Museum District
- 5 Star Hotels in Houston Museum District
- Hotels with Hot Tubs in Houston Museum District
- Hyatt Hotels in Houston Museum District
- Hotels with Early Check-in in Houston Museum District
- Casino Hotels in Houston Museum District
- 3 Star Hotels in Houston Museum District
- Hotels with Connecting Rooms in Houston Museum District
- 4 Star Hotels in Houston Museum District
- Winery Hotels in Houston Museum District
- Hotels with Bars in Houston Museum District
- Adults Only Resorts & in Houston Museum District
- Motel 6 Hotels in Houston Museum District
- Wyndham Hotels in Houston Museum District
- Romantic Hotels in Houston Museum District
- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.