West Main Historic District Vacations from $401

Book a Hotel + Flight or Car together to unlock savings

    deals illustration

    Better together

    Save up to $1,045 when you book a flight and hotel together*
    stays illustration

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    luggage illustration

    Rest easy

    Plan, book, and manage your trip all in one place

Your West Main Historic District Vacation

Organizing your next exciting getaway just got easier with a vacation package to West Main Historic District. Embrace the best this neighborhood has to offer while making nice memories you won't forget. Can't wait to get out and see the sights during your trip to West Main Historic District? Make sure you check out nearby attractions such as Muhammad Ali Center, KFC Yum Center and University of Louisville. Expedia will help turn your dream West Main Historic District vacation into reality, whatever your travel plans or budget.

The Latest West Main Historic District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites Louisville Downtown by IHG

Holiday Inn Express & Suites Louisville Downtown by IHG

2.5 out of 5
Downtown Louisville
per person
Sep 25 - Sep 28
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Louisville (SDF)
8.8/10 Excellent! (1,478 reviews)
No complaints about the hotel itself.

Reviewed on Jul 10, 2025

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham

4 out of 5
Downtown Louisville
Save 100% on your flight
per person
Sep 18 - Sep 22
found 4 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Louisville (SDF)
8.8/10 Excellent! (3,438 reviews)
I enjoyed this stay at Galt House. The location is convenient, the rooms are nice, there are good restaurants onsite and close by. I will point out a couple of things that I did not like as much, but will note that these are minor and that I do plan on staying there again soon. The $30 a night parking feels a bit excessive. Also, as the hotel is next to a convention center and sports stadiums, it changes the atmosphere as the hotel become very busy. The staff gets overwhelmed, there are lines for everything, and it is just loud. I recommend going to Galt House when there are not conventions or sporting events, it is a much nicer experience.

Reviewed on Jul 11, 2025

Hyatt Regency Louisville

Hyatt Regency Louisville

4 out of 5
Downtown Louisville
per person
Sep 25 - Sep 28
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Louisville (SDF)
8.8/10 Excellent! (1,003 reviews)
Staff was incredible. Room was okay, but not excellent, as the bathroom was not well-cleaned or ventilated.

Reviewed on Jun 26, 2025

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown

4 out of 5
Downtown Louisville
per person
Sep 25 - Sep 28
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Louisville (SDF)
8.8/10 Excellent! (1,008 reviews)
Nice hotel . Clean. Small room

Reviewed on Jul 9, 2025

Louisville Marriott Downtown

Louisville Marriott Downtown

4 out of 5
Downtown Louisville
per person
Sep 25 - Sep 28
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Louisville (SDF)
9/10 Wonderful! (1,004 reviews)
Beautiful hotel and excellent service. Location is great too. Will stay at the Marriott when back in Louisville

Reviewed on Jul 5, 2025

Where to stay in West Main Historic District

Find the best West Main Historic District areas and neighborhoods for the activities you enjoy most. Learn more about West Main Historic District
Louisville showing signage and street scenes as well as a small group of people

Downtown Louisville

4 out of top 10 points of interest in this area
4/5(1,812 area reviews)

Explore "Museum Row" in the West Main District, catch a game at Louisville Slugger Field, or stroll across the pedestrian-only Big Four Bridge. Enjoy diverse attractions, restaurants, and the Louie Link skywalk.

Find hotels in Downtown Louisville

West Main Historic District Hotel Deals

Galt House Hotel Trademark Collection by Wyndham
Galt House Hotel Trademark Collection by Wyndham
4 out of 5
140 North Fourth Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $167 total per night from Aug 10 to Aug 11
$167 total
Aug 10 - Aug 11
Total includes taxes and fees
8.8/10 Excellent! (3,441 reviews)
"I enjoyed this stay at Galt House. The location is convenient, the rooms are nice, there are good restaurants onsite and close by. I will point out a couple of things that I did not like as much, but will note that these are minor and that I do plan on staying there again soon. The $30 a night parking ..."

Reviewed on Jul 11, 2025

Galt House Hotel Trademark Collection by Wyndham
Omni Louisville Hotel
Omni Louisville Hotel
4 out of 5
400 S. 2nd Street, Louisville, KY
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $187 total per night from Aug 8 to Aug 9
$187 total
Aug 8 - Aug 9
Total includes taxes and fees
9.2/10 Wonderful! (1,502 reviews)
"beautiful hotel. great location"

Reviewed on Jul 10, 2025

Omni Louisville Hotel
Holiday Inn Express & Suites Louisville Downtown by IHG
Holiday Inn Express & Suites Louisville Downtown by IHG
2.5 out of 5
800 W Market St, Louisville, KY
Fully refundable
$83 nightly
The price is $98 total per night from Aug 4 to Aug 5
$98 total
Aug 4 - Aug 5
Total includes taxes and fees
8.6/10 Excellent! (1,487 reviews)
"No complaints about the hotel itself."

Reviewed on Jul 10, 2025

Holiday Inn Express & Suites Louisville Downtown by IHG
See all 1,997 properties in West Main Historic District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in West Main Historic District

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Doc Crow's is perfect downtown spot for brisket and barbeque and has the tastiest drinks, especially the Man on Fire

Whiskey Row

Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Whiskey Row
Muhammad Ali Center featuring modern architecture and night scenes

Muhammad Ali Center

4.5/5(243 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center

Things to do

Louisville: Photoshoot Walking Tour with Pictures

Louisville: Photoshoot Walking Tour with Pictures

$55
per adult
Louisville: Photoshoot Walking Tour with Pictures
Louisville: Prohibition, Ghosts, Cocktails and Bites Tour

Louisville: Prohibition, Ghosts, Cocktails and Bites Tour

$179
per adult
Louisville: Prohibition, Ghosts, Cocktails and Bites Tour
Smartphone-Guided Walking Tour of Downtown Louisville Sights & Stories

Smartphone-Guided Walking Tour of Downtown Louisville Sights & Stories

$15
per traveler
Smartphone-Guided Walking Tour of Downtown Louisville Sights & Stories
See all activities in Louisville
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.