Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

Aparthotel in El Poblado

Haven
4.0 star property
8.8 out of 10, Excellent, (647)
"This hotel was amazing. The staff was great and my overall stay was 10/10"
United States
Alvin Ammaad
$107 nightly
The price is $107
Jan 12 - Jan 13
Haven

Chalet in San Vicente

Shabbat Hotel Boutique
2.0 star property
10.0 out of 10, Exceptional, (2)
"Excelente Servicio y facilidades. 100% recomendado"
United States
william
$71 nightly
The price is $71
Jan 12 - Jan 13
Shabbat Hotel Boutique

Cabin in El Rosario

Skyline Ecoliving
3.0 star property
9.2 out of 10, Wonderful, (38)
"Best views ever! The staff was always amazing, and it was the perfect spot to escape the city noise for a little while."
United States
Andres
$71 nightly
The price is $71
Jan 19 - Jan 20
Skyline Ecoliving
4.0 star property
9.6 out of 10, Exceptional, (1434)
"Excellent place to stay, the staff is amazing! I definitely recommend this place, two tumbs up!!"
United States
Efrain
$139 nightly
The price is $139
Feb 1 - Feb 2
York Medellin, Curio Collection by Hilton
4.5 star property
7.4 out of 10, Good, (56)
"Clean room and good amenities. Close to the airport which was useful after a long flight "
Australia
DAVID
$95 nightly
The price is $95
Jan 9 - Jan 10
Hotel Rioverde- 5 minutos de cercanía al aeropuerto
3.0 star property
10.0 out of 10, Exceptional, (4)
"Nice place "
United States
GERARDO
$73 nightly
The price is $73
Jan 13 - Jan 14
Wasikuna cabañas rurales tipo glamping

Apartment in El Poblado

Seissta Medellin
4.0 star property
9.2 out of 10, Wonderful, (214)
"Great staff, nice units, very well maintained. Very quiet"
United States
Christopher
$125 nightly
The price is $125
Jan 21 - Jan 22
Seissta Medellin

Chalet in Girardota

Sky View Glamping
2.0 star property
9.0 out of 10, Wonderful, (2)
"Great view and the hospitality was very good.. The cabins were clean. "
United States
Chris
$107 nightly
The price is $107
Jan 12 - Jan 13
Sky View Glamping
3.0 star property
8.8 out of 10, Excellent, (3)
"Hot tub outside was an experience. Very clean "
United States
FRANK
$128 nightly
The price is $128
Jan 12 - Jan 13
Cumbres Luxury Glamping

Apartment in El Poblado

Royal Living Poblado
4.0 star property
9.2 out of 10, Wonderful, (52)
"Comfortable and safe stay"
United States
Julian
$56 nightly
The price is $56
Jan 20 - Jan 21
Royal Living Poblado
3.5 star property
8.4 out of 10, Very Good, (467)
"Good property. "
United States
Ruth Marcela
$70 nightly
The price is $70
Jan 11 - Jan 12
Travelers Rio Verde Living Suites

Apartment in El Poblado

Go Living and Suites by Jalo
3.0 star property
9.4 out of 10, Exceptional, (81)
"Great place for a getaway"
United States
Mateusz
$53 nightly
The price is $53
Jan 15 - Jan 16
Go Living and Suites by Jalo

Apartment in San Diego

Metropolitan Living by HOUSY
4.0 star property
9.4 out of 10, Exceptional, (29)
"Great location."
United States
Nekitta
$76 nightly
The price is $76
Jan 12 - Jan 13
Metropolitan Living by HOUSY
5.0 star property
7.6 out of 10, Good, (11)
"We had a really good experience. They were super helpful and friendly. "
Canada
Carolina
$169 nightly
The price is $169
Jan 12 - Jan 13
Country hotel near Jose Maria Cordova Airport

Cabin in Rionegro

Casa Los Curazaos
3.5 star property
$108 nightly
The price is $108
Jan 11 - Jan 12
Casa Los Curazaos

Apartment in Rionegro

Mali Experience
3.0 star property
$63 nightly
The price is $63
Jan 13 - Jan 14
Mali Experience

Aparthotel in El Poblado

Sites Hotel
4.0 star property
9.2 out of 10, Wonderful, (1111)
"Very clean and spacious for a family of 4"
United States
damian
$91 nightly
The price is $91
Jan 12 - Jan 13
Sites Hotel
3.0 star property
8.8 out of 10, Excellent, (42)
"Everything was perfect"
United States
Ancizar
$57 nightly
The price is $57
Jan 13 - Jan 14
PORTANOVA SUITES by ADVENTU

Apartment in Rionegro

Edificio Cielo Verde
3.0 star property
$166 nightly
The price is $166
Jan 28 - Jan 29
Edificio Cielo Verde

Aparthotel in Marinilla

Apartahotel mirador campestre
3.5 star property
Apartahotel mirador campestre
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $26 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

La Gracia Hotel & Spa: Visitors like this Santa Cruz vacation home rental. It offers a terrace, a garden, and free WiFi to help you feel perfectly comfortable in your new surroundings.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.