Default HTG hotel image

Santa Cruz Vacation Rentals

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

In two weeks
Sep 4 - Sep 6
In two months
Oct 16 - Oct 18
In three months
Nov 13 - Nov 15
In four months
Dec 11 - Dec 13

Our top choices for Santa Cruz vacation rentals

Deluxe Apartment, 1 Queen Bed with Sofa bed, Non Smoking, Kitchen | 1 bedroom, premium bedding, down comforters, in-room safe

1. Portal del Rodeo ApartaHotel - Arkadia Mall

Portal del Rodeo ApartaHotel - Arkadia Mall
3.5 star property
Medellín
9.2 out of 10, Wonderful, (292 reviews)
"Excellent place to stay with family and friends!"
Canada
Jose
$65 nightly
The price is $65
Aug 24 - Aug 25
Portal del Rodeo ApartaHotel - Arkadia Mall
Reception

2. Sites Hotel

Sites Hotel
4.0 star property
El Poblado
9.2 out of 10, Wonderful, (1,157 reviews)
"Excelente hotel."
United States
Fernanda
$91 nightly
The price is $91
Sep 22 - Sep 23
Sites Hotel
Minibar, desk, laptop workspace, blackout drapes

3. Mali Experience

Mali Experience
3.0 star property
Rionegro
9.6 out of 10, Exceptional, (9 reviews)
"Perfect property ! Big enough. Big fridge, full kitchen; excellent bathroom and bed. The whole room is full little details and excellent design!"
United States
Jorge
$87 nightly
The price is $87
Aug 25 - Aug 26
Mali Experience
Studio | View from room

4. Travelers Rio Verde Living Suites

Travelers Rio Verde Living Suites
3.5 star property
Rionegro
8.4 out of 10, Very Good, (488 reviews)
"Good"
United States
Christian
$99 nightly
The price is $99
Aug 24 - Aug 25
Travelers Rio Verde Living Suites
Lobby

5. Haven, A Design Hotel

Haven, A Design Hotel
4.0 star property
El Poblado
8.8 out of 10, Excellent, (725 reviews)
"Good place to had good vacations"
United States
Nicole
$91 nightly
The price is $91
Aug 24 - Aug 25
Haven, A Design Hotel
Front of property

6. Seissta Medellin

Seissta Medellin
4.0 star property
El Poblado
9.4 out of 10, Exceptional, (278 reviews)
"I stayed here for about a week and a half and to say the least the Property was very clean the staff were always attentive to my needs and were very professional the room was also very good Balcony was Breathtaking and Everything about this place I liked a lot I’m planning on staying here again next time I Land in Colombia def reccomend!"
United States
Valentin chavez
$110 nightly
The price is $110
Aug 24 - Aug 25
Seissta Medellin
Restaurant

7. Edificio Helena

Edificio Helena
3.0 star property
Medellín
8.8 out of 10, Excellent, (69 reviews)
"Awesome breakfast, great location. Great host"
United States
James
$35 nightly
The price is $35
Sep 22 - Sep 23
Edificio Helena
Terrace/patio

8. Encanto Verde

Encanto Verde
2.5 star property
Marinilla
$50 nightly
The price is $50
Aug 24 - Aug 25
Encanto Verde
Luxury Studio | In-room safe, desk, laptop workspace, soundproofing

9. Go Living and Suites by Jalo

Go Living and Suites by Jalo
3.0 star property
El Poblado
9.2 out of 10, Wonderful, (128 reviews)
"Good choice, close to Poblado, good space, fully endowed"
United States
Jorge H
$60 nightly
The price is $60
Aug 24 - Aug 25
Go Living and Suites by Jalo
Comfort Double Room | Premium bedding, down comforters, minibar, WiFi (free)

10. Hotel Moore 45

Hotel Moore 45
4.0 star property
Buenos Aires
8.8 out of 10, Excellent, (3 reviews)
"I like the service and it’s really comfortable. And the people in their recession. Bety. Help. Take you guys. I Enjoy the State. I’m planning to Come Back. How old is go back to the hotel again!"
United States
Welinton
$24 nightly
The price is $24
Aug 26 - Aug 27
Hotel Moore 45
Elite Studio | In-room safe, blackout drapes, iron/ironing board (on request)

11. Origen Local Suites

Origen Local Suites
3.0 star property
Laureles
9.4 out of 10, Exceptional, (212 reviews)
"Great place.!"
United States
jeremy
$56 nightly
The price is $56
Sep 23 - Sep 24
Origen Local Suites
Free daily full breakfast

12. Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House

Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
3.5 star property
Laureles
9.2 out of 10, Wonderful, (102 reviews)
"Excellent breakfast, good location "
United States
dickie
$46 nightly
The price is $46
Aug 27 - Aug 28
Laureles Grand House LGH Hotel - Anteriormente Laureles Guest House
Deluxe Suite, 2 Bedrooms, Mountain View | Premium bedding, down comforters, Select Comfort beds, minibar

13. Hotel Boutique Almaia 17 Near the Airport

Hotel Boutique Almaia 17 Near the Airport
3.0 star property
Rionegro
$58 nightly
The price is $58
Sep 23 - Sep 24
Hotel Boutique Almaia 17 Near the Airport
Living area

14. Skyline Ecoliving

Skyline Ecoliving
3.0 star property
El Rosario
9.4 out of 10, Exceptional, (43 reviews)
"Exelente servicio"
United States
Ernesto
$77 nightly
The price is $77
Aug 27 - Aug 28
Skyline Ecoliving
1 bedroom, premium bedding, down comforters, WiFi (free)

15. Shabbat Hotel Boutique

Shabbat Hotel Boutique
4.0 star property
San Vicente
9.4 out of 10, Exceptional, (3 reviews)
"El jacuzzi no está protegido, se ensucia muy fácil con la lluvia y las hojas que caen de los árboles."
Colombia
Camilo
$118 nightly
The price is $118
Sep 8 - Sep 9
Shabbat Hotel Boutique
Standard Apartment, 1 Double Bed | View from room

16. San Peter Suites

San Peter Suites
3.0 star property
Laureles
8.0 out of 10, Very Good, (54 reviews)
"This ia a great place, super relaxed and friendly staff "
United States
Duncan
$65 nightly
The price is $65
Aug 24 - Aug 25
San Peter Suites
Apartment (806) | Living area | 50-inch Smart TV with cable channels, TV

17. Apartment Go Living & Suites by HOUSY HOST

Apartment Go Living & Suites by HOUSY HOST
3.5 star property
El Poblado
8.4 out of 10, Very Good, (448 reviews)
"Close to everything !"
United States
Marc
$72 nightly
The price is $72
Aug 24 - Aug 25
Apartment Go Living & Suites by HOUSY HOST
Apartment, 3 Bedrooms | Terrace/patio

18. Wake Living

Wake Living
4.0 star property
El Poblado
9.0 out of 10, Wonderful, (222 reviews)
"Great place"
United States
Pedro
$166 nightly
The price is $166
Aug 24 - Aug 25
Wake Living
Deluxe Apartment #201 | 1 bedroom, premium bedding, pillowtop beds, in-room safe

19. Soul Lifestyle Apartments

Soul Lifestyle Apartments
3.5 star property
El Poblado
9.0 out of 10, Wonderful, (146 reviews)
"We stayed there for 3 whole weeks and it was really nice. The location is just perfect, the space enough for a family of 4 and the attention and feedback from the front desk just perfect. We will stay there again."
United States
Edward
$131 nightly
The price is $131
Sep 6 - Sep 7
Soul Lifestyle Apartments
Romantic Bungalow, Mountain View | Premium bedding, down comforters, desk, laptop workspace

20. Ancestral Glamping

Ancestral Glamping
2.0 star property
Barbosa
$161 nightly
The price is $161
Aug 26 - Aug 27
Ancestral Glamping
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

Hotel Provenza Garden

Hotel Provenza Garden

8/10 Good
"👍"
Tanisha Marie Morales 3-night trip
Posted less than an hour ago
Hotel Provenza Garden

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $32 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we offer vacation rentals close to popular attractions in Santa Cruz, or you can choose a more secluded option if you want a relaxing place to stay.

What's the top vacation rental in Santa Cruz?

Luxe Retreat Private Jacuzzi, A House Best view and price of North Medellin: Visitors like this Santa Cruz vacation home rental. It offers a balcony, a rooftop terrace, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. You can relax into your vacation with a garden and a hot tub.

What’s there to see and do in Santa Cruz?

While exploring the area, visit family-friendly sights like Pueblito Paisa, or get outside and enjoy nature at Medellin Botanical Garden. In the larger area, you’ll find University of Antioquia and Arvi Park.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties where you can stay for a long or short time in Santa Cruz. Vacation rentals feature extras such as hot tubs, fire pits, and patios so you'll feel just like you're at home. If you're concerned about cleanliness, a vacation rental can offer a sense of safety away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for families.