Texas Medical Center Vacations from $145
Book a Hotel + Flight or Car together to unlock savings
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hilton Houston North
Northside
Save 100% on your flight
Price was $239, price is now $145 per person
$145
per person
Dec 5 - Dec 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,010 reviews)
I enjoyed my stay, the housekeeping are very nice
Reviewed on Oct 13, 2025
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $630, price is now $362 per person
$362
per person
Dec 3 - Dec 6
found 23 hours ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,015 reviews)
Loved our stay over the weekend how’s I wish they would have a microwave in the rooms, to be able to re heat food.
Reviewed on Oct 15, 2025
The Residency Suites
Save 100% on your flight
Price was $404, price is now $246 per person
$246
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip flight included
New York (LGA) to Houston (IAH)
9/10 Wonderful! (222 reviews)
I didn't like the fact that they didn't provide toothpaste. Other than that I enjoined my stay. The room was spacious.
Reviewed on Apr 17, 2025
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Greater Uptown
Save 100% on your flight
Price was $228, price is now $152 per person
$152
per person
Dec 5 - Dec 7
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (2,684 reviews)
It was a great experience
Reviewed on Oct 17, 2025
Hilton Garden Inn Houston/Sugar Land
Save 100% on your flight
Price was $473, price is now $322 per person
$322
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip flight included
New York (LGA) to Houston (IAH)
8.2/10 Very Good! (1,022 reviews)
Great rooms. The staff is excellent. Each and every one of them. I stayed for six days and only encountered the best guest courtesy!
Reviewed on Oct 12, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave, Houston, TX
Fully refundableReserve now, pay when you stay
$153 nightly
The price is $179 total per night from Nov 18 to Nov 19
$179 total
Nov 18 - Nov 19
Total with taxes and fees
9/10 Wonderful! (3,565 reviews)
"Nice hotel Clean Room & Quiet. I did have to wait little but for room to be ready but I was early. Overall was pleased with stay."
Reviewed on Oct 16, 2025
Hilton Houston Plaza/Medical Center
6633 Travis St, Houston, TX
Fully refundableReserve now, pay when you stay
$101 nightly
The price is $118 total per night from Nov 16 to Nov 17
$118 total
Nov 16 - Nov 17
Total with taxes and fees
8.2/10 Very Good! (1,644 reviews)
"Front desk staff extremely nice. After a long drive and arriving late to the hotel they were very helpful and accommodating. Room service was wonderful as well. Excellent room."
Reviewed on Oct 19, 2025
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2, Houston, TX
Fully refundableReserve now, pay when you stay
$136 nightly
The price is $159 total per night from Nov 3 to Nov 4
$159 total
Nov 3 - Nov 4
Total with taxes and fees
9/10 Wonderful! (2,039 reviews)
"Excellent place to stay very clean great customer service!"
Reviewed on Oct 18, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Texas Children's Hospital
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
$25
per adult
100% of travellers recommend
Houston Museum of Natural Science: Cockrell Butterfly Center
$15
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
- Hotels near MD Anderson Cancer Center
- Hotels near Downtown Houston
- Hotels near NRG Stadium
- Cheap Hotels in Houston
- Hotels near TMC Transit Center
- Condo Rentals in TMC Transit Center
- Apartments in Dryden/TMC Station
- Hotels near Dryden/TMC Station
- Aparthotels in Dryden/TMC Station
- Hotels near Smith Lands Station
- Hotels near Houston Zoo
- Hotels near Astrodome
- Apartments in Memorial Hermann Hospital/Houston Zoo Station
- Vacation Homes in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Memorial Hermann Hospital/Houston Zoo Station
- Resorts in Memorial Hermann Hospital/Houston Zoo Station
- Condo Rentals in Memorial Hermann Hospital/Houston Zoo Station
- Hotels near Reckling Park
- Hotels near Rice University
- Hotels near Hermann Park
- Hotels near Rice Stadium
- Hotels near Miller Outdoor Theater
- Hotels near NRG Center
- Apartments in Stadium Park/Astrodome Station
- Hotels near Stadium Park/Astrodome Station
- Hotels near Houston Museum District
- Hotels near James Turrell's Twilight Epiphany Skyscape
- Hotels near Riverside Terrace
- Hotels near Houston Natural Science Museum
- Hotels near NRG Park
- Pet-friendly Hotels in Houston Museum District
- Historic Hotels in Houston Museum District
- Hotels with Free Breakfast in Houston Museum District
- Family Hotels in Houston Museum District
- Boutique Hotels in Houston Museum District
- Hotels with Free Parking in Houston Museum District
- Cheap Hotels in Houston Museum District
- Hotels with a Gym in Houston Museum District
- Luxury Hotels in Houston Museum District
- Resorts & Hotels with Spas in Houston Museum District
- Hotels with an Indoor Pool in Houston Museum District
- 5 Star Hotels in Houston Museum District
- Hotels with Hot Tubs in Houston Museum District
- Hyatt Hotels in Houston Museum District
- Hotels with Early Check-in in Houston Museum District
- Casino Hotels in Houston Museum District
- 3 Star Hotels in Houston Museum District
- Hotels with Connecting Rooms in Houston Museum District
- 4 Star Hotels in Houston Museum District
- Winery Hotels in Houston Museum District
- Hotels with Bars in Houston Museum District
- Adults Only Resorts & in Houston Museum District
- Motel 6 Hotels in Houston Museum District
- Wyndham Hotels in Houston Museum District
- Romantic Hotels in Houston Museum District
- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.