$295 Cheap Flights from Buffalo (BUF) to Mayagüez (MAZ)

View $295 flight on Thu, Nov 20, 2025Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Mayagüez (MAZ-Eugenio María de Hostos)

Cheap Flights from Buffalo to Mayagüez (BUF-MAZ)

Prices were available within the past 7 days and start at $295 for one-way flights and $388 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sun, Nov 30 - Tue, Dec 16
BUF
Buffalo
MAZ
Mayagüez
$388 Roundtrip, found 6 days ago
$388
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Nov 30 from Buffalo to Mayagüez, returning Tue, Dec 16, priced at $388 found 6 days ago
American Airlines
Thu, Dec 4 - Tue, Dec 16
BUF
Buffalo
MAZ
Mayagüez
$408 Roundtrip, found 6 days ago
$408
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 4 from Buffalo to Mayagüez, returning Tue, Dec 16, priced at $408 found 6 days ago
American Airlines
Wed, Nov 19 - Fri, Dec 5
BUF
Buffalo
MAZ
Mayagüez
$420 Roundtrip, found 6 days ago
$420
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 19 from Buffalo to Mayagüez, returning Fri, Dec 5, priced at $420 found 6 days ago
United
Sat, Oct 4 - Fri, Oct 24
BUF
Buffalo
MAZ
Mayagüez
$436 Roundtrip, found 6 days ago
$436
Roundtrip
found 6 days ago
Select United flight, departing Sat, Oct 4 from Buffalo to Mayagüez, returning Fri, Oct 24, priced at $436 found 6 days ago
American Airlines
Sun, Nov 30 - Sat, Dec 20
BUF
Buffalo
MAZ
Mayagüez
$440 Roundtrip, found 6 days ago
$440
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sun, Nov 30 from Buffalo to Mayagüez, returning Sat, Dec 20, priced at $440 found 6 days ago
American Airlines
Sat, Oct 18 - Fri, Nov 7
BUF
Buffalo
MAZ
Mayagüez
$450 Roundtrip, found 6 days ago
$450
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Oct 18 from Buffalo to Mayagüez, returning Fri, Nov 7, priced at $450 found 6 days ago
American Airlines
Wed, Nov 19 - Wed, Dec 3
BUF
Buffalo
MAZ
Mayagüez
$452 Roundtrip, found 6 days ago
$452
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Nov 19 from Buffalo to Mayagüez, returning Wed, Dec 3, priced at $452 found 6 days ago
JetBlue Airways
Mon, Nov 17 - Thu, Dec 4
BUF
Buffalo
MAZ
Mayagüez
$454 Roundtrip, found 6 days ago
$454
Roundtrip
found 6 days ago
Select JetBlue Airways flight, departing Mon, Nov 17 from Buffalo to Mayagüez, returning Thu, Dec 4, priced at $454 found 6 days ago
United
Tue, Oct 7 - Fri, Oct 24
BUF
Buffalo
MAZ
Mayagüez
$456 Roundtrip, found 6 days ago
$456
Roundtrip
found 6 days ago
Select United flight, departing Tue, Oct 7 from Buffalo to Mayagüez, returning Fri, Oct 24, priced at $456 found 6 days ago
American Airlines
Thu, Dec 4 - Sat, Dec 20
BUF
Buffalo
MAZ
Mayagüez
$460 Roundtrip, found 6 days ago
$460
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 4 from Buffalo to Mayagüez, returning Sat, Dec 20, priced at $460 found 6 days ago

Alternative airports near Mayagüez

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Rafael Hernandez BQN. Cheapest option available. Average driving time to city center is 33 minutes. Flights from $274
BQN
Rafael Hernandez
Cheapest
Average driving time to city center33 min
Flights from $274

Frequently asked questions

How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ) cost?
Secure a cheap one-way flight from $295 or cheap return flight from $388 from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ)?
November is the most affordable month to fly from BUF to MAZ. Planning your trip for the off-season is often the key to scoring lower fares.
What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ)?
To find the cheapest airline flying from BUF to MAZ, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ)?
There aren't any daily direct flights from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from BUF to MAZ?
You'll typically find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ)?
To avoid potential delays on the Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ) route, travel before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ) last-minute?
Last-minute fares from BUF to MAZ are typically more expensive. To lock in the best rates, start searching for flights ahead of time. That said, if you're flexible with your travel plans, it's possible to find a cheap ticket right before your journey.
Is it cheaper to book a BUF to MAZ flight and hotel package?
Compared with arranging hotels and flights separately, booking a BUF to MAZ flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one place takes the hassle out of planning your trip. Just secure your flights and choose from our extensive range of hotels, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Eugenio Maria de Hostos Airport (MAZ)?
If you reserved your BUF to MAZ flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

Travel information

Travel information

Origin airport
Buffalo Niagara Intl.
Destination airport
Eugenio María de Hostos
Airlines serving
JetBlue Airways
Roundtrip price
$387
Distance
1834 mi

Book with confidence

Book with confidence

Buffalo to Mayagüez Flights

The cheapest times to fly from Buffalo to Mayagüez

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Mayagüez are during the month of November. You can find some of the cheapest flights from Buffalo to Mayagüez with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Mayagüez

Sunday is one of the best days to book for cheap flights from Buffalo to Mayagüez: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Mayagüez

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Mayagüez in 2025. You can also book with separate airlines for your outbound and return journeys, from $295 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Mayagüez flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Mayagüez airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Buffalo to Mayagüez Flights

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*Available to One Key members.