$265 Cheap Flights from Cheyenne (CYS) to Louisville (SDF)

View $265 flight on Mon, Nov 24, 2025Opens in a new window

Popular airlines from Cheyenne, WY (CYS-Cheyenne Regional) to Louisville Intl. Airport (SDF)

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Cheap Flights from Cheyenne to Louisville (CYS-SDF)

Prices were available within the past 7 days and start at $265 for one-way flights and $328 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, Dec 25 - Tue, Jan 6
CYS
Cheyenne
SDF
Louisville
$328 Roundtrip, found 5 days ago
$328
Roundtrip
found 5 days ago
Select United flight, departing Thu, Dec 25 from Cheyenne to Louisville, returning Tue, Jan 6, priced at $328 found 5 days ago
United
Fri, Nov 28 - Sat, Dec 13
CYS
Cheyenne
SDF
Louisville
$334 Roundtrip, found 5 days ago
$334
Roundtrip
found 5 days ago
Select United flight, departing Fri, Nov 28 from Cheyenne to Louisville, returning Sat, Dec 13, priced at $334 found 5 days ago
United
Wed, Dec 31 - Sat, Jan 17
CYS
Cheyenne
SDF
Louisville
$339 Roundtrip, found 5 days ago
$339
Roundtrip
found 5 days ago
Select United flight, departing Wed, Dec 31 from Cheyenne to Louisville, returning Sat, Jan 17, priced at $339 found 5 days ago
United
Sat, Nov 15 - Sat, Nov 22
CYS
Cheyenne
SDF
Louisville
$353 Roundtrip, found 5 days ago
$353
Roundtrip
found 5 days ago
Select United flight, departing Sat, Nov 15 from Cheyenne to Louisville, returning Sat, Nov 22, priced at $353 found 5 days ago
United
Fri, Nov 14 - Sat, Dec 6
CYS
Cheyenne
SDF
Louisville
$359 Roundtrip, found 5 days ago
$359
Roundtrip
found 5 days ago
Select United flight, departing Fri, Nov 14 from Cheyenne to Louisville, returning Sat, Dec 6, priced at $359 found 5 days ago
United
Sat, Nov 15 - Tue, Nov 18
CYS
Cheyenne
SDF
Louisville
$378 Roundtrip, found 5 days ago
$378
Roundtrip
found 5 days ago
Select United flight, departing Sat, Nov 15 from Cheyenne to Louisville, returning Tue, Nov 18, priced at $378 found 5 days ago
United
Fri, Dec 5 - Mon, Dec 15
CYS
Cheyenne
SDF
Louisville
$386 Roundtrip, found 5 days ago
$386
Roundtrip
found 5 days ago
Select United flight, departing Fri, Dec 5 from Cheyenne to Louisville, returning Mon, Dec 15, priced at $386 found 5 days ago
United
Mon, Nov 17 - Sat, Nov 22
CYS
Cheyenne
SDF
Louisville
$389 Roundtrip, found 5 days ago
$389
Roundtrip
found 5 days ago
Select United flight, departing Mon, Nov 17 from Cheyenne to Louisville, returning Sat, Nov 22, priced at $389 found 5 days ago
United
Fri, Nov 28 - Mon, Dec 8
CYS
Cheyenne
SDF
Louisville
$392 Roundtrip, found 5 days ago
$392
Roundtrip
found 5 days ago
Select United flight, departing Fri, Nov 28 from Cheyenne to Louisville, returning Mon, Dec 8, priced at $392 found 5 days ago
United
Thu, Nov 27 - Sat, Dec 13
CYS
Cheyenne
SDF
Louisville
$394 Roundtrip, found 5 days ago
$394
Roundtrip
found 5 days ago
Select United flight, departing Thu, Nov 27 from Cheyenne to Louisville, returning Sat, Dec 13, priced at $394 found 5 days ago

Alternative airports near Louisville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Louisville Intl. SDF. Cheapest and Closest option available. Average driving time to city center is 9 minutes. Flights from $353
SDF
Louisville Intl.
CheapestClosest
Average driving time to city center9 min
Flights from $353

Frequently asked questions

How much does a flight from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF) cost?
Get a cheap one-way flight from $265 or cheap return flight from $328 from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF)?
Traveling in December can help you save, as it's the cheapest month for flights between CYS and SDF. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF)?
Expedia's filter tool lets you easily compare different airlines, flight durations and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest CYS to SDF flight.
How many flights per day from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF)?
You'll need to catch a flight with a layover when traveling from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF). Direct flights don't operate daily on this route. However, simply filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from CYS to SDF?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a range of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF)?
To avoid potential delays on the Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF) route, aim to travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF) last-minute?
Holding off until right before your break to book your flight from CYS to SDF generally means paying more. Although you may find some last-minute deals, they're not always guaranteed. Keep your travel plans flexible for a better chance of getting a bargain.
Is it cheaper to book a CYS to SDF flight and hotel package?
You'll typically save money by securing a CYS to SDF flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. After choosing your preferred flights and accommodations, consider adding extras such as car rentals, tours and activities.
Can I cancel or change the date of my flight from Cheyenne Regional Airport (CYS) to Louisville Intl. Airport (SDF)?
If you booked your CYS to SDF flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Travel information

Origin airport
Cheyenne Regional
Destination airport
Louisville Intl.
Roundtrip price
$328
Distance
1032 mi

Book with confidence

Cheyenne to Louisville Flights

The cheapest times to fly from Cheyenne to Louisville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cheyenne to Louisville are during the month of December. You can find some of the cheapest flights from Cheyenne to Louisville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cheyenne to Louisville

Sunday is one of the best days to book for cheap flights from Cheyenne to Louisville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cheyenne to Louisville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cheyenne to Louisville in 2025. You can also book with separate airlines for your outbound and return journeys, from $265 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cheyenne to Louisville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cheyenne to Louisville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cheyenne to Louisville Flights

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*Available to One Key members.