$155 Cheap Flights from Medford (MFR) to Manzanillo (ZLO)

View $155 flight on Tue, Mar 10, 2026Opens in a new window

Popular airlines from Rogue Valley Intl. Airport (MFR) to Manzanillo, Colima (ZLO-Playa de Oro Intl.)

Cheap Flights from Medford to Manzanillo (MFR-ZLO)

Prices were available within the past 7 days and start at $155 for one-way flights and $346 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$346 Roundtrip, found 2 days ago
$346
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $346 found 2 days ago
Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$351 Roundtrip, found 2 days ago
$351
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $351 found 2 days ago
Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$353 Roundtrip, found 2 days ago
$353
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $353 found 2 days ago
Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$364 Roundtrip, found 2 days ago
$364
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $364 found 2 days ago
Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$370 Roundtrip, found 2 days ago
$370
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $370 found 2 days ago
Alaska Airlines
Tue, Mar 3 - Wed, Mar 11
MFR
Medford
ZLO
Manzanillo
$374 Roundtrip, found 2 days ago
$374
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Tue, Mar 3 from Medford to Manzanillo, returning Wed, Mar 11, priced at $374 found 2 days ago
Hawaiian Airlines
Fri, Jan 2 - Wed, Jan 14
MFR
Medford
ZLO
Manzanillo
$380 Roundtrip, found 6 days ago
$380
Roundtrip
found 6 days ago
Select Hawaiian Airlines flight, departing Fri, Jan 2 from Medford to Manzanillo, returning Wed, Jan 14, priced at $380 found 6 days ago
Delta
Sun, Jan 25 - Wed, Feb 4
MFR
Medford
ZLO
Manzanillo
$400 Roundtrip, found 6 days ago
$400
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Jan 25 from Medford to Manzanillo, returning Wed, Feb 4, priced at $400 found 6 days ago
United
Tue, Mar 17 - Wed, Mar 25
MFR
Medford
ZLO
Manzanillo
$530 Roundtrip, found 1 day ago
$530
Roundtrip
found 1 day ago
Select United flight, departing Tue, Mar 17 from Medford to Manzanillo, returning Wed, Mar 25, priced at $530 found 1 day ago
Aeromexico
Wed, Dec 31 - Fri, Jan 16
MFR
Medford
ZLO
Manzanillo
$593 Roundtrip, found 6 days ago
$593
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Wed, Dec 31 from Medford to Manzanillo, returning Fri, Jan 16, priced at $593 found 6 days ago

Alternative airports near Manzanillo

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Playa de Oro Intl. ZLO. Cheapest and Closest option available. Average driving time to city center is 42 minutes. Flights from $758
ZLO
Playa de Oro Intl.
CheapestClosest
Average driving time to city center42 min
Flights from $758
Flights from Medford (MFR) to Manzanillo (ZLO)
Origin airport
Rogue Valley Intl.
Destination airport
Playa de Oro Intl.
Airlines serving
Aeromexico, Alaska Airlines, American Airlines, Delta, Hawaiian Airlines, United
Roundtrip price
$346
Distance
1928 mi

Medford to Manzanillo Flights

The cheapest times to fly from Medford to Manzanillo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medford to Manzanillo are during the month of March. You can find some of the cheapest flights from Medford to Manzanillo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medford to Manzanillo

Sunday is one of the best days to book for cheap flights from Medford to Manzanillo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medford to Manzanillo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medford to Manzanillo in 2026. You can also book with separate airlines for your outbound and return journeys, from $155 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medford to Manzanillo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medford to Manzanillo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO) cost?
Get a cheap one-way flight from $155 or cheap return flight from $346 from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO)?
Flying in March can help you save, as it's the cheapest month for flights between MFR and ZLO. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO)?
To find the cheapest airline flying from MFR to ZLO, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to see the cheapest flights first.
How many flights per day from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO)?
You'll need to hop on a flight with a layover when traveling from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO). There are no daily direct flights on this route. However, simply filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from MFR to ZLO?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO)?
To touch down at Playa de Oro Intl. Airport (ZLO) on time, book a flight that leaves Rogue Valley Intl. Airport (MFR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO) last-minute?
Last-minute fares from MFR to ZLO are typically more expensive. To lock in the lowest prices, start searching for flights well ahead of time. That said, if you're flexible with your travel dates, you may score a cheap ticket right before your journey.
Is it cheaper to book a MFR to ZLO flight and hotel package?
You'll typically save money by securing a MFR to ZLO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've chosen your ideal flights and accommodations, consider adding extras including car rentals, tours and activities.
Can I cancel or change the date of my flight from Rogue Valley Intl. Airport (MFR) to Playa de Oro Intl. Airport (ZLO)?
If you booked your MFR to ZLO flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.

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*Available to One Key members.