$508 Cheap Flights from Myrtle Beach (MYR) to Southampton (SOU)

View $508 flight on Sat, Sep 26, 2026Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Southampton (SOU)

Cheap Flights from Myrtle Beach to Southampton (MYR-SOU)

Prices were available within the past 7 days and start at $508 for one-way flights and $1,008 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,008 Roundtrip, found 15 hours ago
$1,008
Roundtrip
found 15 hours ago
Select Delta flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,008 found 15 hours ago
Delta
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,014 Roundtrip, found 15 hours ago
$1,014
Roundtrip
found 15 hours ago
Select Delta flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,014 found 15 hours ago
Delta
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,015 Roundtrip, found 15 hours ago
$1,015
Roundtrip
found 15 hours ago
Select Delta flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,015 found 15 hours ago
American Airlines
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,018 Roundtrip, found 15 hours ago
$1,018
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,018 found 15 hours ago
KLM
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,020 Roundtrip, found 15 hours ago
$1,020
Roundtrip
found 15 hours ago
Select KLM flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,020 found 15 hours ago
KLM
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,021 Roundtrip, found 15 hours ago
$1,021
Roundtrip
found 15 hours ago
Select KLM flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,021 found 15 hours ago
American Airlines
Thu, Dec 4 - Fri, Dec 12
MYR
Myrtle Beach
SOU
Southampton
$1,024 Roundtrip, found 15 hours ago
$1,024
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Thu, Dec 4 from Myrtle Beach to Southampton, returning Fri, Dec 12, priced at $1,024 found 15 hours ago

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU) cost?
Grab a cheap one-way flight from $508 or cheap return flight from $1,008 from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU)?
The cheapest month to fly from MYR to SOU is December, when there's less demand. Off-peak months are generally when airlines offer better prices between these airports.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU)?
To find the cheapest airline flying from MYR to SOU, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU)?
There aren't any daily direct flights available from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from MYR to SOU?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU)?
To reach Southampton Airport (SOU) on schedule, choose a flight that takes off from Myrtle Beach Intl. Airport (MYR) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU) last-minute?
Booking your ticket from MYR to SOU right before your journey is generally more expensive. But if there's some wiggle room with your schedule, you could bag a cheap last-minute fare.
Is it cheaper to book a MYR to SOU flight and hotel package?
You'll generally save money by booking a MYR to SOU flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one convenient place. Once you've chosen your ideal accommodations and flights, consider adding extras including activities, tours and car rentals.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Southampton Airport (SOU)?
Generally, it's possible to reschedule or cancel your MYR to SOU flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Southampton
Airlines serving
KLM
Roundtrip price
$1,008
Distance
3943 mi

Book with confidence

Myrtle Beach to Southampton Flights

The cheapest times to fly from Myrtle Beach to Southampton

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Southampton are during the month of December. You can find some of the cheapest flights from Myrtle Beach to Southampton with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Southampton

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Southampton: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Southampton

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Southampton in 2025. You can also book with separate airlines for your outbound and return journeys, from $508 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Southampton flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Southampton airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Southampton Flights

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*Available to One Key members.