$221 Cheap Flights from Uyuni (UYU) to Santa Cruz (VVI)

View $221 flight on Mon, Nov 10, 2025Opens in a new window

Popular airlines from Uyuni (UYU) to Santa Cruz (VVI-Viru Viru Intl.)

Cheap Flights from Uyuni to Santa Cruz (UYU-VVI)

Prices were available within the past 7 days and start at $221 for one-way flights and $469 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Boliviana De Aviacion
Sun, Nov 2 - Tue, Nov 4
UYU
Uyuni
VVI
Santa Cruz
$469 Roundtrip, found 1 day ago
$469
Roundtrip
found 1 day ago
Select Boliviana De Aviacion flight, departing Sun, Nov 2 from Uyuni to Santa Cruz, returning Tue, Nov 4, priced at $469 found 1 day ago
Boliviana De Aviacion
Sun, Nov 2 - Tue, Nov 4
UYU
Uyuni
VVI
Santa Cruz
$497 Roundtrip, found 1 day ago
$497
Roundtrip
found 1 day ago
Select Boliviana De Aviacion flight, departing Sun, Nov 2 from Uyuni to Santa Cruz, returning Tue, Nov 4, priced at $497 found 1 day ago

Frequently asked questions

How much does a flight from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI) cost?
Grab a cheap one-way flight from $221 or cheap return flight from $469 from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI)?
The cheapest month to fly from UYU to VVI is November, when demand is low. Off-peak season is typically when better flight deals are available between these airports.
What is the cheapest airline that flies from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI)?
To find the cheapest airline flying from UYU to VVI, use Expedia's filter tool. Tailor your search based on your travel style, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI)?
Direct flights from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from UYU to VVI?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI)?
Book a flight from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI) last-minute?
Holding off until right before your break to book your flight from UYU to VVI generally means paying more. While it's possible to find some last-minute deals, they're not always guaranteed. Allow some flexibility in your schedule for the best chance of landing a bargain.
Is it cheaper to book an UYU to VVI flight and hotel package?
Compared with arranging hotels and flights separately, booking an UYU to VVI flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place takes the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then tailor your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Uyuni Airport (UYU) to Viru Viru Intl. Airport (VVI)?
It's generally possible to cancel or reschedule your UYU to VVI flight. However, if it's been more than 24 hours since booking, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more details on our Customer Service portal.

Travel information

Travel information

Origin airport
Uyuni
Destination airport
Viru Viru Intl.
Roundtrip price
$469
Distance
309 mi

Book with confidence

Book with confidence

Uyuni to Santa Cruz Flights

The cheapest times to fly from Uyuni to Santa Cruz

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Uyuni to Santa Cruz are during the month of November. You can find some of the cheapest flights from Uyuni to Santa Cruz with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Uyuni to Santa Cruz

Sunday is one of the best days to book for cheap flights from Uyuni to Santa Cruz: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Uyuni to Santa Cruz

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Uyuni to Santa Cruz in 2025. You can also book with separate airlines for your outbound and return journeys, from $221 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Uyuni to Santa Cruz flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Uyuni to Santa Cruz airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Uyuni to Santa Cruz Flights

Explore a world of travel with Expedia

Explore a world of travel with Expedia

*Available to One Key members.