St. Louis Luxury Vacations 2026

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Top Luxury vacation packages in St. Louis

Price found within the past 48 hours. Click for updated prices.

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Downtown St. Louis

$372

per person

Dec 17 - Dec 20

found 7 hours ago

Roundtrip flight included

Fort Lauderdale (FLL) to St. Louis (STL)

8.6/10 Excellent! (1,378 reviews)

I had a wonderful stay! There was a gentleman at the front desk and I believe his name was Lans. So helpful! He was such a gem to work with and completely took care of everything for me. Wood stay there again!

Reviewed on Oct 13, 2026

Four Seasons Hotel St Louis

Downtown St. Louis

$788

per person

Nov 13 - Nov 16

found 6 hours ago

Roundtrip flight included

Charlotte (CLT) to St. Louis (STL)

9.4/10 Exceptional! (1,002 reviews)

Excellent customer service

Reviewed on Oct 11, 2026

Ameristar Casino Resort and Spa

$412

per person

Dec 14 - Dec 16

found 1 day ago

Roundtrip non-stop flight included

Portland (PDX) to St. Louis (STL)

8.6/10 Excellent! (1,062 reviews)

Wonderful stay for a small bachelorette party. Had a wonderful time!

Reviewed on Oct 10, 2026

Moonrise Hotel

Delmar Loop

$392

per person

Dec 14 - Dec 16

found 1 day ago

Roundtrip non-stop flight included

Portland (PDX) to St. Louis (STL)

9/10 Wonderful! (2,029 reviews)

I slept well.

Reviewed on Oct 13, 2026

Marriott St. Louis Airport

Edmundson

$380

per person

Dec 14 - Dec 16

found 1 day ago

Roundtrip non-stop flight included

Portland (PDX) to St. Louis (STL)

8/10 Very Good! (1,001 reviews)

n/a

Reviewed on Oct 9, 2026

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5* Luxury vacations in St. Louis

Price found within the past 48 hours. Click for updated prices.

Four Seasons Hotel St Louis

Downtown St. Louis

$788

per person

Nov 13 - Nov 16

found 6 hours ago

Roundtrip flight included

Charlotte (CLT) to St. Louis (STL)

9.4/10 Exceptional! (1,002 reviews)

Excellent customer service

Reviewed on Oct 11, 2026

The Ritz-Carlton, St. Louis

Clayton

$1,411

per person

Dec 23 - Dec 26

just found

Roundtrip non-stop flight included

San Jose (SJC) to St. Louis (STL)

9.2/10 Wonderful! (586 reviews)

Don't eat at the restaurant. The food was awful. The service was horrible, maybe worst I've ever had. Couldn't get orders. Couldn't get refills. Server not once asked how the food or drinks were (they were awful as well). And it was an anniversary dinner for us and stay. Hotel pillows were horrible. The TV sucked (can't even airplay??) So much for a 5 star experience. Cheap and mediocre. Will never go back.

Reviewed on Sep 8, 2026

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3 Night Luxury vacations in St. Louis

Price found within the past 48 hours. Click for updated prices.

The Westin St. Louis

Downtown St. Louis

Save 100% on your flight

$280

per person

Nov 13 - Nov 16

found 14 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,012 reviews)

River City Casino & Hotel

$451

per person

Nov 13 - Nov 16

found 6 hours ago

Roundtrip flight included

Charlotte (CLT) to St. Louis (STL)

9/10 Wonderful! (1,808 reviews)

Our room was beautiful, comfortable and very clean. Personnel at the front desk was very friendly and helpful. Casino was on par with any Las Vegas casino.

Reviewed on Oct 13, 2026

Moonrise Hotel

Delmar Loop

Save 100% on your flight

$377

per person

Nov 13 - Nov 16

found 14 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9/10 Wonderful! (2,029 reviews)

I slept well.

Reviewed on Oct 13, 2026

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4 Night Luxury vacations in St. Louis

Price found within the past 48 hours. Click for updated prices.

Clayton Plaza Hotel & Extended Stay

Clayton

$521

per person

Nov 19 - Nov 23

found 5 hours ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

8.8/10 Excellent! (3,451 reviews)

Hotel staff were excellent, friendly, professional and by far the best reason to re-book. The hotel itself was very clean, located near professional buildings/courts and some eateries within walking distance. The room was clean as well and nicely proportioned with some of the best mattresses/bedding I've experienced. Only slight downside was the breakfast bar--the food and choices were ample and very good (especially the made to order omelets and waffles) but the setting was less than clean and rather worn--not in keeping with the rest of the hotel. All in all, a great place to stay and would definitely book again.

Reviewed on Oct 13, 2026

The Wildwood Hotel

$618

per person

Nov 24 - Nov 28

found 1 day ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

9.2/10 Wonderful! (1,679 reviews)

Homewood Suites by Hilton St Louis - Galleria

Clayton

$585

per person

Nov 19 - Nov 23

found 5 hours ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

7.8/10 Good! (1,005 reviews)

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What can I expect from a luxury St. Louis vacation?

Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury St. Louis vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. 

How can I find all-inclusive luxury vacation packages in St. Louis?

By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger. 

Can I book a cheap St. Louis luxury vacation?

Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $280. Prices and availability are subject to change. Additional terms may apply.

How can I book a luxury family vacation in St. Louis?

Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. 

Can I book a package in St. Louis with a luxury vacation home?

A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.   

How can I find the best luxury vacation deals in St. Louis?

Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.

Can I book a luxury holiday in St. Louis with free cancellation and/or flexible dates?

Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. 

Why should I book my luxury trip to St. Louis with Expedia?

A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.

Top Luxury St. Louis Hotels

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO

6 min drive from St. Louis Union Station

Treat yourself to some luxurious accommodations at The Royal Sonesta Chase Park Plaza St. Louis, where you can enjoy amenities like pillowtop beds, designer ...

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

34 min drive from St. Louis Union Station

Stay in the lap of luxury at Ameristar Casino Resort and Spa, where you can enjoy amenities like plush bedding, HDTVs, and more. Notable amenities include a ...

8.6/10 Excellent! (1,069 reviews)

"Wonderful stay for a small bachelorette party. Had a wonderful time!"

Reviewed on Oct 10, 2026

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO

13 min drive from St. Louis Union Station

Be treated to a luxury stay at The Ritz-Carlton, St. Louis, where you can enjoy amenities like plush bedding, designer toiletries, and more. The 3 bars, fitness ...

9.2/10 Wonderful! (586 reviews)

"Don't eat at the restaurant. The food was awful. The service was horrible, maybe worst I've ever had. Couldn't get orders. Couldn't get refills. Server not once asked how the food or drinks were (they were awful as well). And it was an anniversary dinner for us and stay. Hotel pillows were horrible. ..."

Reviewed on Sep 8, 2026

See all 1,937 properties in St. Louis

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.