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Depew Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Depew vacation rentals

A spacious living room with a wooden dining table, a sofa, a coffee table, and a TV mounted on the wall.

1. Luxury Villa

Luxury Villa
Lancaster
9.6 out of 10, Exceptional, (29 reviews)
"A wonderful place to stay. We wish we could have been able to enjoy it more than just our quick 1 night stay. It was very comfortable and nice."
United States
Scott C.
$160 nightly
The price is $179
Nov 5 - Nov 6
Total with taxes and fees
Luxury Villa
A modern kitchen with white cabinets, a marble island, and pendant lighting.

2. Como Lake Park Retreat | Hot Tub + Designer Home

Como Lake Park Retreat | Hot Tub + Designer Home
Lancaster
10.0 out of 10, Exceptional, (1 review)
"Amazing stay in a great location! Everything about our stay was wonderful. My husband especially loved the massage chair, it was definitely the highlight of our Buffalo trip! Everyone enjoyed the incredibly comfortable beds, soft and absorbent towels, and relaxing hot tub.Keith was a fantastic host and was wonderful and prompt with his communication. We truly couldn’t have asked for a better experience.I highly recommend this rental to anyone visiting the Buffalo area, and I would personally...
United States
Fanny C.
$331 nightly
The price is $334
Nov 19 - Nov 20
Total with taxes and fees
Como Lake Park Retreat | Hot Tub + Designer Home
A living room with a dark brown sofa, a patterned rug, and a red patterned ottoman. There is a kitchen area in the background with a refrigerator and a bar counter.

3. Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!

Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!
Buffalo
9.8 out of 10, Exceptional, (53 reviews)
"Pet friendly with easy access to Buffalo, Niagara Falls, Darien Lake, the airport and the mall. Great home base for a few days in the area."
United States
Paul
$201 nightly
The price is $231
Nov 5 - Nov 6
Total with taxes and fees
Niagara Falls is only 30minutes away.Airport 4 min away. Family & pet friendly!
A spacious kitchen with a granite countertop, white cabinetry, and a large island with a sink. There is a chandelier, a television, and a dining area visible.

4. *Perfect Vacation* Cozy Lancaster Village Bungalow

*Perfect Vacation* Cozy Lancaster Village Bungalow
Lancaster
10.0 out of 10, Exceptional, (1 review)
"No concerns. Everything as stated. "
United States
Ronald F.
$328 nightly
The price is $331
Nov 5 - Nov 6
Total with taxes and fees
*Perfect Vacation* Cozy Lancaster Village Bungalow
A modern living room with a wooden wall, a flat-screen TV, a round coffee table, and a sofa with cushions.

5. *Central location*Clean*Parking*2BDRM*A/C

*Central location*Clean*Parking*2BDRM*A/C
Cheektowaga
10.0 out of 10, Exceptional, (4 reviews)
"Loved it"
United States
Mara R.
$247 nightly
The price is $250
Nov 5 - Nov 6
Total with taxes and fees
*Central location*Clean*Parking*2BDRM*A/C
A covered outdoor patio with a fire feature, seating, and a table.

6. Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls

Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls
Depew
10.0 out of 10, Exceptional, (54 reviews)
"Very satisfied with the overall experience of my stay, Chad was very kind and helpful with info. Communication from booking to leaving. I would definitely recommend staying here if anyone visiting the buffalo area."
United States
Jodhan B.
$461 nightly
The price is $528
Nov 8 - Nov 9
Total with taxes and fees
Spacious/Comfy/Private Home near Buffalo/Bills/Airport/Niagara Falls
A coffee station with a coffee maker, sugar, creamer, and coffee beans.

7. 11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!

11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!
Buffalo
9.8 out of 10, Exceptional, (12 reviews)
"Very clean and accomadating"
United States
Francis c.
$188 nightly
The price is $210
Nov 5 - Nov 6
Total with taxes and fees
11 min from BUF Airport, 19 min from Bills Stadium, 35 min from Niagara Falls!
A living room with a sofa set, a coffee table, a TV, a lamp, and a fireplace.

8. Nice big house with parking, fenced yard

Nice big house with parking, fenced yard
Buffalo
7.8 out of 10, Good, (9 reviews)
"Great place"
United States
JOSEPH Z.
$287 nightly
The price is $341
Nov 10 - Nov 11
Total with taxes and fees
Nice big house with parking, fenced yard
A living room with a fireplace, grey sofas, a TV, and a coffee table.

9. King bed fenced backyard and parking

King bed fenced backyard and parking
Buffalo
9.4 out of 10, Exceptional, (3 reviews)
"We were in town for our daughter’s college graduation and the house was perfect. Great landing place, clean, had the basics, enough space for all. "
United States
Deb G.
$345 nightly
The price is $412
Nov 19 - Nov 20
Total with taxes and fees
King bed fenced backyard and parking
A modern living room with a sofa set, a large mirror, and a door leading to another room.

10. Sweet home, King bed, fenced backyard, and parking

Sweet home, King bed, fenced backyard, and parking
Buffalo
10.0 out of 10, Exceptional, (1 review)
"The house was located in a quiet older neighborhood. Perfect location for exploring around Buffalo and Niagara Falls. The fenced in yard is perfect for pets. There are ample sleeping places for family/friends. Each bedroom has a big-screen TV and either a floor fan, ceiling fan, or a/c. The house has clearly been updated recently. The bathrooms are nice and clean, the kitchen was also nicely done, and there is new flooring throughout the entire house. There are plenty of...
United States
Cassie J.
$348 nightly
The price is $405
Nov 9 - Nov 10
Total with taxes and fees
Sweet home, King bed, fenced backyard, and parking
A modern living room with a sofa, a coffee table, and a TV. There is a mirror on the wall and a door leading to another room.

11. Spacious 3BR Home | Recently Remodeled | Private Yard & Parking

Spacious 3BR Home | Recently Remodeled | Private Yard & Parking
West Seneca
9.0 out of 10, Wonderful, (12 reviews)
"Yes suitable for pets. Kitchen had what we needed. We very much enjoyed our stay, immaculate condition. "
United States
Sean
$273 nightly
The price is $325
Nov 16 - Nov 17
Total with taxes and fees
Spacious 3BR Home | Recently Remodeled | Private Yard & Parking
A modern living room with a sofa, armchair, and coffee table. There is a flat-screen TV mounted on the wall.

12. Your Cozy Home Away From Home king bed, parking

Your Cozy Home Away From Home king bed, parking
West Seneca
8.0 out of 10, Very good, (3 reviews)
"We staying here for a concert at Highmark"
United States
Jay M.
$249 nightly
The price is $297
Dec 1 - Dec 2
Total with taxes and fees
Your Cozy Home Away From Home king bed, parking
A modern living room with a sectional sofa, a coffee table, and a patterned rug.

13. Spacious 4BR Home near Buffalo and Niagara Falls, Sleeps 8

Spacious 4BR Home near Buffalo and Niagara Falls, Sleeps 8
Lancaster
$701 nightly
The price is $783
Nov 8 - Nov 9
Total with taxes and fees
Spacious 4BR Home near Buffalo and Niagara Falls, Sleeps 8
A bedroom with a bed, dresser, and a television.

14. Peaceful one bedroom in university district

Peaceful one bedroom in university district
University Heights
8.8 out of 10, Excellent, (6 reviews)
"Very clean, basic studio apt. Excellent communication from owner. Good location"
United States
Ben
$147 nightly
The price is $169
Nov 5 - Nov 6
Total with taxes and fees
Peaceful one bedroom in university district
A spacious living room with a leather sofa, teal armchairs, a glass coffee table, and a television.

15. The Victorian on South Park • Sleeps 6

The Victorian on South Park • Sleeps 6
Triangle
9.0 out of 10, Wonderful, (27 reviews)
"This place had everything we needed and the host was responsive."
United States
Sara S.
$177 nightly
The price is $203
Nov 5 - Nov 6
Total with taxes and fees
The Victorian on South Park • Sleeps 6
A living room with a grey sofa, a coffee table, and a television. There is a window with curtains, a painting on the wall, and a vase with flowers on a side table.

16. Cozy 3BR Lower Unit home in South Buffalo Near Downtown

Cozy 3BR Lower Unit home in South Buffalo Near Downtown
South Park
9.4 out of 10, Exceptional, (3 reviews)
"Wonderful location, comfortable beds, spacious, coming back to Buffalo, we will stay here again."
United States
Maddie M.
$263 nightly
The price is $302
Dec 1 - Dec 2
Total with taxes and fees
Cozy 3BR Lower Unit home in South Buffalo Near Downtown
A kitchen with a stove, oven, and a ladder leading to a loft area.

17. Tiny Spa Cottage Retreat

Tiny Spa Cottage Retreat
Alden
9.8 out of 10, Exceptional, (147 reviews)
"Me and my girlfriend wanted a place to stay for the Bryson tiller concert and we couldn’t have chose a better place, the communication between me and host was great and they were very welcoming!!"
United States
Daniel
$174 nightly
The price is $194
Nov 10 - Nov 11
Total with taxes and fees
Tiny Spa Cottage Retreat
A bedroom with a bed, a TV on a stand, a dresser, and a framed picture on the wall.

18. 4 bedrooms & 3 bathrooms | Entire Home For Families 🏠

4 bedrooms & 3 bathrooms | Entire Home For Families 🏠
Buffalo
9.6 out of 10, Exceptional, (74 reviews)
"Place was great, clean and perfectly located for our needs. Plenty of parking. Host was great."
United States
Joe C.
$308 nightly
The price is $353
Nov 5 - Nov 6
Total with taxes and fees
4 bedrooms & 3 bathrooms | Entire Home For Families 🏠
A corner room with a curved wall, large windows, and a wooden floor.

19. Cozy 3-bedroom house in charming Buffalo with WiFi, AC

Cozy 3-bedroom house in charming Buffalo with WiFi, AC
Kaisertown
8.4 out of 10, Very good, (19 reviews)
"Great place to stay"
United States
Cristian
$199 nightly
The price is $228
Dec 5 - Dec 6
Total with taxes and fees
Cozy 3-bedroom house in charming Buffalo with WiFi, AC
A dining room with a black table, blue upholstered chairs, and a matching bench.

20. 420 Friendly 3 bedroom upstairs apartment. Street parking only.

420 Friendly 3 bedroom upstairs apartment. Street parking only.
Seneca
9.4 out of 10, Exceptional, (76 reviews)
"great location, clean, spacious"
United States
MacKenzie G.
$195 nightly
The price is $202
Nov 5 - Nov 6
Total with taxes and fees
420 Friendly 3 bedroom upstairs apartment. Street parking only.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Depew Hotel Reviews

Best Western Buffalo Inn & Suites

Best Western Buffalo Inn & Suites

8/10 Good
"small but nice, clean rooms. helpful staff."
Katherine 2-night trip
Posted 2 hours ago
Best Western Buffalo Inn & Suites

Find out more about Depew

Everything you need to know about Depew vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Depew vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Depew vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Depew vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Depew. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Depew in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $107 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Depew rentals

At Expedia, we put the best Depew vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Depew rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Depew vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Depew. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Depew?

Yes, we have vacation rentals near well known sights in Depew, or you can choose a secluded option if you're looking for relaxation. Depew is known for its shopping and restaurants. Make sure you have time to check out the sporting events and waterfalls during your trip.

What are some of the best vacation home rentals in Depew?

HTR Niagara: Visitors like this Depew vacation home rental. It is on the riverwalk and equipped with air-conditioning and free WiFi to help you feel perfectly comfortable in your new surroundings. Amenities like a coffee maker and free parking are also available for your convenience.

How many vacation rentals will I find in Depew?

Choose from 5 Expedia vacation rentals in Depew for a memorable vacation.

What can I see and do in Depew?

While exploring the area, visit family-friendly sights like Buffalo Museum of Science, or get outside and enjoy nature at Glen Falls. Highmark Stadium and Walden Galleria Mall are a couple of places you'll find in the larger area.

What are vacation rentals like in Depew?

Vacation rentals are private accommodations you can reserve for several days or more in Depew. Vacation rentals feature extras like WiFi and washers and dryers so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from shared hotel elevators and busy lobbies while still allowing you a great travel experience. You'll also find more space in a vacation rental than in a standard hotel, which makes a vacation rental a great option for a family trip.