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Our top choices for Depew hotels

Comfort Inn & Suites Niagara Falls Blvd USA

Comfort Inn & Suites Niagara Falls Blvd USA
2.5 star property
La Salle
8.8 out of 10, Excellent, (1399)
"Had a very nice stay! Would stay again!"
United States
Matt
$75 nightly
The price is $86
Jan 9 - Jan 10, 2026
Total with taxes and fees
Comfort Inn & Suites Niagara Falls Blvd USA

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG
2.5 star property
Buffalo
8.2 out of 10, Very Good, (1007)
"The staff were exceptional, the room was beautiful and clean, the location couldn’t be beat and it was in our price range!!"
United States
Jen
$95 nightly
The price is $108
Jan 5 - Jan 6, 2026
Total with taxes and fees
Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG

Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport
2.5 star property
Buffalo
8.0 out of 10, Very Good, (1911)
"Clean rooms, good and fresh breakfast, location."
Canada
Felipe
$84 nightly
The price is $96
Jan 15 - Jan 16, 2026
Total with taxes and fees
Sleep Inn & Suites Buffalo Airport

Buffalo Airport Hotel

Buffalo Airport Hotel
3.0 star property
Buffalo
8.0 out of 10, Very Good, (2794)
"Perfect for staying overnight !! "
United States
Lorena
$99 nightly
The price is $113
Dec 26 - Dec 27
Total with taxes and fees
Buffalo Airport Hotel

Hampton Inn Buffalo-Airport / Galleria Mall

Hampton Inn Buffalo-Airport / Galleria Mall
2.5 star property
Buffalo
8.6 out of 10, Excellent, (1000)
"Clean room, friendly staff and great location. "
Canada
Lisa
$108 nightly
The price is $123
Jan 23 - Jan 24, 2026
Total with taxes and fees
Hampton Inn Buffalo-Airport / Galleria Mall

La Quinta Inn & Suites by Wyndham Buffalo Amherst

La Quinta Inn & Suites by Wyndham Buffalo Amherst
3.0 star property
Buffalo
8.4 out of 10, Very Good, (1967)
"The hotel was great clean, accesable. quiet, close to UB"
United States
Bruce
$85 nightly
The price is $97
Jan 6 - Jan 7, 2026
Total with taxes and fees
La Quinta Inn & Suites by Wyndham Buffalo Amherst

Hampton Inn Buffalo-Hamburg

Hampton Inn Buffalo-Hamburg
2.5 star property
Hamburg
9.0 out of 10, Wonderful, (1002)
"Room was very clean and staff friendly"
United States
Peter
$99 nightly
The price is $113
Jan 20 - Jan 21, 2026
Total with taxes and fees
Hampton Inn Buffalo-Hamburg

Microtel Inn & Suites by Wyndham Niagara Falls

Microtel Inn & Suites by Wyndham Niagara Falls
2.5 star property
Niagara Falls
8.2 out of 10, Very Good, (1000)
"The staff friendly and the room was very clean and comfortable."
United States
Lin
$72 nightly
The price is $82
Dec 29 - Dec 30
Total with taxes and fees
Microtel Inn & Suites by Wyndham Niagara Falls

Red Roof Inn Buffalo - Niagara Airport

Red Roof Inn Buffalo - Niagara Airport
2.0 star property
Bowmansville
7.2 out of 10, Good, (1003)
"Loved every moment, clean, well affordable and the staff were amazing "
United States
Joselyin
$56 nightly
The price is $63
Dec 29 - Dec 30
Total with taxes and fees
Red Roof Inn Buffalo - Niagara Airport

DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst
4.0 star property
Buffalo
7.8 out of 10, Good, (1000)
"Everything look great we will come back again😀"
United States
Cheekeong
$85 nightly
The price is $97
Jan 6 - Jan 7, 2026
Total with taxes and fees
DoubleTree by Hilton Hotel Buffalo - Amherst

Comfort Inn & Suites Buffalo Airport

Comfort Inn & Suites Buffalo Airport
3.0 star property
Buffalo
8.2 out of 10, Very Good, (1271)
"Very nice stay"
United States
James
$97 nightly
The price is $110
Jan 8 - Jan 9, 2026
Total with taxes and fees
Comfort Inn & Suites Buffalo Airport

Comfort Inn & Suites Hamburg - Buffalo South

Comfort Inn & Suites Hamburg - Buffalo South
2.5 star property
Hamburg
7.4 out of 10, Good, (1000)
"I was pleasantly surprised by this hotel. It was clean, quiet, and breakfast was good."
United States
Cindy
$76 nightly
The price is $86
Jan 5 - Jan 6, 2026
Total with taxes and fees
Comfort Inn & Suites Hamburg - Buffalo South

Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG
2.5 star property
Grand Island
8.8 out of 10, Excellent, (1622)
"Clean room, amazing staff, good amenities.. Really enjoyed our family stay there..!"
Canada
Sriprakash
$87 nightly
The price is $99
Jan 4 - Jan 5, 2026
Total with taxes and fees
Holiday Inn Express Grand Island - Niagara Falls by IHG

Spark by Hilton Lockport

Spark by Hilton Lockport
3.0 star property
Lockport
7.4 out of 10, Good, (74)
"Great stay, thanks!"
Canada
Shirmilla
$69 nightly
The price is $78
Jan 1 - Jan 2, 2026
Total with taxes and fees
Spark by Hilton Lockport

Hampton Inn & Suites Buffalo Downtown

Hampton Inn & Suites Buffalo Downtown
2.5 star property
Downtown Buffalo
8.8 out of 10, Excellent, (1006)
"Hotel was very clean and the staff was friendly. My room was larger than expected. Breakfast was well stocked and had good variety. Great location also!"
United States
Holly
$133 nightly
The price is $155
Jan 20 - Jan 21, 2026
Total with taxes and fees
Hampton Inn & Suites Buffalo Downtown

La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport
3.0 star property
Buffalo
8.0 out of 10, Very Good, (1362)
"Always clean and friendly!"
Canada
Stacy
$76 nightly
The price is $86
Jan 18 - Jan 19, 2026
Total with taxes and fees
La Quinta Inn by Wyndham Buffalo Airport

Hampton Inn Buffalo - Amherst, NY

Hampton Inn Buffalo - Amherst, NY
2.5 star property
Buffalo
9.4 out of 10, Exceptional, (1994)
"Great room, staff, breakfast, and pool- would definitely stay here again!"
United States
Madison
$106 nightly
The price is $120
Jan 5 - Jan 6, 2026
Total with taxes and fees
Hampton Inn Buffalo - Amherst, NY

Econo Lodge Darien Lakes

Econo Lodge Darien Lakes
2.0 star property
Corfu
7.8 out of 10, Good, (805)
"Staff was really friendly!"
United States
Stephen
$69 nightly
The price is $76
Jan 18 - Jan 19, 2026
Total with taxes and fees
Econo Lodge Darien Lakes

Country Inn & Suites by Radisson, Buffalo South I-90, NY

Country Inn & Suites by Radisson, Buffalo South I-90, NY
2.5 star property
Buffalo
8.2 out of 10, Very Good, (1288)
"The breakfast was very good for a free hotel breakfast. And the staff was very pleasant. "
United States
Rhonda
$122 nightly
The price is $139
Jan 15 - Jan 16, 2026
Total with taxes and fees
Country Inn & Suites by Radisson, Buffalo South I-90, NY

Quality Inn Near Walden Galleria Mall

Quality Inn Near Walden Galleria Mall
2.5 star property
Buffalo
8.0 out of 10, Very Good, (1001)
"Friendly staff, easy parking"
United States
Brittany
$84 nightly
The price is $96
Dec 29 - Dec 30
Total with taxes and fees
Quality Inn Near Walden Galleria Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Depew Hotel Reviews

More cheap stays in Depew

Hotels in Depew with star-rating

Find out more about Depew

Top reasons to visit Depew

  • Family-Friendly Attractions: Depew offers a variety of activities perfect for families, including amusement parks and local theater.
  • Shopping Opportunities: Explore numerous shopping centers and malls for a fun retail experience.
  • Cultural Experiences: Visit urban parks, arts centers, and modern colleges that reflect Depew's vibrant community.
  • Charming Neighborhoods: Discover picturesque old mansions and enjoy budget-friendly excursions in welcoming surroundings.
  • Diverse Accommodations: Choose from a range of hotels, including pet-friendly and LGBTQIA welcoming options for a comfortable stay.

Find great hotels near Depew

Discover a variety of hotel accommodations in Depew, New York, perfect for every traveler. Whether you’re seeking a comfortable motel or a business-friendly hotel, you'll find options that cater to your needs. Enjoy pet-friendly environments and LGBTQIA welcoming spaces, ensuring a memorable vacation experience. Explore the best hotels and available options in Depew, and make your stay both enjoyable and convenient.

  • M Hotel Buffalo: M Hotel Buffalo is a welcoming 3.5-star hotel that offers a unique business-themed experience just 3 miles from Depew. This property is particularly friendly to the LGBTQIA community, making it an inclusive choice for travelers seeking a supportive environment. With a variety of business amenities, including a 24-hour accessible business center and meeting rooms, M Hotel Buffalo is ideal for those traveling for work. Guests can appreciate the hotel's modern decor and comfortable accommodations, ensuring a productive yet relaxing stay.
  • Country Inn & Suites by Radisson, Buffalo South I-90, NY: Located 6 miles from Depew, Country Inn & Suites by Radisson offers a blend of warmth and business-friendly amenities in a pet-friendly environment. This hotel caters to both business travelers and families, featuring a well-equipped business center, meeting rooms, and conference spaces. Its pet-friendly policy allows guests to bring their dogs and cats along, making it a great choice for those who don't want to leave their furry friends behind. The cozy atmosphere and convenient location enhance the overall guest experience.
  • Motel 6 Buffalo, NY - Airport - Williamsville: Situated just 3 miles from Depew, Motel 6 Buffalo is a budget-friendly option perfect for travelers seeking a casual and pet-friendly stay. This motel's policies allow pets at no additional fee, ensuring that guests can travel with their beloved animals without worry. The straightforward, no-frills accommodations provide all the essentials for a comfortable night’s rest. Whether you're in town for business or leisure, Motel 6 offers a convenient and affordable base for your Buffalo adventures.

Where to stay in Depew

Depew, New York, offers a delightful blend of family-friendly attractions and charming neighborhoods perfect for a city-themed getaway. Explore the nearby old mansions, enjoy budget-friendly excursions, and immerse yourself in a welcoming atmosphere. With its convenient location, Depew serves as an ideal base for discovering the rich culture of New York State, making it a great choice for families and business travelers alike.

  • Buffalo: As a bustling metropolis, Buffalo is the heartbeat of the region. Located adjacent to Depew, this city attracts travelers year-round, with peak visits in the summer months from June to August. Visitors come for family-friendly activities, business opportunities, and the vibrant city experience. Buffalo boasts an array of shopping centers and educational venues, while local landmarks include sports facilities and the picturesque national state park, perfect for outdoor enthusiasts. Don’t miss the opportunity to explore its rich cultural scene and diverse dining options.
  • Cheektowaga: Just 3 miles from Depew, Cheektowaga is a charming village that offers a variety of experiences for visitors. This destination sees consistent traffic year-round, with peaks in March to April and July. Known for its family-oriented atmosphere and business-friendly environment, Cheektowaga features shopping centers and educational institutions. Key attractions include modern colleges and sports facilities, making it a great spot for both leisure and learning. Enjoy the local dining options and community events that make this village unique.
  • Bowmansville: Located a mere 3 miles from Depew, Bowmansville is a vibrant city that welcomes visitors with its array of attractions. Peak travel occurs during the summer months of June to August, with additional activity in the fall. Visitors flock to Bowmansville for family-friendly fun, business opportunities, and city exploration. The area features shopping centers, an amusement park, and a theme park, ensuring entertainment for all ages. With its close-knit community vibe and numerous local events, Bowmansville is a delightful stop on your vacation journey.

Things to do near Depew

Depew, New York, is a great destination for families and business travelers alike, offering a variety of activities. Visitors can explore shopping centers and malls, enjoy the thrills of an amusement park, and experience local theater. With its blend of entertainment and shopping options, Depew provides a fun and engaging atmosphere for everyone looking to make lasting memories.

Shopping

For a great shopping experience in Depew, visit Walden Galleria Mall, just 3 miles away, offering a vibrant mix of entertainment and family-friendly options. Eastern Hills Mall, 5 miles away, also has a variety of shops. If you're up for a drive, check out Broadway Market, located 7 miles away.

Recreation

Diamond Hawk Golf Course offers a beautiful outdoor setting perfect for golf enthusiasts, with lush greens and a relaxed atmosphere. Holiday Twin Rinks provides an exciting ice skating experience, combining sports and entertainment. For a broader sports experience, visit the Northtown Center at Amherst, a premier sports facility.

Adventure

At Pole Position Raceway, located 3 miles from Depew, experience the thrill of indoor karting on a challenging track. For a scenic outdoor adventure, explore the Amherst Canalway Trail, situated 12 miles away, perfect for hiking and biking. Enjoy winter sports at Buffalo Ski Club, 15 miles away, featuring excellent skiing opportunities.

Nightlife

Experience the nightlife in Depew by catching a show at the nearby Lancaster Opera House or the University at Buffalo Center for the Arts for a dose of culture and romance. For those seeking adventure, Lasertron offers exciting arcade fun just a short drive away.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Depew

To save money on your trip to Depew, visit during the off-peak months of January to March when prices are lower, and consider staying on Tuesdays for the best hotel rates. Utilize Expedia’s search tool to filter by budget and eco-certified hotels. Combining your hotel, flights, and activities into a package can lead to significant savings. Join Expedia’s One Key membership for exclusive discounts and earn OneKeyCash for future bookings. Lastly, explore free activities in the area to enhance your experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Depew are January to March, where the prices are slightly lower. This is in comparison to July to September, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Depew is Tuesday. The most expensive day to stay in Depew is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred type of hotel. For instance, selecting the Eco-certified filter will showcase sustainable and environmentally friendly hotels that are currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your Depew hotel reservation with your flights and activities through an Expedia package.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Depew

Depew, New York, is a great destination for families and business travelers alike, offering a mix of cultural and urban experiences. Visitors can explore local attractions such as modern colleges, urban parks, and arts centers that reflect the area's vibrant community. Whether you're seeking a family outing or a city-themed adventure, Depew has something for everyone, along with nearby attractions to enhance your visit.

  • University At Buffalo - North Campus: Experience the vibrant energy of this modern university, located 8 miles from Depew. The campus features beautiful architecture and green spaces, perfect for a leisurely stroll or a picnic.
  • Shea's Performing Arts Center: Situated 9 miles away, this historic venue is renowned for its stunning design and rich cultural offerings. Catch a live show or take a guided tour to appreciate its artistic significance.
  • Roswell Park Cancer Institute: Located 8 miles from Depew, this institute not only focuses on innovative cancer research but also offers recreational facilities and a glimpse into its historic contributions to medicine.

Best time to go to Depew

The best time to visit Depew can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Depew falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature in Depew falls in January, visitor numbers are average and weather is very cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January25.0°F (-3.9°C)Light RainVery CloudyAverageSlightly Low
February25.9°F (-3.4°C)Light RainMostly CloudyAverageSlightly Low
March34.2°F (1.2°C)Light RainMostly CloudyAverageSlightly Low
April45.0°F (7.2°C)Light RainMostly CloudySlightly HighAverage
May57.6°F (14.2°C)Light RainMostly SunnyAverageAverage
June65.5°F (18.6°C)Light RainMostly SunnyAverageAverage
July71.1°F (21.7°C)Light RainMostly SunnySlightly HighSlightly High
August69.8°F (21.0°C)Light RainMostly SunnyAverageSlightly High
September63.5°F (17.5°C)Light RainMostly SunnySlightly HighSlightly High
October52.3°F (11.3°C)Light RainMostly CloudySlightly LowAverage
November40.5°F (4.7°C)Light RainMostly CloudySlightly LowAverage
December32.4°F (0.2°C)Light RainMostly CloudySlightly LowAverage

The nearest major airports for your trip to Depew

Depew, New York, is conveniently served by several airports, with Buffalo Niagara International Airport (BUF) being the closest at 3 miles away. Nearby hotel options include the 4-star Delavan Hotel & Spa and the Mosey Buffalo Williamsville, both just 2 miles from BUF, offering easy access to transportation services. For those considering Rochester, Greater Rochester International Airport (ROC) is 55 miles away, with quality accommodations like the DoubleTree by Hilton Rochester, located 4 miles from the airport. Additionally, Niagara Falls International Airport (IAG) is 18 miles from Depew, with nearby hotels such as Seneca Niagara Resort & Casino and Sheraton Niagara Falls, both 6 miles from IAG.

Frequently asked questions

What is the best area to stay in Depew?
For most visitors, the best area to stay in Depew is the vicinity surrounding the main commercial thoroughfares like Transit Road and Walden Avenue, particularly for its accessibility and convenience.

This area offers a concentration of hotels and amenities. You'll find a variety of dining options, from casual eateries to sit-down restaurants, along these main roads. Many hotels here are also near retail centers, making it easy to pick up any essentials. Families often find this location practical due to its straightforward access to local attractions and services.

Travelers looking for a convenient base for exploring the wider Buffalo area will appreciate hotels located near the I-90 expressway exits within Depew.
When is the best time to go to Depew?
The best time to go to Depew is during the summer months, from June to August, when the weather is warm and conducive to outdoor activities.

During this period, temperatures are generally pleasant, ranging from the mid-60s to high 70s Fahrenheit, making it ideal for exploring local parks or enjoying events in nearby Buffalo. The long daylight hours also allow for extended sightseeing and recreational opportunities.

Travelers looking to enjoy the region's natural beauty and outdoor attractions will find summer to be the most accommodating. This is a great time for families to visit, as they can take advantage of the warm weather for trips to amusement parks or nearby lakes without the concern of colder temperatures.

For those who prefer to avoid the peak tourist season but still want good weather, late spring (May) and early fall (September) also offer comfortable conditions with fewer crowds.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Depew.
How can I save on a Depew hotel booking with Expedia?
With Expedia, you earn OneKeyCash™* on eligible Depew hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Depew hotel?
Prices for hotels in Depew often vary, but you can find a great deal from $68 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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