Doe Run Vacations from $357

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Your Doe Run Vacation

Take the stress out of organizing your next big adventure with a Doe Run vacation package. Whether you're visiting for its history, food or something else, this city offers limitless opportunities for discovery. Looking for some sightseeing inspiration for your trip to Doe Run? St. Joe State Park and Crown Pointe Golf Club are two leading attractions here. Browse Expedia's wide range of travel options and start organizing your dream vacation to Doe Run today.

The Latest Doe Run vacation packages

Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

3 out of 5
Price was $369, price is now $357 per person
$357
per person
Sep 17 - Sep 19
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.4/10 Exceptional! (105 reviews)

The Mediterranean House 1858

The Mediterranean House 1858

2 out of 5
Price was $1,020, price is now $957 per person
$957
per person
Sep 17 - Sep 19
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
No reviews

Urban Lofts

Urban Lofts

3 out of 5
Price was $553, price is now $525 per person
$525
per person
Sep 17 - Sep 19
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.4/10 Exceptional! (22 reviews)
Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance.

Reviewed on Jun 11, 2026

Makanda Inn

Makanda Inn

3.5 out of 5
Price was $485, price is now $465 per person
$465
per person
Sep 17 - Sep 19
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
10/10 Exceptional! (38 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.

Reviewed on Jul 22, 2026

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel

2 out of 5
Price was $410, price is now $397 per person
$397
per person
Sep 17 - Sep 19
found 1 day ago
Roundtrip flight included
Orlando (MCO) to Cape Girardeau (CGI)
9.6/10 Exceptional! (4 reviews)
What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway.

Reviewed on Jun 13, 2026

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Doe Run Hotel Deals

16 Acres of beauty and relaxation

16 Acres of beauty and relaxation

Park Hills MO
9.8/10 Exceptional! (29 reviews)
"Fantastic place to relax! The cabin is located practically in the middle of the woods, which provides an amazing, peaceful atmosphere. I’ve been on many vacations in this area, but this is definitely one of the best cabins I have ever stayed in.Everything—both inside and outside—is absolutely perfect. ..."

Reviewed on Jul 12, 2026

Get rates
16 Acres of beauty and relaxation
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$58 nightly
The price is $63 total per night from Aug 9 to Aug 10
$63 total
Aug 9 - Aug 10
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!

Ste. Genevieve MO
$327 nightly
The price is $349 total per night from Jul 31 to Aug 1
$349 total
Jul 31 - Aug 1
Total with taxes and fees
10/10 Exceptional! (154 reviews)
"Our stay at the Silo House was absolutely wonderful! The home and surrounding property are stunning, and the peaceful setting made it the perfect escape from the hustle and bustle of everyday life. If you’re looking for a place to truly relax and recharge, this is it.My favorite part of the entire ..."

Reviewed on Jul 5, 2026

Silo Farm Haus- located in the heart of wine country!
See all 153 properties in Doe Run
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Doe Run Vacation Packages

Doe Run Essential Information

Language
English
Currency
U.S dollars
Population
920
Top Sights
Twin Oaks Vineyard & Winery, Sand Creek Winery and Crown Pointe Golf Club

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Frequently asked questions

How much does a Doe Run vacation package cost?
You can snap up a vacation package to this destination from $357 on Expedia. However, how much your vacation to Doe Run costs will depend on factors like your hotel choice, length of stay and season.
What are the cheapest months to go to Doe Run?
If you're looking to book a cheap Doe Run vacation package, consider planning a trip in February, September and December. You'll typically find better prices on airfares and hotels during these months — perfect for travelers wishing to save money.
How many days is enough for Doe Run?
Usually, a handful of days is enough to visit the top attractions during your Doe Run vacation. But if you prefer to have time to unwind or go on day tours, think about extending your itinerary.
How to find the best Doe Run package deals?
Begin your search for a Doe Run package deal by entering your destination and preferred travel dates under our "Packages" tab. Then add a few filters, like "Property type" and "Amenities," to fine-tune the results to your exact needs. You can also sort by "Package discount" and browse offers that come with irresistible savings. If you don't find the perfect Doe Run package deal straight away, simply play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Doe Run escape underway.
Is it cheaper to book a Doe Run vacation as a package?
An Expedia vacation package could land you great savings when compared to booking hotels and flights separately. Better still, you can personalize your Doe Run trip to match your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Doe Run?
If you've got your Doe Run vacation dates locked in, book early to grab some awesome deals. With Expedia, you can typically reserve some flights up to a year in advance. Prefer spur-of-the-moment getaways? Our last-minute deals are great for traveling on a whim.
Does Expedia offer Book Now, Pay Later Doe Run vacation packages?
Your Doe Run break should be an escape from your daily routine, not a reason for money-related stress. So to give you that extra flexibility, we've teamed up with online lender Affirm to offer you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and spread the total cost over 3, 6 or 12 months. Plus, there are no hidden costs or late payment fees to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.