Isla Santa María Vacations from $494

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Your Isla Santa María Vacation

Amazing adventures await when you reserve a vacation package to Isla Santa María. Whether you're a foodie, history buff or just a traveler who loves to experience new places, there's something for everyone in this lively city. Post Office Bay is one of the top attractions to include on your sightseeing agenda during a trip to Isla Santa María. Expedia is here to help you escape the everyday. Tailor your vacation to Isla Santa María to suit your travel style, whatever that may be.

The Latest Isla Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
BAY VIEW HOUSE

BAY VIEW HOUSE

3.5 out of 5
Price was $769, price is now $494 per person
$494
per person
Oct 6 - Oct 9
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
10/10 Exceptional! (2 reviews)
Hotel Albemarle Galapagos Beachfront

Hotel Albemarle Galapagos Beachfront

3.5 out of 5
Save 100% on your flight
Price was $997, price is now $677 per person
$677
per person
Oct 6 - Oct 9
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (86 reviews)
I really like this hotel, excellent location just by the beach, great breakfast and the employees very nice, polite and fantastic customer service also alot of restaurants very close. I will recommend all my family and friends to stay here.

Reviewed on Aug 27, 2025

Hotel Isamar Galapagos Beachfront

Hotel Isamar Galapagos Beachfront

3.5 out of 5
Price was $797, price is now $573 per person
$573
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (58 reviews)
We had a wonderful time! Breakfast was absolutely delicious, and we also enjoyed an amazing dinner during our stay. The cocktails were delicious and perfectly made. The staff provided excellent recommendations for things to do on Isabela Island, which really enhanced our experience. We truly appreciated the warm hospitality. The location right by the ocean was perfect, and everything was clean and well maintained. Highly recommended! Jenny , Pam and Rafael

Reviewed on Jul 22, 2025

La Casa de Marita

La Casa de Marita

3 out of 5
Price was $832, price is now $600 per person
$600
per person
Nov 21 - Nov 24
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to Isla Baltra (GPS)
9/10 Wonderful! (97 reviews)
We had a lovely night stay here. You’re on an island so some ants and bugs can be expected. This isn’t The Four Seasons so if you were looking for that you would be disappointed. What you will find staff willing to go above and beyond like Jonathan, who made our stay lovely. Love that you could just walk to the beach right behind the property. The peace and tranquillity you will find here is unmatched. I think this is the best place to stay on the island. We will definitely be returning.

Reviewed on May 14, 2025

Galapagos Sunset Hotel

Galapagos Sunset Hotel

3 out of 5
Price was $957, price is now $695 per person
$695
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip flight included
Guayaquil (GYE) to San Cristobal (SCY)
9.4/10 Exceptional! (158 reviews)
We loved our stay at this hotel. The staff was nice. Max at the front desk was SUPER helpful and pleasant. Aside from that, an excellent location to enjoy the best of San Cristóbal island has to offer. We didn't want to leave.

Reviewed on Aug 12, 2025

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See all available trips from Columbus to Isla Santa María
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Discover the most popular places to visit in Isla Santa María

Swimming with sea turtles was one of the many amazing moments of my Galapagos adventure. Like most of the other animals, they went about their business without seeming to even notice the people around.

Post Office Bay

Commune with nature and explore the great outdoors at Post Office Bay during your travels in Isla Santa María. While you're in the area, wander around the natural setting.

Post Office Bay
I've been spotted! A family of marine iguanas auditioning for meerkat manor #LifeAtExpedia

Punta Suarez

Explore the great outdoors at Punta Suarez, a lovely green space in Isla Santa María. Wander the seaside and white-sand beaches while you're in the area.

Punta Suarez

What to do in Isla Santa María

Learn about the history of Floreana

Full Day Floreana Tour

$220
per adult
Full Day Floreana Tour
Faune seeing at the snorkeling

Full Day Santa Fe & " Playa escondida" snorkeling tour

$220
per adult
Full Day Santa Fe & " Playa escondida" snorkeling tour
Galapagos Enchanting 3 Islands

Galapagos Enchanting 3 Islands (5 Days)

$1,086
per adult
Galapagos Enchanting 3 Islands (5 Days)
See all activities in Isla Santa María

Isla Santa María Hotel Deals

Hotel Fiesta

Hotel Fiesta

3.5 out of 5
Calle Moises Brito y Juan Montalvo, Puerto Ayora, Galapagos
$155 nightly
The price is $155 total per night from Sep 3 to Sep 4
$155 total
Sep 3 - Sep 4
Hotel Fiesta
Hotel el descanso del Guia

Hotel el descanso del Guia

3.5 out of 5
Calle Delfin, Barrio el Mirador, Puerto Ayora, Galapagos
Get rates
Hotel el descanso del Guia
Hotel Cucuve

Hotel Cucuve

4 out of 5
Charles Binford 083 y Ave Charles Darwin, Puerto Ayora
$180 nightly
The price is $200 total per night from Sep 29 to Sep 30
$200 total
Sep 29 - Sep 30
Hotel Cucuve
See all 197 properties in Isla Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does an Isla Santa María vacation package cost?
You can grab a vacation package to this top destination from $494 on Expedia. However, how much your vacation to Isla Santa María costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to Isla Santa María?
January, August and December are great times to search for cheap Isla Santa María vacation packages. Traveling in less busy months means you can typically find reduced prices on flights and hotels.
How many days is enough for Isla Santa María?
The ideal length of your Isla Santa María vacation depends on what you'd like to see. Usually, a handful of days to a week will give you time to check out all the top sights and explore some hidden treasures along the way.
How to find the best Isla Santa María package deals?
Start your search for an Isla Santa María package deal by entering your travel dates and destination under our "Packages" tab. Then select a few filters, like "Property type" and "Guest rating," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with big savings. If you don't find the perfect Isla Santa María package deal right away, simply change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Isla Santa Marían escape underway.
Is it cheaper to book an Isla Santa María vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll typically land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Isla Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Isla Santa María?
If you have your Isla Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to a year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are great for jetting off on a whim.
How to plan a trip to Isla Santa María?

  1. Choose your travel dates: What you want to do in Isla Santa Marían and your preferred season will help you decide when to travel.
  2. Set a budget: Factor in costs such as transportation, flights and meals when working out how much to put aside for your trip to Isla Santa María. Then, select a property that matches your budget, whether that's an affordable option or a lavish getaway.
  3. Organize your Isla Santa María getaway with Expedia's trip planning tool: Look for and book stays and things to do all in one place. You can also collaborate with family and friends to plan an unforgettable trip to Isla Santa María together.
  4. Decide your trip length: Think about how long you want to spend exploring Isla Santa María. Plan your days so you can get to all the attractions and experiences you're interested in at a leisurely pace.
  5. Bundle your flights and hotel: Awesome destination, check. Length of stay, check. All that's left now is to pick an Isla Santa María vacation package that brings all your bookings together.
  6. Add on experiences and excursions: Read our dedicated travel guide to find some incredible things to do in Isla Santa María. Book tickets or make reservations before you go to save time and skip the hassle of searching for activities once you arrive.

Does Expedia offer Book Now, Pay Later Isla Santa María vacation packages?
If you're like us, you love jet-setting around the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Isla Santa María trip across 3, 6 or 12 months. There are also no hidden or late payment fees, so you can snap up cheap vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.