Title: Panhandle Key Tours - Book Now | Expedia.com [Panhandle Key Hotels](https://expedia.com/Panhandle-Key-Hotels.0-l553248635975748450-0.Travel-Guide-Filter-Hotels)[Flights to Florida](https://expedia.com/Destinations-In-Florida.d211.Flight-Destinations)[Things to do in Florida](https://expedia.com/Things-To-Do-In-Florida.d211.Travel-Guide-Activities)[Car Rentals in Panhandle Key](https://expedia.com/Car-Rentals-In-Panhandle-Key.d553248635975748450.Car-Rental-Guide)[Florida Vacations](https://expedia.com/Florida.d211.Destination-Travel-Guides) # Panhandle Key Tours ## Visit Panhandle Key Activities --- --- ### Popular places to visit ![Hurricane Monument which includes a monument and outdoor art](https://images.trvl-media.com/place/6063543/461255cf-b7dd-46e6-b190-1a13cf74e1c5.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Hurricane Monument The memories of those lost to the 1935 Labor Day Hurricane live on at this moving tribute and burial site along the Overseas Highway. [](https://expedia.com/Hurricane-Monument-Matecumbe.d6063543.Vacation-Attraction) ![Islamorada_MatecumbeUnitedMethodistChurch_553248621532652347-0004](https://images.trvl-media.com/place/553248621532652347/4e16d0f0-6625-4d57-9e35-b8a011badc77.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Matecumbe United Methodist Church After visiting Matecumbe United Methodist Church, make a plan to see the other sights and activities in Islamorada. Discover the beautiful sunsets in this family-friendly area, or enjoy its fishing spots. [](https://expedia.com/Matecumbe-United-Methodist-Church-Matecumbe.d553248621532652347.Vacation-Attraction) ![Florida Keys Brewing Co. showing signage](https://images.trvl-media.com/place/553248635997958830/30b22f53-286f-436b-ae7a-d035c9062e6c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Florida Keys Brewing Co. You can take time to visit Florida Keys Brewing Co. during your travels to Islamorada. [](https://expedia.com/Florida-Keys-Brewing-Co-Matecumbe.d553248635997958830.Vacation-Attraction) ![Islamorada_BudnMarysDiveCenter_6069243-0004](https://images.trvl-media.com/place/6069243/da13ffdf-ddd2-4c35-bedc-c5b570b047e9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Bud n' Mary's Dive Center Explore the waterfront of Bud n' Mary's Dive Center and enjoy other activities such as fishing in Islamorada. Discover the beautiful sunsets and seafood restaurants in this family-friendly area. [](https://expedia.com/Bud-N-Marys-Dive-Center-Matecumbe.d6069243.Vacation-Attraction) ![History of Diving Museum showing heritage elements](https://images.trvl-media.com/place/6069257/3860ae1a-3cef-4809-8059-43794e9fe7f9.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### History of Diving Museum Trace one of the world’s most astonishing watersports back through the centuries to see some of the first diving suits as you explore this interactive museum, featuring the world's largest international collection of diving artifacts. [](https://expedia.com/History-Of-Diving-Museum-Matecumbe.d6069257.Vacation-Attraction) ![Theater of the Sea](https://images.trvl-media.com/place/6069249/5a39f3a2-0de6-49e9-a8f9-b4e8e17b70ba.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Theater of the Sea Swim with the dolphins and sharks and feed the crocodiles and sea turtles near the lagoon of this vast interactive park for marine mammals. [](https://expedia.com/Theater-Of-The-Sea-Islamorada.d6069249.Vacation-Attraction) --- ## Best Lodging Options Near Panhandle Key ## Check availability on hotels close to Panhandle Key [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=2026-03-25&endDate=2026-03-26)[Mar 25 - Mar 26](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=2026-03-25&endDate=2026-03-26) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=2026-03-26&endDate=2026-03-27)[Mar 26 - Mar 27](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=2026-03-26&endDate=2026-03-27) [This weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026)[Mar 27 - Mar 29](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=3%2F27%2F2026&endDate=3%2F29%2F2026) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026)[Apr 3 - Apr 5](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.Package&adults=2&openPlayBack=true®ionId=553248635975748450&startDate=4%2F3%2F2026&endDate=4%2F5%2F2026) ![Cheeca Lodge & Spa](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/4608d7e2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cheeca Lodge & Spa 81801 Overseas Highway, Mile Marker 82 Islamorada FL [](https://expedia.com/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Chesapeake Beach Resort](https://images.trvl-media.com/lodging/1000000/10000/4200/4170/689f4306_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Chesapeake Beach Resort 83409 Overseas Hwy Islamorada FL [](https://expedia.com/Islamorada-Hotels-Chesapeake-Beach-Resort.h4170.Hotel-Information) ![Amara Cay Resort](https://images.trvl-media.com/lodging/1000000/70000/62000/61976/4186365f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Amara Cay Resort 80001 Overseas Hwy Islamorada FL [](https://expedia.com/Islamorada-Hotels-Amara-Cay-Resort.h61976.Hotel-Information) ![Islander Resort](https://images.trvl-media.com/lodging/1000000/480000/475500/475438/f8d2863e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Islander Resort 82100 Overseas Highway Islamorada FL [](https://expedia.com/Islamorada-Hotels-Islander-Resort.h475438.Hotel-Information) ![La Siesta Resort & Villas](https://images.trvl-media.com/lodging/3000000/2480000/2477600/2477508/18023e21_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Siesta Resort & Villas 80241 Overseas Highway Islamorada FL [](https://expedia.com/Islamorada-Hotels-La-Siesta-Resort-Marina.h2477508.Hotel-Information) ![Sunset Inn](https://images.trvl-media.com/lodging/31000000/30570000/30568100/30568049/25606792_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sunset Inn 82200 Overseas Hwy Islamorada FL [](https://expedia.com/Islamorada-Hotels-Sunset-Inn.h30568049.Hotel-Information) ![Charming house boat with 2 bedrooms and WiFi, AC in wonderful Islamorada](https://images.trvl-media.com/lodging/117000000/116460000/116457600/116457585/4f804ccc_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Charming house boat with 2 bedrooms and WiFi, AC in wonderful Islamorada Islamorada FL [](https://expedia.com/Islamorada-Hotels-Charming-House-Boat-With-2-Bedrooms-And-WiFi.h116457585.Hotel-Information) ![Hadley Resort and Marina](https://images.trvl-media.com/lodging/1000000/20000/12200/12200/ed6e1255_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hadley Resort and Marina 82749 Overseas Hwy Islamorada FL [](https://expedia.com/Islamorada-Hotels-Hadley-House-Islamorada.h12200.Hotel-Information) ![La Jolla Resort](https://images.trvl-media.com/lodging/17000000/16580000/16574700/16574668/40f72f1c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Jolla Resort 82216 Overseas Highway Islamorada FL [](https://expedia.com/Islamorada-Hotels-La-Jolla-Resort.h16574668.Hotel-Information) [See all 1,065 properties in Panhandle Key](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=553248635975748450) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.