Southern Arizona, AZ

Travel Guide

A street with a theater, a Subway, and a building with a 'FOX' sign.
A vintage theater with a marquee reading "FOX" and a sign for "BEER & WINE" on the sidewalk.
A desert landscape with numerous cacti and mountains in the background.
A mountain with a small building in the foreground.
A large saguaro cactus with multiple arms against a sunset sky.

The iconic, cactus-lined deserts of Southern Arizona hark back to the days of the Old West, while the rest of the region offers trendy cities and lush vineyards.

Southern Arizona looks like a classic painting of American deserts. Drive through dusk-red plains lined with saguaro cacti and backed by dramatic rock formations. These familiar landscapes still manage to hide some surprises, including a thriving wine region and charming towns soaked in Americana.

Follow in the footsteps of Spanish conquistadors, who explored this land as early as the 1540s. Three centuries later, Southern Arizona boomed with the arrival of prospectors seeking copper and silver. Visit the Arizona History Museum to learn about Geronimo, the legendary Apache leader who fought in the Indian Wars of the late 19th century.

Stroll around artistic Tucson, which combines the Old West with modern, stylish Arizona. The Arizona-Sonora Desert Museum examines the landscapes of the region while the Old Tucson Studios have preserved atmospheric sets from old western movies. Don’t miss the Arizona State Museum and the University of Arizona Museum of Art.

Embrace the cowboy spirit of Tombstone, the town that was the home of Wyatt Earp. Listen to stories of outlaws and sheriffs at the informative museum in the Tombstone Courthouse. Nearby, colorful Bisbee is an old mining town with a welcoming, pedestrianized center lined with 19th-century homes.

Strike out into the wilderness yourself, taking plenty of water to explore these atmospheric deserts. Follow the Echo Canyon Loop Trail through the Chiricahua Mountains or drive out to Chiricahua National Monument, famed for its gravity-defying rock pillars. The geological wonders continue underground in breathtaking Kartchner Caverns State Park.

Sip on the delectable products of the Santa Cruz Valley, Southern Arizona’s very own wine country. Find tasting sessions and cellar tours in the vineyards that surround towns such as Sonoita and Elgin.

Board a flight from 19 destinations around America and Mexico to reach Tucson International Airport. Visit in winter for beautiful light in the empty desert regions or mild days in Tucson. Explore in spring and fall, when the weather doesn’t get too hot and the cacti are in bloom.

3 Palms Tucson North Foothills

3 Palms Tucson North Foothills

3 out of 5
7411 N Oracle Rd Tucson AZ
$52 nightly
The price is $59 total per night from Sep 27 to Sep 28
$59 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this family-friendly hotel in Tucson. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the pool and the helpful staff in ...
9.2/10 Wonderful! (7,103 reviews)
"I love it when I can find a one off motel that is both inexpensive and a great value. The 3 Palms is convenient and well maintained, and the rooms are comfortable and clean. Clearly they put a lot into making the stay far above their star rating. You can easily pay far more and get less elsewhere. ..."

Reviewed on Sep 23, 2026

3 Palms Tucson North Foothills
Westward Look Wyndham Grand Resort and Spa

Westward Look Wyndham Grand Resort and Spa

4 out of 5
245 E Ina Rd Tucson AZ
$177 nightly
The price is $202 total per night from Oct 4 to Oct 5
$202 total
Oct 4 - Oct 5
Total with taxes and fees
Book a stay at this spa resort in Tucson. Enjoy 3 outdoor pools, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Westward Look Wyndham Grand Resort and Spa
Hotel McCoy Tucson - Art, Coffee, Beer, Wine

Hotel McCoy Tucson - Art, Coffee, Beer, Wine

3 out of 5
720 W. Silverlake Road Tucson AZ
$80 nightly
The price is $92 total per night from Sep 28 to Sep 29
$92 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this family-friendly hotel in Tucson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. ...
Hotel McCoy Tucson - Art, Coffee, Beer, Wine
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Ventana Canyon Club and Lodge

Ventana Canyon Club and Lodge

4 out of 5
6200 N Club House Ln Tucson AZ
Book a stay at this spa aparthotel in Tucson. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff in our reviews. Popular ...
Ventana Canyon Club and Lodge
Flamingo Suites

Flamingo Suites

2.5 out of 5
401 W Lavery Ln Tucson AZ
Stay at this aparthotel in Tucson. Enjoy free WiFi, free parking, and laundry facilities. Popular attractions Tucson Mall and Tohono Chul Park are located ...
7.6/10 Good! (18 reviews)
"The room was spotless. Air-conditioning worked great. Shower pressure was great as well as temperature of the hot water. Close to everything."

Reviewed on Sep 14, 2026

Flamingo Suites
SaguaroGlamp

SaguaroGlamp

2 out of 5
20801 W Manville Rd Marana AZ
Stay at this campground in Marana. Enjoy free parking, breakfast (surcharge), and a garden.
9.8/10 Exceptional! (34 reviews)
"Very good."

Reviewed on Sep 7, 2026

SaguaroGlamp
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southern Arizona attractions

Things to do

Cities near Southern Arizona

Explore a world of travel with Expedia