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Find hotels in Southwest Illinois, IL from $59

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Compare 705 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Southwest Illinois hotels

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1439)
"Great place like a vacation every time I stay "
$94 nightly
The price is $106
Sep 7 - Sep 8
Total with taxes and fees
Drury Plaza Hotel Mt. Vernon

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
8.8 out of 10, Excellent, (853)
"The staff was friendly and very helpful."
$67 nightly
The price is $75
Sep 7 - Sep 8
Total with taxes and fees
SureStay Hotel by Best Western Whittington Rend Lake

Quality Inn & Suites Vandalia near I-70 and Hwy 51

2.5 star property
8.4 out of 10, Very Good, (1012)
"Will stay again."
$65 nightly
The price is $71
Sep 7 - Sep 8
Total with taxes and fees
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Comfort Suites Mount Vernon

2.5 star property
8.8 out of 10, Excellent, (1011)
"Nice hotel. Would stay here again."
$109 nightly
The price is $123
Aug 31 - Sep 1
Total with taxes and fees
Comfort Suites Mount Vernon

Holiday Inn Express & Suites Vandalia by IHG

2.5 star property
8.8 out of 10, Excellent, (733)
"Clean and right off the highway."
$116 nightly
The price is $126
Sep 3 - Sep 4
Total with taxes and fees
Holiday Inn Express & Suites Vandalia by IHG

Drury Inn & Suites Marion

3.0 star property
9.4 out of 10, Exceptional, (1009)
"We had an excellent stay."
$98 nightly
The price is $118
Sep 28 - Sep 29
Total with taxes and fees
Drury Inn & Suites Marion

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 star property
9.4 out of 10, Exceptional, (475)
"Rooms were clean and comfy, great breakfast "
$97 nightly
The price is $108
Sep 2 - Sep 3
Total with taxes and fees
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

The Principal Hotel

3.5 star property
9.8 out of 10, Exceptional, (125)
"Perfect stay! "
$113 nightly
The price is $125
Aug 31 - Sep 1
Total with taxes and fees
The Principal Hotel

Baymont by Wyndham Marion

2.5 star property
8.4 out of 10, Very Good, (1036)
"We stayed overnight for work and were very impressed with the hotel."
$85 nightly
The price is $102
Sep 3 - Sep 4
Total with taxes and fees
Baymont by Wyndham Marion

Best Western Marion Hotel

2.5 star property
8.2 out of 10, Very Good, (1008)
"Nice motel for a decent price."
$71 nightly
The price is $86
Sep 2 - Sep 3
Total with taxes and fees
Best Western Marion Hotel

Best Western Plus MidAmerica Hotel

2.5 star property
9.0 out of 10, Wonderful, (1010)
"Nice stay"
$112 nightly
The price is $124
Aug 31 - Sep 1
Total with taxes and fees
Best Western Plus MidAmerica Hotel

Comfort Inn & Suites Marion I-57

2.5 star property
9.2 out of 10, Wonderful, (1007)
"Very nice and clean, friendly staff, good breakfast too."
$113 nightly
The price is $135
Sep 14 - Sep 15
Total with taxes and fees
Comfort Inn & Suites Marion I-57

Comfort Inn & Suites Greenville I-70

2.5 star property
8.4 out of 10, Very Good, (398)
"good place to stay"
$94 nightly
The price is $105
Sep 21 - Sep 22
Total with taxes and fees
Comfort Inn & Suites Greenville I-70

Drury Inn & Suites St. Louis Collinsville

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Great place to stay "
$111 nightly
The price is $128
Sep 8 - Sep 9
Total with taxes and fees
Drury Inn & Suites St. Louis Collinsville

Best Western Plus Centralia Hotel & Suites

2.5 star property
9.6 out of 10, Exceptional, (568)
"Clean and kind staff!"
$139 nightly
The price is $156
Sep 1 - Sep 2
Total with taxes and fees
Best Western Plus Centralia Hotel & Suites

Drury Inn & Suites St. Louis Fairview Heights

3.0 star property
9.2 out of 10, Wonderful, (1012)
"Great stay! "
$93 nightly
The price is $106
Sep 11 - Sep 12
Total with taxes and fees
Drury Inn & Suites St. Louis Fairview Heights

Super 8 by Wyndham Greenville

2.0 star property
8.0 out of 10, Very Good, (728)
"It’s not super fancy, as you’d expect, but the place was decent and seemed clean, the staff was very friendly and helpful, and the prices are decent if you need a quick stay. "
$63 nightly
The price is $70
Sep 1 - Sep 2
Total with taxes and fees
Super 8 by Wyndham Greenville

Ramada by Wyndham Vandalia

2.0 star property
7.8 out of 10, Good, (786)
"It was clean and the bed was comfortable. Yhe pillows sucked though. "
$68 nightly
The price is $74
Sep 2 - Sep 3
Total with taxes and fees
Ramada by Wyndham Vandalia

Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

2.5 star property
8.8 out of 10, Excellent, (666)
"Great place to stay"
$114 nightly
The price is $129
Sep 12 - Sep 13
Total with taxes and fees
Fairfield Inn & Suites by Marriott Mt. Vernon Rend Lake

Baymont by Wyndham Chester IL

2.5 star property
8.6 out of 10, Excellent, (332)
"Quiet area with comfortable rooms and very helpful staff!"
$74 nightly
The price is $82
Sep 4 - Sep 5
Total with taxes and fees
Baymont by Wyndham Chester IL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Learn more about Southwest Illinois

Explore a “natural city” of trees, enjoy incredible hilltop views, marvel at geological wonders and hop between small towns in this beautiful region.

Southern Illinois which includes a lake or waterhole and forests
Photo by Southernmost Illinois Tourism Bureau
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Top Southwest Illinois Hotel Reviews

More cheap stays in Southwest Illinois

More cheap stays in Southwest Illinois

Hotels in Southwest Illinois with star-rating

Hotels in Southwest Illinois with star-rating

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