Texas Medical Center Vacations from $285
Book a Hotel + Flight or Car together to unlock savings
Your Texas Medical Center Vacation
Texas Medical Center is calling! Whatever type of break you're organizing, you can see and experience the best of this neighborhood with a Texas Medical Center vacation package. Your trip to Texas Medical Center wouldn't be complete without a stop at top attractions nearby such as Houston Zoo, Houston Natural Science Museum and Childrens Museum of Houston. Whatever your travel plans or the size of your budget, booking a perfect Texas Medical Center vacation is quick and easy with Expedia.
The Latest Texas Medical Center Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Margaritaville Lake Resort, Lake Conroe/Houston
Save 100% on your flight
Price was $700, price is now $440 per person
$440
per person
Feb 6 - Feb 9
found 16 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Houston (IAH)
16.4/10 Exceptional! (1,003 reviews)
Friendly and helpful staff. Clean rooms and grounds. Good atmosphere and food at the restaurants
Reviewed on Nov 15, 2025
The Residency Suites
Save 100% on your flight
Price was $503, price is now $321 per person
$321
per person
Dec 25 - Jan 1
found 18 hours ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
18/10 Exceptional! (225 reviews)
I didn't like the fact that they didn't provide toothpaste. Other than that I enjoined my stay. The room was spacious.
Reviewed on Apr 17, 2025
Palace Inn Blue Jones Rd
Save 100% on your flight
Price was $485, price is now $325 per person
$325
per person
Dec 25 - Jan 1
found 18 hours ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9/10 Wonderful! (93 reviews)
Staff was very friendly, the room was clean and comfortable, refrigerator was a bonus! Lots of walkable food and amenity options.
Reviewed on Jul 28, 2025
Where to stay in Texas Medical Center
Find the best Texas Medical Center areas and neighborhoods for the activities you enjoy most. Learn more about Texas Medical Center
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
Texas Medical Center Hotel Deals
Blossom Hotel Houston, Curio Collection by Hilton
7118 Bertner Ave Houston TX
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $154 total per night from Dec 15 to Dec 16
$154 total
Dec 15 - Dec 16
Total with taxes and fees
9/10 Wonderful! (3,551 reviews)
The best hotel in this area.
Reviewed on Nov 13, 2025
Hyatt Place Houston Medical Center
7329 FANNIN STREET Building 2 Houston TX
Fully refundableReserve now, pay when you stay
$130 nightly
The price is $152 total per night from Nov 23 to Nov 24
$152 total
Nov 23 - Nov 24
Total with taxes and fees
9/10 Wonderful! (2,124 reviews)
Clean room, breakfast and free shuttle to MD Anderson
Reviewed on Nov 12, 2025
Hilton Houston Plaza/Medical Center
6633 Travis St Houston TX
Fully refundableReserve now, pay when you stay
$85 nightly
The price is $100 total per night from Nov 30 to Dec 1
$100 total
Nov 30 - Dec 1
Total with taxes and fees
8.2/10 Very Good! (1,659 reviews)
All was good. The parking was not free. $20 to park.
Reviewed on Nov 10, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Texas Medical Center
MD Anderson Cancer Center
Though MD Anderson Cancer Center might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Texas Children's Hospital
Though Texas Children's Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Harris Health System - Ben Taub General Hospital
Though Harris Health System - Ben Taub General Hospital might be what brings you to town, perhaps you'll have a chance to explore more of Houston while you are here.
Things to do
Houston: Houston Botanic Garden Entry Ticket
$12
per adult
80% of travellers recommend
Houston Museum of Natural Science General Admission Ticket
$25
per adult
96% of travellers recommend
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
$25
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Houston Hotels
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- Houston Zoo
- MD Anderson Cancer Center
- Hermann Park
- Rice University
- Reckling Park
- Houston Vacations
- Rice Stadium
- Miller Outdoor Theater
- NRG Stadium
- Visit Astrodome
- James Turrell's Twilight Epiphany Skyscape
- Houston Natural Science Museum
- Houston Museum of Fine Arts
- NRG Park
- Houston Museum District Vacations
- Children's Museum of Houston
- Holocaust Museum Houston
- Cullen Sculpture Garden
- Visit Riverside Terrace
- Buffalo Soldiers National Museum
- Visit Houston Museum District
- Car rentals near Houston
- Car rentals near MD Anderson Cancer Center
- Standard Car Rentals near MD Anderson Cancer Center
- Car rentals near Houston Zoo
- Sportscar Car Rentals near Houston Zoo
- Car rentals near Hermann Park
- Car rentals near Rice University
- Pickup Car Rentals near Rice University
- SUV Car Rentals near Rice University
- Van Car Rentals near Rice University
- Car rentals near James Turrell's Twilight Epiphany Skyscape
- Car rentals near Houston Museum District
- Thrifty Car Rental Rental Cars in Houston Museum District
- Hertz Rental Cars in Houston Museum District
- Alamo Rent A Car Rental Cars in Houston Museum District
- Pickup Car Rentals in Houston Museum District
- Sixt Rental Cars in Houston Museum District
- Discount Quebec Rental Cars in Houston Museum District
- Budget Rental Cars in Houston Museum District
- Enterprise Rental Cars in Houston Museum District
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.