$133 Cheap American Airlines flights Charlotte (CLT) to Buffalo (BUF)

Finding cheap one-way American Airlines flights from CLT to BUF from $133 on Expedia is a cinch — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly return fares from $253 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for cheap American Airlines flights from Charlotte-Douglas Intl. Airport (CLT) to Buffalo Niagara Intl. Airport (BUF) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare type and itinerary, the ideal day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The earliest flight from CLT to BUF with American Airlines departs at 8:46AM UTC-5. You'll land at 10:38AM UTC-5. The final American Airlines flight of the day takes off at 10:29PM UTC-5 and arrives at 12:14AM UTC-5. With around 20% fewer cancellations for early and mid-morning departures, jetting out early is often the best option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.