$209 Cheap American Airlines flights Syracuse (SYR) to Minneapolis (MSP)

Use the "Price (lowest to highest)" filter on Expedia to find cheap American Airlines round-trip flights from $259 from SYR to MSP. Affordable one-way fares from $209 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find cheap American Airlines fares from Hancock Intl. Airport (SYR) to Minneapolis - St. Paul Intl. Airport (MSP), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also influence how much you pay. Sunday is usually the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departures from SYR to MSP with American Airlines, filter your results by "Early Morning" and "Morning." Booking an early flight usually means you're less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.