$428 Cheap LATAM Airlines Group flights San Francisco (SFO) to Santiago (SCL)

You can find budget-friendly return LATAM Airlines flights from $534 from SFO to SCL by sorting your results from "Price (lowest to highest)" on Expedia. Or look for options from $428 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Check for LATAM Airlines flights from SFO to SCL about one month before you want to leave. The most affordable time to reserve an international flight is usually 18 to 29 days ahead of your departure date when you can save 17% versus booking four to five months in advance. Regardless of itinerary or fare class, the best day to book international airfare is usually Sunday. Friday can be the most expensive. Travelers booking on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from SFO to SCL with LATAM Airlines, filter your results by "Morning" and "Early Morning." Booking an early flight generally means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.