$421 Cheap Flights from Denver (DEN) to Santiago (SCL)

View $421 flight on Tue, Mar 10, 2026Opens in a new window

Popular airlines from Denver Intl. Airport (DEN) to Santiago Intl. Airport (SCL)

Cheap Flights from Denver to Santiago (DEN-SCL)

Prices were available within the past 7 days and start at $421 for one-way flights and $532 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Apr 20 - Fri, May 15
DEN
Denver
SCL
Santiago
$532 Roundtrip, found 3 hours ago
$532
Roundtrip
found 3 hours ago
Select Copa flight, departing Mon, Apr 20 from Denver to Santiago, returning Fri, May 15, priced at $532 found 3 hours ago
United
Sun, Feb 8 - Fri, Feb 20
DEN
Denver
SCL
Santiago
$544 Roundtrip, found 3 days ago
$544
Roundtrip
found 3 days ago
Select United flight, departing Sun, Feb 8 from Denver to Santiago, returning Fri, Feb 20, priced at $544 found 3 days ago
Delta
Sun, Mar 15 - Sun, Mar 22
DEN
Denver
SCL
Santiago
$549 Roundtrip, found 7 hours ago
$549
Roundtrip
found 7 hours ago
Select Delta flight, departing Sun, Mar 15 from Denver to Santiago, returning Sun, Mar 22, priced at $549 found 7 hours ago
United
Thu, Feb 5 - Fri, Feb 13
DEN
Denver
SCL
Santiago
$552 Roundtrip, found 2 days ago
$552
Roundtrip
found 2 days ago
Select United flight, departing Thu, Feb 5 from Denver to Santiago, returning Fri, Feb 13, priced at $552 found 2 days ago
Delta
Sun, Mar 15 - Mon, Mar 23
DEN
Denver
SCL
Santiago
$554 Roundtrip, found 7 hours ago
$554
Roundtrip
found 7 hours ago
Select Delta flight, departing Sun, Mar 15 from Denver to Santiago, returning Mon, Mar 23, priced at $554 found 7 hours ago
Delta
Wed, Mar 11 - Sun, Mar 22
DEN
Denver
SCL
Santiago
$559 Roundtrip, found 7 hours ago
$559
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Mar 11 from Denver to Santiago, returning Sun, Mar 22, priced at $559 found 7 hours ago
United
Sun, Mar 8 - Sat, Mar 21
DEN
Denver
SCL
Santiago
$560 Roundtrip, found 2 days ago
$560
Roundtrip
found 2 days ago
Select United flight, departing Sun, Mar 8 from Denver to Santiago, returning Sat, Mar 21, priced at $560 found 2 days ago
United
Sat, Mar 7 - Mon, Mar 16
DEN
Denver
SCL
Santiago
$562 Roundtrip, found 2 days ago
$562
Roundtrip
found 2 days ago
Select United flight, departing Sat, Mar 7 from Denver to Santiago, returning Mon, Mar 16, priced at $562 found 2 days ago
LATAM Airlines Group
Fri, May 15 - Fri, May 22
DEN
Denver
SCL
Santiago
$564 Roundtrip, found 3 days ago
$564
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Fri, May 15 from Denver to Santiago, returning Fri, May 22, priced at $564 found 3 days ago
American Airlines
Sun, Jan 25 - Fri, Feb 13
DEN
Denver
SCL
Santiago
$564 Roundtrip, found 1 day ago
$564
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sun, Jan 25 from Denver to Santiago, returning Fri, Feb 13, priced at $564 found 1 day ago

Find the cheapest month to fly from Denver (DEN) to Santiago (SCL)

January is typically the cheapest month to fly

From $568 - $1,385 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $889
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $889
Flights from Denver (DEN) to Santiago (SCL)
Origin airport
Denver Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Aeromexico, Air Canada, American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$532
Distance
5503 mi

Denver to Santiago Flights

The cheapest times to fly from Denver to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Denver to Santiago are during the month of April. You can find some of the cheapest flights from Denver to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Denver to Santiago

Sunday is one of the best days to book for cheap flights from Denver to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Denver to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Denver to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $421 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Denver to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Denver to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL) cost?
Get a cheap one-way flight from $421 or cheap return flight from $532 from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL)?
April is the cheapest month to fly from DEN to SCL. Timing your trip outside of the busy season is often the key to finding better deals on flights.
What is the cheapest airline that flies from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL)?
To find the cheapest airline flying from DEN to SCL, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL)?
Direct flights from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and pick either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DEN to SCL?
Generally you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL)?
To avoid potential delays on the Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL) route, aim to travel before 3 PM. Departures after this hour have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from DEN to SCL just before your getaway is typically more expensive. But if there's some wiggle room with your departure times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a DEN to SCL flight and hotel package?
Booking a DEN to SCL flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Pick from our impressive range of accommodations and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Denver Intl. Airport (DEN) to Arturo Merino Benitez Airport (SCL)?
In most instances, you can reschedule or cancel your DEN to SCL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you want further details, visit our Customer Service portal.

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*Available to One Key members.