$148 Cheap Flights from Des Moines (DSM) to Buffalo (BUF)

View $148 flight on Thu, Oct 23, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)

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Cheap Flights from Des Moines to Buffalo (DSM-BUF)

Prices were available within the past 7 days and start at $148 for one-way flights and $297 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Oct 22 - Wed, Oct 29
DSM
Des Moines
BUF
Buffalo
$297 Roundtrip, found 2 days ago
$297
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 22 from Des Moines to Buffalo, returning Wed, Oct 29, priced at $297 found 2 days ago
American Airlines
Sat, Dec 6 - Tue, Dec 9
DSM
Des Moines
BUF
Buffalo
$305 Roundtrip, found 4 days ago
$305
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Dec 6 from Des Moines to Buffalo, returning Tue, Dec 9, priced at $305 found 4 days ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
BUF
Buffalo
$305 Roundtrip, found 4 days ago
$305
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 11 from Des Moines to Buffalo, returning Tue, Oct 14, priced at $305 found 4 days ago
Delta
Wed, Oct 22 - Fri, Oct 31
DSM
Des Moines
BUF
Buffalo
$307 Roundtrip, found 2 days ago
$307
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Oct 22 from Des Moines to Buffalo, returning Fri, Oct 31, priced at $307 found 2 days ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
BUF
Buffalo
$307 Roundtrip, found 4 days ago
$307
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Oct 11 from Des Moines to Buffalo, returning Tue, Oct 14, priced at $307 found 4 days ago
Delta
Sat, Nov 1 - Tue, Nov 4
DSM
Des Moines
BUF
Buffalo
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Nov 1 from Des Moines to Buffalo, returning Tue, Nov 4, priced at $310 found 4 days ago
United
Sat, Oct 11 - Tue, Oct 14
DSM
Des Moines
BUF
Buffalo
$310 Roundtrip, found 4 days ago
$310
Roundtrip
found 4 days ago
Select United flight, departing Sat, Oct 11 from Des Moines to Buffalo, returning Tue, Oct 14, priced at $310 found 4 days ago
Delta
Fri, Oct 31 - Tue, Nov 4
DSM
Des Moines
BUF
Buffalo
$311 Roundtrip, found 4 days ago
$311
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Oct 31 from Des Moines to Buffalo, returning Tue, Nov 4, priced at $311 found 4 days ago
United
Fri, Oct 31 - Tue, Nov 4
DSM
Des Moines
BUF
Buffalo
$312 Roundtrip, found 4 days ago
$312
Roundtrip
found 4 days ago
Select United flight, departing Fri, Oct 31 from Des Moines to Buffalo, returning Tue, Nov 4, priced at $312 found 4 days ago
Southwest Airlines
Mon, Feb 23 - Mon, Mar 2
DSM
Des Moines
BUF
Buffalo
$320 Roundtrip, just found
$320
Roundtrip
just found
Select Southwest Airlines flight, departing Mon, Feb 23 from Des Moines to Buffalo, returning Mon, Mar 2, priced at $320 just found

Find the cheapest month to fly from Des Moines (DSM) to Buffalo (BUF)

August is typically the cheapest month to fly

From $194 - $526 per traveler.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF) cost?
Lock in a cheap one-way flight from $148 or cheap return flight from $297 from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)?
October is the cheapest month to fly from DSM to BUF. Traveling outside of peak seasons is often the key to scoring lower fares.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)?
To find the cheapest airline that'll fly you from DSM to BUF, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to see the cheapest fares upfront.
How many flights per day from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)?
There aren't any daily direct flights departing from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from DSM to BUF?
Usually you'll find the largest variety of flight choices on a Friday. Tuesdays are often the quietest.* However, this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)?
Book a flight from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF) that takes off before 3 PM to reduce the risk of cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF) last-minute?
Waiting until just before your departure to book a ticket from DSM to BUF generally means paying more. While you might find some last-minute offers, they're not always guaranteed. Be flexible with your itinerary for the best chance of getting a bargain.
Is it cheaper to book a DSM to BUF flight and hotel package?
You'll generally save money by booking a DSM to BUF flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After choosing your ideal accommodations and flights, consider adding extras like car rentals, activities and tours.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Buffalo Niagara Intl. Airport (BUF)?
In most cases, you can reschedule or cancel your DSM to BUF flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline's fees and guidelines on flight changes, or if you'd like more details, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$296
Distance
768 mi

Book with confidence

Book with confidence

Des Moines to Buffalo Flights

The cheapest times to fly from Des Moines to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Buffalo are during the month of October. You can find some of the cheapest flights from Des Moines to Buffalo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Buffalo

Sunday is one of the best days to book for cheap flights from Des Moines to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $148 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Buffalo Flights

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*Available to One Key members.