$204 Cheap Flights from Des Moines (DSM) to Meridian (MEI)

View $204 flight on Sat, Nov 15, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Meridian, MS (MEI-Meridian Regional)

Cheap Flights from Des Moines to Meridian (DSM-MEI)

Prices were available within the past 7 days and start at $204 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI) cost?
Grab a cheap one-way flight from $204 or cheap return flight from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI)?
Planning your getaway for can help you save, as it's the cheapest month for flights between DSM and MEI. You'll typically find the lowest fares during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from DSM to MEI. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI)?
There are no daily nonstop flights departing from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds before you know it.
What day of the week has the most flights from DSM to MEI?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI)?
To reach Meridian Regional Airport (MEI) without delays, pick a flight that takes off from Des Moines Intl. Airport (DSM) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI) last-minute?
Last-minute fares from DSM to MEI are generally more expensive. For the best rates, start searching for flights well ahead of time. That said, if your travel plans are flexible, it's possible to find a cheap ticket just before your departure.
Is it cheaper to book a DSM to MEI flight and hotel package?
Opting for a DSM to MEI flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Select from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Meridian Regional Airport (MEI)?
If you reserved your DSM to MEI flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Meridian Regional
Distance
689 mi

Book with confidence

Des Moines to Meridian Flights

The cheapest times to fly from Des Moines to Meridian

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Meridian are during the month of . You can find some of the cheapest flights from Des Moines to Meridian with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Meridian

Sunday is one of the best days to book for cheap flights from Des Moines to Meridian: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Meridian

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Meridian in 2025. You can also book with separate airlines for your outbound and return journeys, from $204 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Meridian flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Meridian airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Meridian Flights

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*Available to One Key members.