$123 Cheap Flights from Myrtle Beach (MYR) to Chicago (MDW)

View $123 flight on Tue, Oct 28, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to Chicago Midway Airport (MDW)

Cheap Flights from Myrtle Beach to Chicago (MYR-MDW)

Prices were available within the past 7 days and start at $123 for one-way flights and $247 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Wed, Oct 22 - Wed, Nov 12
MYR
Myrtle Beach
MDW
Chicago
$247 Roundtrip, found 5 days ago
$247
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to Chicago, returning Wed, Nov 12, priced at $247 found 5 days ago
Southwest Airlines
Wed, Oct 22 - Wed, Nov 12
MYR
Myrtle Beach
MDW
Chicago
$257 Roundtrip, found 5 days ago
$257
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to Chicago, returning Wed, Nov 12, priced at $257 found 5 days ago
Southwest Airlines
Wed, Oct 22 - Wed, Nov 12
MYR
Myrtle Beach
MDW
Chicago
$262 Roundtrip, found 5 days ago
$262
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to Chicago, returning Wed, Nov 12, priced at $262 found 5 days ago
Southwest Airlines
Thu, Oct 23 - Tue, Oct 28
MYR
Myrtle Beach
MDW
Chicago
$266 Roundtrip, found 5 days ago
$266
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Thu, Oct 23 from Myrtle Beach to Chicago, returning Tue, Oct 28, priced at $266 found 5 days ago
Southwest Airlines
Wed, Oct 22 - Wed, Nov 12
MYR
Myrtle Beach
MDW
Chicago
$272 Roundtrip, found 5 days ago
$272
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Oct 22 from Myrtle Beach to Chicago, returning Wed, Nov 12, priced at $272 found 5 days ago
Southwest Airlines
Thu, Oct 23 - Tue, Oct 28
MYR
Myrtle Beach
MDW
Chicago
$276 Roundtrip, found 5 days ago
$276
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Thu, Oct 23 from Myrtle Beach to Chicago, returning Tue, Oct 28, priced at $276 found 5 days ago
Southwest Airlines
Thu, Oct 23 - Tue, Oct 28
MYR
Myrtle Beach
MDW
Chicago
$281 Roundtrip, found 5 days ago
$281
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Thu, Oct 23 from Myrtle Beach to Chicago, returning Tue, Oct 28, priced at $281 found 5 days ago
Southwest Airlines
Wed, Oct 29 - Sat, Nov 1
MYR
Myrtle Beach
MDW
Chicago
$284 Roundtrip, found 4 days ago
$284
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Wed, Oct 29 from Myrtle Beach to Chicago, returning Sat, Nov 1, priced at $284 found 4 days ago
Southwest Airlines
Thu, Oct 30 - Mon, Nov 3
MYR
Myrtle Beach
MDW
Chicago
$290 Roundtrip, found 12 hours ago
$290
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Thu, Oct 30 from Myrtle Beach to Chicago, returning Mon, Nov 3, priced at $290 found 12 hours ago
Delta
Wed, Oct 22 - Wed, Nov 12
MYR
Myrtle Beach
MDW
Chicago
$292 Roundtrip, found 5 days ago
$292
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Oct 22 from Myrtle Beach to Chicago, returning Wed, Nov 12, priced at $292 found 5 days ago

Find the cheapest month to fly from Myrtle Beach (MYR) to Chicago (MDW)

November is typically the cheapest month to fly

From $165 - $880 per traveler.

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O'Hare Intl. ORD. Cheapest option available. Average driving time to city center is 23 minutes. Flights from $176
ORD
O'Hare Intl.
Cheapest
Average driving time to city center23 min
Flights from $176

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW) cost?
Secure a cheap one-way flight from $123 or cheap return flight from $247 from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
October is the least expensive month to fly from MYR to MDW. Traveling outside of peak seasons is often the key to finding a great deal.
Which airlines fly direct from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
Take a nonstop flight with Southwest Airlines and journey straight from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW).
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest MYR to MDW flight.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
On average, Myrtle Beach Intl. Airport (MYR) has 6 direct flights to Midway Intl. Airport (MDW) per week. If you're looking for more options, use Expedia's filters to find flights with one or more stops. Fit in a quick visit to another city or just break up your journey.
What are the most popular departure times for flights from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
The 4 PM departures from MYR to MDW are the most sought after. These flights can come with a higher price due to their popularity. If you're looking to save, choose a less crowded time to fly.
What day of the week has the most flights from MYR to MDW?
If you depart on a Friday, you'll get the greatest range of choices for flights from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW).
What is the earliest flight from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
Catch the earliest flight at around 3:35PM UTC-5, heading out of Myrtle Beach Intl. Airport (MYR). You'll be flying for roughly 2h 15m, landing at Midway Intl. Airport (MDW) at approximately 4:50PM UTC-6.
How long does it take to fly from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
It takes approximately 2 hours and 15 minutes to cover the 740 mi from MYR to MDW.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
To land at Midway Intl. Airport (MDW) on time, book a flight that leaves from Myrtle Beach Intl. Airport (MYR) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Chicago from Myrtle Beach Intl. Airport (MYR)?
Midway Intl. Airport (MDW) is the only airport in Chicago with direct flights from Myrtle Beach Intl. Airport (MYR). Consider your options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW) last-minute?
Last-minute fares from MYR to MDW are generally more expensive. For the lowest rates, start searching for flights early. That said, if you're flexible with your travel dates, it's possible to land a cheap ticket right before your trip.
Is it cheaper to book a MYR to MDW flight and hotel package?
Opting for a MYR to MDW flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Choose from our impressive range of hotels and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Midway Intl. Airport (MDW)?
It's generally possible to cancel or reschedule your MYR to MDW flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find further details on our Customer Service portal.

Travel information

Travel information

Origin airport
Myrtle Beach Intl.
Destination airport
Midway Intl.
Airlines serving
Delta, Southwest Airlines
Roundtrip price
$247
Distance
737 mi
Average flight time
1 hour 55 mins

Book with confidence

Book with confidence

Myrtle Beach to Chicago Flights

The cheapest times to fly from Myrtle Beach to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Chicago are during the month of October. You can find some of the cheapest flights from Myrtle Beach to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to Chicago

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Chicago in 2025. You can also book with separate airlines for your outbound and return journeys, from $123 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Myrtle Beach to Chicago Flights

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*Available to One Key members.