$630 Cheap Flights from Panama City (PTY) to Manzanillo (ZLO)

View $630 flight on Wed, Feb 4, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Manzanillo, Colima (ZLO-Playa de Oro Intl.)

Cheap Flights from Panama City to Manzanillo (PTY-ZLO)

Prices were available within the past 7 days and start at $630 for one-way flights and $701 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Aeromexico
Sun, Dec 21 - Mon, Dec 29
PTY
Panama City
ZLO
Manzanillo
$701 Roundtrip, found 5 days ago
$701
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Sun, Dec 21 from Panama City to Manzanillo, returning Mon, Dec 29, priced at $701 found 5 days ago
Aeromexico
Mon, Dec 15 - Mon, Dec 29
PTY
Panama City
ZLO
Manzanillo
$722 Roundtrip, found 5 days ago
$722
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Mon, Dec 15 from Panama City to Manzanillo, returning Mon, Dec 29, priced at $722 found 5 days ago
Aeromexico
Sun, Dec 21 - Wed, Jan 7
PTY
Panama City
ZLO
Manzanillo
$740 Roundtrip, found 5 days ago
$740
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Sun, Dec 21 from Panama City to Manzanillo, returning Wed, Jan 7, priced at $740 found 5 days ago
Aeromexico
Sun, Dec 21 - Sun, Dec 28
PTY
Panama City
ZLO
Manzanillo
$742 Roundtrip, found 5 days ago
$742
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Sun, Dec 21 from Panama City to Manzanillo, returning Sun, Dec 28, priced at $742 found 5 days ago
Aeromexico
Mon, Dec 22 - Sun, Dec 28
PTY
Panama City
ZLO
Manzanillo
$744 Roundtrip, found 6 days ago
$744
Roundtrip
found 6 days ago
Select Aeromexico flight, departing Mon, Dec 22 from Panama City to Manzanillo, returning Sun, Dec 28, priced at $744 found 6 days ago
Aeromexico
Tue, Dec 16 - Wed, Jan 7
PTY
Panama City
ZLO
Manzanillo
$762 Roundtrip, found 5 days ago
$762
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Tue, Dec 16 from Panama City to Manzanillo, returning Wed, Jan 7, priced at $762 found 5 days ago
Aeromexico
Tue, Dec 16 - Sun, Dec 28
PTY
Panama City
ZLO
Manzanillo
$763 Roundtrip, found 5 days ago
$763
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Tue, Dec 16 from Panama City to Manzanillo, returning Sun, Dec 28, priced at $763 found 5 days ago
Aeromexico
Mon, Dec 15 - Sun, Dec 28
PTY
Panama City
ZLO
Manzanillo
$769 Roundtrip, found 5 days ago
$769
Roundtrip
found 5 days ago
Select Aeromexico flight, departing Mon, Dec 15 from Panama City to Manzanillo, returning Sun, Dec 28, priced at $769 found 5 days ago
American Airlines
Thu, Dec 18 - Wed, Dec 24
PTY
Panama City
ZLO
Manzanillo
$1,578 Roundtrip, found 6 days ago
$1,578
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Dec 18 from Panama City to Manzanillo, returning Wed, Dec 24, priced at $1,578 found 6 days ago
United
Thu, Dec 18 - Wed, Dec 24
PTY
Panama City
ZLO
Manzanillo
$2,957 Roundtrip, found 6 days ago
$2,957
Roundtrip
found 6 days ago
Select United flight, departing Thu, Dec 18 from Panama City to Manzanillo, returning Wed, Dec 24, priced at $2,957 found 6 days ago

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Flights from Panama City (PTY) to Manzanillo (ZLO)
Origin airport
Tocumen Intl.
Destination airport
Playa de Oro Intl.
Roundtrip price
$700
Distance
1821 mi

Panama City to Manzanillo Flights

The cheapest times to fly from Panama City to Manzanillo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Manzanillo are during the month of December. You can find some of the cheapest flights from Panama City to Manzanillo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Manzanillo

Sunday is one of the best days to book for cheap flights from Panama City to Manzanillo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Manzanillo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Manzanillo in 2025. You can also book with separate airlines for your outbound and return journeys, from $630 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Manzanillo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Manzanillo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO) cost?
Secure a cheap one-way flight from $630 or cheap return flight from $701 from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO)?
The cheapest month to fly from PTY to ZLO is December, when there's less demand. Off-peak season is generally when you'll find lower airfares between these airports.
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest PTY to ZLO flight.
How many flights per day from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO)?
There are no daily nonstop flights available from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from PTY to ZLO?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a range of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO)?
To land at Playa de Oro Intl. Airport (ZLO) on schedule, choose a flight that leaves Tocumen Intl. Airport (PTY) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO) last-minute?
Holding off until just before your departure to book a flight from PTY to ZLO generally means paying more. While it's possible to find some last-minute discounts, there's no guarantee. Be flexible with your travel plans to maximize your chances of landing a bargain.
Is it cheaper to book a PTY to ZLO flight and hotel package?
You'll generally save money by booking a PTY to ZLO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one convenient place. Once you've selected your preferred accommodations and flights, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Playa de Oro Intl. Airport (ZLO)?
If you booked your PTY to ZLO flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.