$149 Cheap Flights from Knoxville (TYS) to Harrisburg (MDT)

View $149 flight on Wed, Dec 31, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)

Cheap Flights from Knoxville to Harrisburg (TYS-MDT)

Prices were available within the past 7 days and start at $149 for one-way flights and $229 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Nov 20 - Tue, Dec 2
TYS
Knoxville
MDT
Harrisburg
$229 Roundtrip, found 1 hour ago
$229
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, Nov 20 from Knoxville to Harrisburg, returning Tue, Dec 2, priced at $229 found 1 hour ago
United
Thu, Nov 20 - Sun, Nov 23
TYS
Knoxville
MDT
Harrisburg
$229 Roundtrip, found 18 hours ago
$229
Roundtrip
found 18 hours ago
Select United flight, departing Thu, Nov 20 from Knoxville to Harrisburg, returning Sun, Nov 23, priced at $229 found 18 hours ago
United
Sat, Jan 24 - Sat, Jan 31
TYS
Knoxville
MDT
Harrisburg
$234 Roundtrip, found 3 days ago
$234
Roundtrip
found 3 days ago
Select United flight, departing Sat, Jan 24 from Knoxville to Harrisburg, returning Sat, Jan 31, priced at $234 found 3 days ago
United
Fri, Nov 14 - Sun, Nov 16
TYS
Knoxville
MDT
Harrisburg
$239 Roundtrip, found 2 days ago
$239
Roundtrip
found 2 days ago
Select United flight, departing Fri, Nov 14 from Knoxville to Harrisburg, returning Sun, Nov 16, priced at $239 found 2 days ago
United
Thu, Nov 20 - Sun, Nov 23
TYS
Knoxville
MDT
Harrisburg
$241 Roundtrip, found 18 hours ago
$241
Roundtrip
found 18 hours ago
Select United flight, departing Thu, Nov 20 from Knoxville to Harrisburg, returning Sun, Nov 23, priced at $241 found 18 hours ago
Delta
Wed, Nov 12 - Tue, Dec 2
TYS
Knoxville
MDT
Harrisburg
$244 Roundtrip, found 1 day ago
$244
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Nov 12 from Knoxville to Harrisburg, returning Tue, Dec 2, priced at $244 found 1 day ago
United
Wed, Nov 12 - Sat, Nov 15
TYS
Knoxville
MDT
Harrisburg
$244 Roundtrip, found 3 days ago
$244
Roundtrip
found 3 days ago
Select United flight, departing Wed, Nov 12 from Knoxville to Harrisburg, returning Sat, Nov 15, priced at $244 found 3 days ago
United
Wed, Jan 28 - Mon, Feb 2
TYS
Knoxville
MDT
Harrisburg
$246 Roundtrip, found 2 days ago
$246
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jan 28 from Knoxville to Harrisburg, returning Mon, Feb 2, priced at $246 found 2 days ago
Delta
Tue, Jan 13 - Mon, Jan 26
TYS
Knoxville
MDT
Harrisburg
$263 Roundtrip, found 9 hours ago
$263
Roundtrip
found 9 hours ago
Select Delta flight, departing Tue, Jan 13 from Knoxville to Harrisburg, returning Mon, Jan 26, priced at $263 found 9 hours ago
American Airlines
Sat, Nov 8 - Fri, Nov 28
TYS
Knoxville
MDT
Harrisburg
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Nov 8 from Knoxville to Harrisburg, returning Fri, Nov 28, priced at $264 found 1 day ago

Find the cheapest month to fly from Knoxville (TYS) to Harrisburg (MDT)

May is typically the cheapest month to fly

From $213 - $556 per traveler.

Alternative airports near Harrisburg

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lancaster, PA LNS. Average driving time to city center is 48 minutes. Flights from $351
LNS
Lancaster, PA
Average driving time to city center48 min
Flights from $351

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT) cost?
Get a cheap one-way flight from $149 or cheap return flight from $229 from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)?
Flying in November can help you save, as it's the cheapest month for flights between TYS and MDT. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)?
To find the cheapest airline that'll fly you from TYS to MDT, use Expedia's filter tool. Tailor your search based on what's important to you, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)?
Nonstop flights from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filters. Enter your dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from TYS to MDT?
Typically you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)?
To avoid potential delays on the McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT) route, aim to travel before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT) last-minute?
Waiting until right before your break to book a flight from TYS to MDT often results in higher prices. While it's possible to find some last-minute deals, they aren't always guaranteed. Be flexible with your travel plans to boost your chances of landing a bargain.
Is it cheaper to book a TYS to MDT flight and hotel package?
You'll generally save money by booking a TYS to MDT flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one convenient place. After choosing your ideal accommodations and flights, consider adding extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Harrisburg Intl. Airport (MDT)?
In most cases, you can reschedule or cancel your TYS to MDT flight. However, there may be additional fees, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's policies and fees on flight changes, or if you need further information, go to our Customer Service portal.

Travel information

Origin airport
McGhee Tyson
Destination airport
Harrisburg Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$228
Distance
496 mi

Book with confidence

Knoxville to Harrisburg Flights

The cheapest times to fly from Knoxville to Harrisburg

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Harrisburg are during the month of November. You can find some of the cheapest flights from Knoxville to Harrisburg with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Knoxville to Harrisburg

Sunday is one of the best days to book for cheap flights from Knoxville to Harrisburg: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Knoxville to Harrisburg

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Harrisburg in 2025. You can also book with separate airlines for your outbound and return journeys, from $149 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Harrisburg flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Harrisburg airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Knoxville to Harrisburg Flights

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*Available to One Key members.