$240 Cheap Flights from Quito (UIO) to Santiago (SCL)

View $240 flight on Wed, Feb 4, 2026Opens in a new window

Popular airlines from Mariscal Sucre Intl. Airport (UIO) to Santiago Intl. Airport (SCL)

Cheap Flights from Quito to Santiago (UIO-SCL)

Prices were available within the past 7 days and start at $240 for one-way flights and $361 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Wed, Apr 22 - Sun, May 3
UIO
Quito
SCL
Santiago
$361 Roundtrip, found 15 hours ago
$361
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Wed, Apr 22 from Quito to Santiago, returning Sun, May 3, priced at $361 found 15 hours ago
Jetsmart SPA
Wed, Apr 22 - Fri, Apr 24
UIO
Quito
SCL
Santiago
$364 Roundtrip, found 15 hours ago
$364
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Wed, Apr 22 from Quito to Santiago, returning Fri, Apr 24, priced at $364 found 15 hours ago
Jetsmart SPA
Wed, Apr 22 - Sun, May 10
UIO
Quito
SCL
Santiago
$370 Roundtrip, found 15 hours ago
$370
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Wed, Apr 22 from Quito to Santiago, returning Sun, May 10, priced at $370 found 15 hours ago
Jetsmart SPA
Sun, Apr 19 - Sun, May 10
UIO
Quito
SCL
Santiago
$376 Roundtrip, found 15 hours ago
$376
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Sun, Apr 19 from Quito to Santiago, returning Sun, May 10, priced at $376 found 15 hours ago
Jetsmart SPA
Wed, Apr 22 - Sun, Apr 26
UIO
Quito
SCL
Santiago
$377 Roundtrip, found 15 hours ago
$377
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Wed, Apr 22 from Quito to Santiago, returning Sun, Apr 26, priced at $377 found 15 hours ago
Jetsmart SPA
Sun, Apr 19 - Wed, Apr 22
UIO
Quito
SCL
Santiago
$379 Roundtrip, found 15 hours ago
$379
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Sun, Apr 19 from Quito to Santiago, returning Wed, Apr 22, priced at $379 found 15 hours ago
Jetsmart SPA
Sun, Apr 19 - Fri, May 8
UIO
Quito
SCL
Santiago
$382 Roundtrip, found 15 hours ago
$382
Roundtrip
found 15 hours ago
Select Jetsmart SPA flight, departing Sun, Apr 19 from Quito to Santiago, returning Fri, May 8, priced at $382 found 15 hours ago
LATAM Airlines Group
Wed, Mar 18 - Wed, Mar 25
UIO
Quito
SCL
Santiago
$416 Roundtrip, found 4 days ago
$416
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Wed, Mar 18 from Quito to Santiago, returning Wed, Mar 25, priced at $416 found 4 days ago
Copa
Thu, Mar 12 - Wed, Mar 18
UIO
Quito
SCL
Santiago
$487 Roundtrip, found 4 hours ago
$487
Roundtrip
found 4 hours ago
Select Copa flight, departing Thu, Mar 12 from Quito to Santiago, returning Wed, Mar 18, priced at $487 found 4 hours ago
avianca
Tue, Nov 18 - Thu, Nov 20
UIO
Quito
SCL
Santiago
$528 Roundtrip, just found
$528
Roundtrip
just found
Select avianca flight, departing Tue, Nov 18 from Quito to Santiago, returning Thu, Nov 20, priced at $528 just found

Find the cheapest month to fly from Quito (UIO) to Santiago (SCL)

March is typically the cheapest month to fly

From $366 - $553 per traveler.

Alternative airports near Santiago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Arturo Merino Benitez SCL. Cheapest and Closest option available. Average driving time to city center is 17 minutes. Flights from $569
SCL
Arturo Merino Benitez
CheapestClosest
Average driving time to city center17 min
Flights from $569

Frequently asked questions

How much does a flight from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL) cost?
Get a cheap one-way flight from $240 or cheap return flight from $361 from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL)?
The cheapest month to fly from UIO to SCL is April, when there's less demand. Off-peak months are usually when better flight deals are available between these airports.
What is the cheapest airline that flies from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL)?
Use the filter tool on Expedia to compare different airlines and find the most affordable carrier that'll take you from UIO to SCL. Then, sort your results by "Price (lowest to highest)" to snap up a good deal.
How many flights per day from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL)?
Direct flights from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL) aren't available daily, so you'll have to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from UIO to SCL?
You'll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL)?
To avoid potential delays on the Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL) route, fly before 3 PM. Later flights are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL) last-minute?
Holding off until just before your departure to book a flight from UIO to SCL generally means paying more. While you might find some last-minute discounts, there's no guarantee. Keep your travel plans flexible to maximize your chances of landing a bargain.
Is it cheaper to book an UIO to SCL flight and hotel package?
Opting for an UIO to SCL flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Select from our wide range of accommodations and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Mariscal Sucre Intl. Airport (UIO) to Arturo Merino Benitez Airport (SCL)?
If you booked your UIO to SCL flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

Travel information

Origin airport
Mariscal Sucre Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Copa, Jetsmart SPA, LATAM Airlines Group, avianca
Roundtrip price
$361
Distance
2350 mi

Book with confidence

Quito to Santiago Flights

The cheapest times to fly from Quito to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Quito to Santiago are during the month of April. You can find some of the cheapest flights from Quito to Santiago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Quito to Santiago

Sunday is one of the best days to book for cheap flights from Quito to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Quito to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Quito to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $240 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Quito to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Quito to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Quito to Santiago Flights

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*Available to One Key members.