$139 Cheap American Airlines flights Des Moines (DSM) to Fort Myers (RSW)

Finding cheap one-way American Airlines flights from DSM to RSW from $139 on Expedia is a breeze — just filter by “Price (lowest to highest).” Alternatively, check out our affordable round-trip fares from $277 for your next break.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to Fort Myers are usually cheaper in the low-season months of August and September. Whether you need a one-way or round-trip ticket, you could score a better deal then.

Look for affordable American Airlines flights from Des Moines Intl. Airport (DSM) to Southwest Florida Intl. Airport (RSW) one to three months prior to your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. Regardless of fare class and journey, the ideal day to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct trip from DSM to RSW with American Airlines or another airline, check the “Nonstop” box when looking for flights.

To find the earliest departures from DSM to RSW with American Airlines, filter your search by “Morning” and “Early Morning.” Booking an early flight usually means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Des Moines Intl. Airport (DSM) to Fort Myers land at Southwest Florida Intl. Airport (RSW). This is the main entry point here.

Depending on the ticket type you purchased, a fee may apply if you change or cancel your booking more than 24 hours after it has been confirmed. To find flexible plane tickets, select our “Changes included” or “No cancel fee” filter while looking for flights. For additional information on modifying or canceling your reservation, go to “Trips,” select your flight and tick “Manage Booking.”