$143 Cheap American Airlines flights Des Moines (DSM) to Tampa (TPA)

Apply the “Price (lowest to highest)” filter on Expedia to look for cheap American Airlines round-trip flights from $285 from DSM to TPA. Affordable one-way options from $143 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

September is one of the least expensive months to travel to Tampa with American Airlines. You could also find great deals on one-way and round-trip tickets in November.

Begin your search one to three months ahead of your departure date to score cheaper fares on American Airlines flights from Des Moines Intl. Airport (DSM) to Tampa Intl. Airport (TPA). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get your timing right, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct trip from DSM to TPA with American Airlines or any other airlines, select the “Nonstop” filter when browsing for tickets.

To find the earliest departure from DSM to TPA with American Airlines, filter your search by “Early Morning” and “Morning.” Booking an early flight generally means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Tampa Intl. Airport (TPA) is the primary Tampa hub for American Airlines flights from Des Moines Intl. Airport (DSM).

Changes are often free within 24 hours of making your booking, but your airline may add a charge after that. For more details about modifying your reservation, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to update your itinerary without additional costs, check the “Changes included” or “No cancel fee” filter when planning your next escape.