$110 Cheap American Airlines flights Syracuse (SYR) to Jacksonville (JAX)

Landing cheap one-way American Airlines flights from SYR to JAX from $110 on Expedia is a cinch — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly return fares from $201 for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Begin your search one to three months before your departure to get cheaper fares on American Airlines flights from Hancock Intl. Airport (SYR) to Jacksonville Intl. Airport (JAX). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also reduce costs by buying your fare on a Sunday, as it's 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic journeys.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

To find the earliest departure from SYR to JAX with American Airlines, filter your results by "Early Morning" and "Morning." Booking an early flight usually means you'll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.