$268 Cheap American Airlines flights Key West (EYW) to St. Thomas (STT)

Finding cheap one-way American Airlines flights from EYW to STT from $268 on Expedia couldn't be easier — just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly return fares from $479 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Check for American Airlines flights from EYW to STT about one month before you want to leave. The most affordable time to reserve an international flight is usually 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. Regardless of fare class and itinerary, the best day of the week to book international airfare is usually Sunday. Friday is often the most expensive. Passengers booking on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to see the earliest departures from EYW to STT. Setting off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.