Cheap American Airlines flights Islip (ISP) to Charleston (CHS)

Scoring cheap one-way American Airlines flights from ISP to CHS on Expedia couldn’t be easier — just filter by “Price (lowest to highest).” Alternatively, check out our affordable round-trip fares for your next getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for one-way or round-trip flights to Charleston in January or December. You could find lower fares with American Airlines during these off-peak months.

For cheap American Airlines fares from MacArthur Airport (ISP) to Charleston Intl. Airport (CHS), start searching one to three months before your intended departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also affect how much you pay. Sunday is generally the cheapest, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your journey on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct trip from ISP to CHS with American Airlines or another airline, select the “Nonstop” filter when looking for flights.

Filter your results by “Early Morning” and “Morning” to browse the earliest flights from ISP to CHS. Taking off early means you’re less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from MacArthur Airport (ISP) to Charleston arrive at Charleston Intl. Airport (CHS). This is the main gateway here.

Changes are often free within 24 hours of booking, but your airline may charge you after that time. For more details about modifying your flights, head to your “Trips,” select your flight and click on “Manage Booking.” If you’d like the freedom to change your plans without additional costs, check the “No cancel fee” or “Changes included” filter when organizing your next getaway.