$274 Cheap American Airlines flights Knoxville (TYS) to St. Thomas (STT)

Scoring cheap one-way American Airlines flights from TYS to STT from $274 on Expedia couldn't be easier --- just filter by "Price (lowest to highest)." Alternatively, check out our budget-friendly return fares from $479 for your next exciting getaway.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Check for American Airlines flights from TYS to STT about one month before you want to leave. The most affordable time to book an international flight is usually 18 to 29 days ahead of your travel date when you can save 17% versus booking four to five months in advance. No matter your itinerary or ticket type, the best day of the week to book international airfare is usually Sunday. Friday is often the most expensive. Travelers booking on a Sunday can save 17% on average compared to those who book on a Friday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Sort your results by "Morning" and "Early Morning" to find the earliest flights from TYS to STT. Heading off early means flight cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.