$144 Cheap American Airlines flights Philadelphia (PHL) to Buffalo (BUF)

Set the "Price (lowest to highest)" filter on Expedia to look for cheap American Airlines round-trip flights from $308 from PHL to BUF. Affordable one-way fares from $144 are available too.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To find cheap American Airlines fares from Philadelphia Intl. Airport (PHL) to Buffalo Niagara Intl. Airport (BUF), start searching one to three months before your intended departure. Securing domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by choosing to book on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

The first flight from PHL to BUF with American Airlines departs at 10:45AM UTC-5. You'll land at 12:14PM UTC-5. The final American Airlines flight of the day takes off at 9:10PM UTC-5 and arrives at 10:35PM UTC-5. With around 20% fewer cancellations for early and mid-morning flights, heading out early is generally the best option.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.